Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association

Glenn N Levine, Richard A Lange, C Noel Bairey-Merz, Richard J Davidson, Kenneth Jamerson, Puja K Mehta, Erin D Michos, Keith Norris, Indranill Basu Ray, Karen L Saban, Tina Shah, Richard Stein, Sidney C Smith Jr, American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension, Glenn N Levine, Richard A Lange, C Noel Bairey-Merz, Richard J Davidson, Kenneth Jamerson, Puja K Mehta, Erin D Michos, Keith Norris, Indranill Basu Ray, Karen L Saban, Tina Shah, Richard Stein, Sidney C Smith Jr, American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension

Abstract

Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have reported on the benefits of meditation. Meditation instruction and practice is widely accessible and inexpensive and may thus be a potential attractive cost-effective adjunct to more traditional medical therapies. Accordingly, this American Heart Association scientific statement systematically reviewed the data on the potential benefits of meditation on cardiovascular risk. Neurophysiological and neuroanatomical studies demonstrate that meditation can have long-standing effects on the brain, which provide some biological plausibility for beneficial consequences on the physiological basal state and on cardiovascular risk. Studies of the effects of meditation on cardiovascular risk have included those investigating physiological response to stress, smoking cessation, blood pressure reduction, insulin resistance and metabolic syndrome, endothelial function, inducible myocardial ischemia, and primary and secondary prevention of cardiovascular disease. Overall, studies of meditation suggest a possible benefit on cardiovascular risk, although the overall quality and, in some cases, quantity of study data are modest. Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline-directed cardiovascular risk reduction by those interested in this lifestyle modification, with the understanding that the benefits of such intervention remain to be better established. Further research on meditation and cardiovascular risk is warranted. Such studies, to the degree possible, should utilize randomized study design, be adequately powered to meet the primary study outcome, strive to achieve low drop-out rates, include long-term follow-up, and be performed by those without inherent bias in outcome.

Keywords: AHA Scientific Statements; cardiovascular disease; cardiovascular risk; meditation; primary prevention; secondary prevention.

© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

References

    1. Centers for Disease Control and Prevention . Heart disease facts. 2016. Available at: . Accessed September 23, 2016.
    1. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, Isasi CR, Jimenez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Mackey RH, Matsushita K, Mozaffarian D, Mussolino ME, Nasir K, Neumar RW, Palaniappan L, Pandey DK, Thiagarajan RR, Reeves MJ, Ritchey M, Rodriguez CJ, Roth GA, Rosamond WD, Sasson C, Towfighi A, Tsao CW, Turner MB, Virani SS, Voeks JH, Willey JZ, Wilkins JT, Wu JHY, Alger HM, Wong SS, Muntner P; on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee . Heart disease and stroke statistics—2017 update: a report from the American Heart Association [published correction appears in Circulation 2017;135:e646]. Circulation. 2017;135:e146–e603. DOI: 10.1161/CIR.0000000000000485.
    1. Writing Committee , Smith SC Jr, Collins A, Ferrari R, Holmes DR Jr, Logstrup S, McGhie DV, Ralston J, Sacco RL, Stam H, Taubert K, Wood DA, Zoghbi WA. Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke). Glob Heart. 2012;7:297–305.
    1. World Health Organization . Global health observatory data repository. Cardiovascular diseases, deaths per 100,000. Data by country. 2016. Available at: . Accessed September 23, 2016.
    1. World Heart Federation . Deaths due to cardiovascular disease. 2016. Available at: . Accessed September 23, 2016.
    1. Fryer CD, Chen TC, Li X. Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999–2010. 2012. NCHS Data Brief. No 102. Available at: . Accessed September 23, 2016.
    1. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention . National Diabetes Statistics Report, 201. 2014. Available at: . Accessed September 23, 2016.
    1. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, Finkelstein EA, Hong Y, Johnston SC, Khera A, Lloyd‐Jones DM, Nelson SA, Nichol G, Orenstein D, Wilson PW, Woo YJ; on behalf of the American Heart Association Advocacy Coordinating Committee; Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Arteriosclerosis; Thrombosis and Vascular Biology; Council on Cardiopulmonary; Critical Care; Perioperative and Resuscitation; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research . Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933–944.
    1. Use of complementary health approaches in the U.S. National Health Interview Survey. National Center for Complementary and Integrative Health. National Institute of Medicine; 2012. Available at: . Accessed September 23, 2016.
