Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study

Byoung-Jin Park, Yong-Jae Lee, Hye-Ree Lee, Dong-Hyuk Jung, Ha-Young Na, Hong-Bae Kim, Jae-Yong Shim, Byoung-Jin Park, Yong-Jae Lee, Hye-Ree Lee, Dong-Hyuk Jung, Ha-Young Na, Hong-Bae Kim, Jae-Yong Shim

Abstract

Background: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome.

Methods: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits.

Results: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV.

Conclusion: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population.

Trial registration: ClinicalTrials.gov Identifier: NCT00976274.

Keywords: Metabolic Syndrome; Panax ginseng; Randomized Controlled Trial.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Flowchart of the study design and subject participation. KRG: Korean red ginseng, baPWV: brachial-ankle pulse wave velocity.

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