Precision Medicine: From Science To Value

Abstract

Precision medicine is making an impact on patients, health care delivery systems, and research participants in ways that were only imagined fifteen years ago when the human genome was first sequenced. Discovery of disease-causing and drug-response genetic variants has accelerated, while adoption into clinical medicine has lagged. We define precision medicine and the stakeholder community required to enable its integration into research and health care. We explore the intersection of data science, analytics, and precision medicine in the formation of health systems that carry out research in the context of clinical care and that optimize the tools and information used to deliver improved patient outcomes. We provide examples of real-world impact and conclude with a policy and economic agenda necessary for the adoption of this new paradigm of health care both in the United States and globally.

Keywords: Digital Health; Genomic Medicine; Genomics; Medicine/Clinical Issues; Precision Medicine.

Figures

Exhibit 1

The Precision Medicine Ecosystem Source: Adapted from reference

Exhibit 2

The Genomics Enabled Learning Health System Source: Adapted from reference

Exhibit 3

Timeline Of Precision Medicine Applications In Across The Lifespan Source: From reference , with permission