    1. Prasad K, Sharma V, Lackore K, Jenkins SM, Prasad A, Sood A. Use of complementary therapies in cardiovascular disease. Am J Cardiol. 2013;111:339–345.
    1. Saydah SH, Eberhardt MS. Use of complementary and alternative medicine among adults with chronic diseases: United States 2002. J Altern Complement Med. 2006;12:805–812.
    1. Leung YW, Tamim H, Stewart DE, Arthur HM, Grace SL. The prevalence and correlates of mind‐body therapy practices in patients with acute coronary syndrome. Complement Ther Med. 2008;16:254–261.
    1. Yeh GY, Davis RB, Phillips RS. Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol. 2006;98:673–680.
    1. Thompson PD, Buchner D, Piña IL, Balady GJ, Williams MA, Marcus BH, Berra K, Blair SN, Costa F, Franklin B, Fletcher GF, Gordon NF, Pate RR, Rodriguez BL, Yancey AK, Wenger NK. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107:3109–3116.
    1. Shiroma EJ, Lee IM. Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity. Circulation. 2010;122:743–752.
    1. Gawler I, Bedson P. Meditation. An In‐Depth Guide. New York, NY: Jeremy P. Tarcher/Penguin; 2011.
    1. Meditation. National Center for Complementary and Integrative Health. National Institute of Health; 2016. Available at: . Accessed February 26, 2017.
    1. Ricard M, Lutz A, Davidson RJ. Mind of the meditator. Sci Am. 2014;311:38–45.
    1. Goyal M, Singh S, Sibinga EM, Gould NF, Rowland‐Seymour A, Sharma R, Berger Z, Sleicher D, Maron DD, Shihab HM, Ranasinghe PD, Linn S, Saha S, Bass EB, Haythornthwaite JA. Meditation programs for psychological stress and well‐being: a systematic review and meta‐analysis. JAMA Intern Med. 2014;174:357–368.
    1. Pantuso T. Meditation Types and Clinical Use. Chicago, IL: AHC Media; 2015.
    1. Rakel D. Integrative Medicine. 3rd ed Philadelphia, PA: Saunders; 2012.
    1. Eisler M. 11 meditation styles and techniques explained. 2015. Available at: . Accessed February 26, 2017.
    1. Wallace B. The Buddhist tradition of Samatha. J Conscious Stud. 1999;6:175–187.
    1. Types of meditation: extensive list of techniques. 2016. Available at: . Accessed February 26, 2017.
    1. Maharishi Foundation USA . What is TM? 2017. Available at: . Accessed February 26, 2017.
    1. ZEN‐ . Zen Buddhism. 2017. Available at: . Accessed February 26, 2017.
    1. Mitchell M. Dr. Herbert Benson's Relaxation Response. 2017. Available at: . Accessed February 26, 2017.
    1. Nazari J, Hebert M. Raja Yogis. 2017. Available at: . Accessed February 26, 2017.
    1. Lutz A, Slagter HA, Dunne JD, Davidson RJ. Attention regulation and monitoring in meditation. Trends Cogn Sci. 2008;12:163–169.
    1. Davidson RJ, Lutz A. Buddha's brain: neuroplasticity and meditation. IEEE Signal Process Mag. 2008;25:176–174.
    1. Brewer JA, Worhunsky PD, Gray JR, Tang YY, Weber J, Kober H. Meditation experience is associated with differences in default mode network activity and connectivity. Proc Natl Acad Sci USA. 2011;108:20254–20259.
    1. Weng HY, Fox AS, Shackman AJ, Stodola DE, Caldwell JZ, Olson MC, Rogers GM, Davidson RJ. Compassion training alters altruism and neural responses to suffering. Psychol Sci. 2013;24:1171–1180.
    1. Klimecki OM, Leiberg S, Ricard M, Singer T. Differential pattern of functional brain plasticity after compassion and empathy training. Soc Cogn Affect Neurosci. 2014;9:873–879.
    1. Davidson RJ, Kabat‐Zinn J, Schumacher J, Rosenkranz M, Muller D, Santorelli SF, Urbanowski F, Harrington A, Bonus K, Sheridan JF. Alterations in brain and immune function produced by mindfulness meditation. Psychosom Med. 2003;65:564–570.
    1. Lutz A, Greischar LL, Rawlings NB, Ricard M, Davidson RJ. Long‐term meditators self‐induce high‐amplitude gamma synchrony during mental practice. Proc Natl Acad Sci USA. 2004;101:16369–16373.
    1. Vestergaard‐Poulsen P, van Beek M, Skewes J, Bjarkam CR, Stubberup M, Bertelsen J, Roepstorff A. Long‐term meditation is associated with increased gray matter density in the brain stem. Neuroreport. 2009;20:170–174.
    1. Tang YY, Holzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16:213–225.
    1. Fox KC, Nijeboer S, Dixon ML, Floman JL, Ellamil M, Rumak SP, Sedlmeier P, Christoff K. Is meditation associated with altered brain structure? A systematic review and meta‐analysis of morphometric neuroimaging in meditation practitioners. Neurosci Biobehav Rev. 2014;43:48–73.
    1. Carlson LE, Doll R, Stephen J, Faris P, Tamagawa R, Drysdale E, Speca M. Randomized controlled trial of mindfulness‐based cancer recovery versus supportive expressive group therapy for distressed survivors of breast cancer. J Clin Oncol. 2013;31:3119–3126.
    1. Tang YY, Ma Y, Wang J, Fan Y, Feng S, Lu Q, Yu Q, Sui D, Rothbart MK, Fan M, Posner MI. Short‐term meditation training improves attention and self‐regulation. Proc Natl Acad Sci USA. 2007;104:17152–17156.
    1. Black DS, O'Reilly GA, Olmstead R, Breen EC, Irwin MR. Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015;175:494–501.
    1. Klatt MD, Buckworth J, Malarkey WB. Effects of low‐dose mindfulness‐based stress reduction (MBSR‐ld) on working adults. Health Educ Behav. 2009;36:601–614.
    1. Pace TW, Negi LT, Adame DD, Cole SP, Sivilli TI, Brown TD, Issa MJ, Raison CL. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology. 2009;34:87–98.
    1. Cash E, Salmon P, Weissbecker I, Rebholz WN, Bayley‐Veloso R, Zimmaro LA, Floyd A, Dedert E, Sephton SE. Mindfulness meditation alleviates fibromyalgia symptoms in women: results of a randomized clinical trial. Ann Behav Med. 2015;49:319–330.
    1. Speca M, Carlson LE, Goodey E, Angen M. A randomized, wait‐list controlled clinical trial: the effect of a mindfulness meditation‐based stress reduction program on mood and symptoms of stress in cancer outpatients. Psychosom Med. 2000;62:613–622.
    1. Goyal M, Singh SS, Sibinga EM, Gould NF, Rowland‐Seymour A, Sharma R, Berger Z, Sleicher D, Maron DD, Shihab HM, Ranasinghe PD, Linn S, Saha S, Bass EB, Haythornthwaite JA. Meditation programs for psychological stress and well‐being. Comparitive Effectiveness Review No. 124. Rockville, MD: Agency for Healthcare Research and Quality; 2014.
    1. Momeni J, Omidi A, Raygan F, Akbari H. The effects of mindfulness‐based stress reduction on cardiac patients' blood pressure, perceived stress, and anger: a single‐blind randomized controlled trial. J Am Soc Hypertens. 2016;10:763–771.
    1. de Fatima Rosas MM, Kozasa EH, Miranda RD, Monezi Andrade AL, Perrotti TC, Leite JR. Decrease in blood pressure and improved psychological aspects through meditation training in hypertensive older adults: a randomized control study. Geriatr Gerontol Int. 2015;15:1158–1164.
    1. Lipschitz DL, Kuhn R, Kinney AY, Donaldson GW, Nakamura Y. Reduction in salivary alpha‐amylase levels following a mind‐body intervention in cancer survivors—an exploratory study. Psychoneuroendocrinology. 2013;38:1521–1531.
    1. Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH, Lutz A. A comparison of mindfulness‐based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun. 2013;27:174–184.
    1. Epel ES, Puterman E, Lin J, Blackburn EH, Lum PY, Beckmann ND, Zhu J, Lee E, Gilbert A, Rissman RA, Tanzi RE, Schadt EE. Meditation and vacation effects have an impact on disease‐associated molecular phenotypes. Transl Psychiatry. 2016;6:e880.
    1. Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011;36:664–681.
    1. Carlson LE, Speca M, Faris P, Patel KD. One year pre‐post intervention follow‐up of psychological, immune, endocrine and blood pressure outcomes of mindfulness‐based stress reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun. 2007;21:1038–1049.
    1. Malarkey WB, Jarjoura D, Klatt M. Workplace based mindfulness practice and inflammation: a randomized trial. Brain Behav Immun. 2013;27:145–154.
    1. Witek‐Janusek L, Albuquerque K, Chroniak KR, Chroniak C, Durazo‐Arvizu R, Mathews HL. Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain Behav Immun. 2008;22:969–981.
    1. Jensen CG, Vangkilde S, Frokjaer V, Hasselbalch SG. Mindfulness training affects attention—or is it attentional effort? J Exp Psychol Gen. 2012;141:106–123.
    1. Creswell JD, Irwin MR, Burklund LJ, Lieberman MD, Arevalo JM, Ma J, Breen EC, Cole SW. Mindfulness‐based stress reduction training reduces loneliness and pro‐inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012;26:1095–1101.
    1. Qu S, Olafsrud SM, Meza‐Zepeda LA, Saatcioglu F. Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program. PLoS One. 2013;8:e61910.
    1. Bower JE, Irwin MR. Mind‐body therapies and control of inflammatory biology: a descriptive review. Brain Behav Immun. 2016;51:1–11.
    1. Manikonda JP, Störk S, Tögel S, Lobmüller A, Grünberg I, Bedel S, Schardt F, Angermann CE, Jahns R, Voelker W. Contemplative meditation reduces ambulatory blood pressure and stress‐induced hypertension: a randomized pilot trial. J Hum Hypertens. 2008;22:138–140.
    1. Hughes JW, Fresco DM, Myerscough R, van Dulmen MH, Carlson LE, Josephson R. Randomized controlled trial of mindfulness‐based stress reduction for prehypertension. Psychosom Med. 2013;75:721–728.
    1. Gregoski MJ, Barnes VA, Tingen MS, Harshfield GA, Treiber FA. Breathing awareness meditation and LifeSkills Training programs influence upon ambulatory blood pressure and sodium excretion among African American adolescents. J Adolesc Health. 2011;48:59–64.
    1. Blom K, Baker B, How M, Dai M, Irvine J, Abbey S, Abramson BL, Myers MG, Kiss A, Perkins NJ, Tobe SW. Hypertension analysis of stress reduction using mindfulness meditation and yoga: results from the HARMONY randomized controlled trial. Am J Hypertens. 2014;27:122–129.
    1. Palta P, Page G, Piferi RL, Gill JM, Hayat MJ, Connolly AB, Szanton SL. Evaluation of a mindfulness‐based intervention program to decrease blood pressure in low‐income African‐American older adults. J Urban Health. 2012;89:308–316.
    1. Chung SC, Brooks MM, Rai M, Balk JL, Rai S. Effect of Sahaja yoga meditation on quality of life, anxiety, and blood pressure control. J Altern Complement Med. 2012;18:589–596.
    1. Yeh GY, Wang C, Wayne PM, Phillips RS. The effect of tai chi exercise on blood pressure: a systematic review. Prev Cardiol. 2008;11:82–89.
    1. Xiong X, Wang P, Li X, Zhang Y. Qigong for hypertension: a systematic review. Medicine (Baltimore). 2015;94:e352.
    1. Dhameja K, Singh S, Mustafa MD, Singh KP, Banerjee BD, Agarwal M, Ahmed RS. Therapeutic effect of yoga in patients with hypertension with reference to GST gene polymorphism. J Altern Complement Med. 2013;19:243–249.
    1. Hagins M, States R, Selfe T, Innes K. Effectiveness of yoga for hypertension: systematic review and meta‐analysis. Evid Based Complement Alternat Med. 2013;2013:649836.
    1. Schneider RH, Grim CE, Rainforth MV, Kotchen T, Nidich SI, Gaylord‐King C, Salerno JW, Kotchen JM, Alexander CN. Stress reduction in the secondary prevention of cardiovascular disease: randomized, controlled trial of transcendental meditation and health education in Blacks. Circ Cardiovasc Qual Outcomes. 2012;5:750–758.
    1. Nidich SI, Rainforth MV, Haaga DA, Hagelin J, Salerno JW, Travis F, Tanner M, Gaylord‐King C, Grosswald S, Schneider RH. A randomized controlled trial on effects of the Transcendental Meditation program on blood pressure, psychological distress, and coping in young adults. Am J Hypertens. 2009;22:1326–1331.
    1. Bai Z, Chang J, Chen C, Li P, Yang K, Chi I. Investigating the effect of transcendental meditation on blood pressure: a systematic review and meta‐analysis. J Hum Hypertens. 2015;29:653–662.
    1. Anderson JW, Liu C, Kryscio RJ. Blood pressure response to transcendental meditation: a meta‐analysis. Am J Hypertens. 2008;21:310–316.
    1. Rainforth MV, Schneider RH, Nidich SI, Gaylord‐King C, Salerno JW, Anderson JW. Stress reduction programs in patients with elevated blood pressure: a systematic review and meta‐analysis. Curr Hypertens Rep. 2007;9:520–528.
    1. Ospina MB, Bond K, Karkhaneh M, Tjosvold L, Vandermeer B, Liang Y. Meditation Practices for Health: State of the Research. Rockville, MD: Agency for Healthcare Research and Quality Evidence Report/Technology; Assessment Number 155; 2007.
    1. Urushidani S, Kuriyama A. Transcendental meditation and blood pressure. J Hum Hypertens. 2016;30:354.
    1. Brook RD, Appel LJ, Rubenfire M, Ogedegbe G, Bisognano JD, Elliott WJ, Fuchs FD, Hughes JW, Lackland DT, Staffileno BA, Townsend RR, Rajagopalan S; on behalf of the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Council on Nutrition, Physical Activity and Metabolism . Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the American Heart Association. Hypertension. 2013;61:1360–1383.
    1. Xiong GL, Doraiswamy PM. Does meditation enhance cognition and brain plasticity? Ann N Y Acad Sci. 2009;1172:63–69.
    1. Park J, Lyles RH, Bauer‐Wu S. Mindfulness meditation lowers muscle sympathetic nerve activity and blood pressure in African‐American males with chronic kidney disease. Am J Physiol Regul Integr Comp Physiol. 2014;307:R93–R101.
    1. Ospina MB, Bond K, Karkhaneh M, Buscemi N, Dryden DM, Barnes V, Carlson LE, Dusek JA, Shannahoff‐Khalsa D. Clinical trials of meditation practices in health care: characteristics and quality. J Altern Complement Med. 2008;14:1199–1213.
    1. United States. Public Health Service. Office of the Surgeon General, United States. Department of Health and Human Services . The Health Consequences of Smoking: 50 Years of Progress: A Report of the Surgeon General. Rockville, MD: US Department of Health and Human Services; 2014.
    1. Jha P, Ramasundarahettige C, Landsman V, Rostron B, Thun M, Anderson RN, McAfee T, Peto R. 21st‐century hazards of smoking and benefits of cessation in the United States. N Engl J Med. 2013;368:341–350.
    1. Quitting smoking among adults—United States, 2001–2010. MMWR Morb Mortal Wkly Rep. 2011;60:1513–1519.
    1. Davis JM, Fleming MF, Bonus KA, Baker TB. A pilot study on mindfulness based stress reduction for smokers. BMC Complement Altern Med. 2007;7:2.
    1. Davis JM, Mills DM, Stankevitz KA, Manley AR, Majeskie MR, Smith SS. Pilot randomized trial on mindfulness training for smokers in young adult binge drinkers. BMC Complement Altern Med. 2013;13:215.
    1. Davis JM, Goldberg SB, Anderson MC, Manley AR, Smith SS, Baker TB. Randomized trial on mindfulness training for smokers targeted to a disadvantaged population. Subst Use Misuse. 2014;49:571–585.
    1. Davis JM, Manley AR, Goldberg SB, Smith SS, Jorenby DE. Randomized trial comparing mindfulness training for smokers to a matched control. J Subst Abuse Treat. 2014;47:213–221.
    1. Brewer JA, Mallik S, Babuscio TA, Nich C, Johnson HE, Deleone CM, Minnix‐Cotton CA, Byrne SA, Kober H, Weinstein AJ, Carroll KM, Rounsaville B. Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug Alcohol Depend. 2011;119:72–80.
    1. Davis JM, Manley AR, Goldberg SB, Stankevitz KA, Smith SS. Mindfulness training for smokers via web‐based video instruction with phone support: a prospective observational study. BMC Complement Altern Med. 2015;15:95.
    1. Tang YY, Tang R, Posner MI. Brief meditation training induces smoking reduction. Proc Natl Acad Sci USA. 2013;110:13971–13975.
    1. Oikonomou MT, Arvanitis M, Sokolove RL. Mindfulness training for smoking cessation: a meta‐analysis of randomized‐controlled trials. J Health Psychol. 2016. April 4. pii: 1359105316637667. [Epub ahead of print]
    1. Haaga DA, Grosswald S, Gaylord‐King C, Rainforth M, Tanner M, Travis F, Nidich S, Schneider RH. Effects of the transcendental meditation program on substance use among university students. Cardiol Res Pract. 2011;2011:537101.
    1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112:2735–2752.
    1. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683–689.
    1. Reilly MP, Rader DJ. The metabolic syndrome: more than the sum of its parts? Circulation. 2003;108:1546–1551.
    1. Paul‐Labrador M, Polk D, Dwyer JH, Velasquez I, Nidich S, Rainforth M, Schneider R, Merz CN. Effects of a randomized controlled trial of transcendental meditation on components of the metabolic syndrome in subjects with coronary heart disease. Arch Intern Med. 2006;166:1218–1224.
    1. Khatri D, Mathur KC, Gahlot S, Jain S, Agrawal RP. Effects of yoga and meditation on clinical and biochemical parameters of metabolic syndrome. Diabetes Res Clin Pract. 2007;78:e9–e10.
    1. Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013;8:e62817.
    1. Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF‐kappaB. Aging (Albany NY). 2012;4:98–115.
    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867.
    1. Anderson J, Taylor AG. The metabolic syndrome and mind‐body therapies: a systematic review. J Nutr Metab. 2011;2011:276419.
    1. Castillo‐Richmond A, Schneider RH, Alexander CN, Cook R, Myers H, Nidich S, Haney C, Rainforth M, Salerno J. Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans. Stroke. 2000;31:568–573.
    1. Fields JZ, Walton KG, Schneider RH, Nidich S, Pomerantz R, Suchdev P, Castillo‐Richmond A, Payne K, Clark ET, Rainforth M. Effect of a multimodality natural medicine program on carotid atherosclerosis in older subjects: a pilot trial of Maharishi Vedic Medicine. Am J Cardiol. 2002;89:952–958.
    1. Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, McLanahan SM, Kirkeeide RL, Brand RJ, Gould KL. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet. 1990;336:129–133.
    1. Ornish D, Scherwitz LW, Billings JH, Brown SE, Gould KL, Merritt TA, Sparler S, Armstrong WT, Ports TA, Kirkeeide RL, Hogeboom C, Brand RJ. Intensive lifestyle changes for reversal of coronary heart disease. JAMA. 1998;280:2001–2007.
    1. Gupta SK, Sawhney RC, Rai L, Chavan VD, Dani S, Arora RC, Selvamurthy W, Chopra HK, Nanda NC. Regression of coronary atherosclerosis through healthy lifestyle in coronary artery disease patients—Mount Abu Open Heart Trial. Indian Heart J. 2011;63:461–469.
    1. Zhang Y, Li N, Sun J, Su Q. Effects of combined traditional Chinese exercises on blood pressure and arterial function of adult female hypertensive patients. Res Sports Med. 2013;21:98–109.
    1. Sivasankaran S, Pollard‐Quintner S, Sachdeva R, Pugeda J, Hoq SM, Zarich SW. The effect of a six‐week program of yoga and meditation on brachial artery reactivity: do psychosocial interventions affect vascular tone? Clin Cardiol. 2006;29:393–398.
    1. Vaccarino V, Kondwani KA, Kelley ME, Murrah NV, Boyd L, Ahmed Y, Meng YX, Gibbons GH, Hooper WC, De Staercke C, Quyyumi AA. Effect of meditation on endothelial function in Black Americans with metabolic syndrome: a randomized trial. Psychosom Med. 2013;75:591–599.
    1. Zamarra JW, Schneider RH, Besseghini I, Robinson DK, Salerno JW. Usefulness of the transcendental meditation program in the treatment of patients with coronary artery disease. Am J Cardiol. 1996;77:867–870.
    1. Ornish D, Scherwitz LW, Doody RS, Kesten D, McLanahan SM, Brown SE, DePuey E, Sonnemaker R, Haynes C, Lester J, McAllister GK, Hall RJ, Burdine JA, Gotto AM Jr. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA. 1983;249:54–59.
    1. Hartley L, Mavrodaris A, Flowers N, Ernst E, Rees K. Transcendental meditation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014;(12):CD010359.
    1. Hartley L, Flowers N, Lee MS, Ernst E, Rees K. Tai chi for primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014;(4):CD010366.
    1. Hartley L, Lee MS, Kwong JS, Flowers N, Todkill D, Ernst E, Rees K. Qigong for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2015;(6):CD010390.
    1. Hartley L, Dyakova M, Holmes J, Clarke A, Lee MS, Ernst E, Rees K. Yoga for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014;(5):CD010072.
    1. Alexander CN, Langer EJ, Newman RI, Chandler HM, Davies JL. Transcendental meditation, mindfulness, and longevity: an experimental study with the elderly. J Pers Soc Psychol. 1989;57:950–964.
    1. Barnes J, Schneider RH, Alexander CN, Rainforth M, Staggers F, Salerno J. Impact of transcendental meditation on mortality in older African Americans with hypertension—eight‐year follow‐up. J Soc Behav Pers. 2005;17:201–216.
    1. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995;333:1301–1307.
    1. Major outcomes in high‐risk hypertensive patients randomized to angiotensin‐converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid‐Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288:2981–2997.
    1. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A randomized trial of intensive versus standard blood‐pressure control. N Engl J Med. 2015;373:2103–2116.
    1. DuBroff R, Lad V, Murray‐Krezan C. A prospective trial of ayurveda for coronary heart disease: a pilot study. Altern Ther Health Med. 2015;21:52–62.
    1. Parswani MJ, Sharma MP, Iyengar S. Mindfulness‐based stress reduction program in coronary heart disease: a randomized control trial. Int J Yoga. 2013;6:111–117.
    1. Nehra DK, Sharma NR, Kumar P, Nehra S. Efficacy of mindfulness‐based stress reduction (MBSR) program in reducing perceived stress and health complaints in patients with coronary heart disease. Dysphrenia. 2014;5:19‐25.
    1. Delui MH, Yari M, Khouyinezhad G, Amini M, Bayazi MH. Comparison of cardiac rehabilitation programs combined with relaxation and meditation techniques on reduction of depression and anxiety of cardiovascular patients. Open Cardiovasc Med J. 2013;7:99–103.
    1. Tacón AM, McComb J, Caldera Y, Randolph P. Mindfulness meditation, anxiety reduction, and heart disease: a pilot study. Fam Community Health. 2003;26:25–33.
    1. Robert McComb JJ, Tacon A, Randolph P, Caldera Y. A pilot study to examine the effects of a mindfulness‐based stress‐reduction and relaxation program on levels of stress hormones, physical functioning, and submaximal exercise responses. J Altern Complement Med. 2004;10:819–827.
    1. Sullivan MJ, Wood L, Terry J, Brantley J, Charles A, McGee V, Johnson D, Krucoff MW, Rosenberg B, Bosworth HB, Adams K, Cuffe MS. The Support, Education, and Research in Chronic Heart Failure Study (SEARCH): a mindfulness‐based psychoeducational intervention improves depression and clinical symptoms in patients with chronic heart failure. Am Heart J. 2009;157:84–90.
    1. Younge JO, Gotink RA, Baena CP, Roos‐Hesselink JW, Hunink MG. Mind‐body practices for patients with cardiac disease: a systematic review and meta‐analysis. Eur J Prev Cardiol. 2015;22:1385–1398.
    1. Olex S, Newberg A, Figueredo VM. Meditation: should a cardiologist care? Int J Cardiol. 2013;168:1805–1810.
    1. Husten L. Archives decides at last minute not to publish scheduled paper. Cardiobrief. Available at: . Accessed June 27, 2011.
    1. Kinra S, Ebrahim S, Pocock SJ, Chaturvedi N, Roberts IG, Acharya AK, Hughes AD. Development and evaluation of a yoga‐based cardiac rehabilitation programme (Yoga‐CaRe) for secondary prevention of myocardial infarction. 2017. Available at: . Accessed February 12, 2017.

Source: PubMed

3
구독하다