An Immature Science: Intensive Care for Infants Born at ≤23 Weeks of Gestation

Matthew A Rysavy, Katrin Mehler, André Oberthür, Johan Ågren, Satoshi Kusuda, Patrick J McNamara, Regan E Giesinger, Angela Kribs, Erik Normann, Susan J Carlson, Jonathan M Klein, Carl H Backes, Edward F Bell, Matthew A Rysavy, Katrin Mehler, André Oberthür, Johan Ågren, Satoshi Kusuda, Patrick J McNamara, Regan E Giesinger, Angela Kribs, Erik Normann, Susan J Carlson, Jonathan M Klein, Carl H Backes, Edward F Bell

No abstract available

Keywords: extremely preterm birth; outcomes; periviable birth; physiology.

Figures

Figure 1.. Active Treatment and Survival for Liveborn Infants at 22 Weeks in the US

Active treatment is defined as respiratory support (including face mask ventilation, nasal continuous positive airway pressure, endotracheal intubation, surfactant therapy, or mechanical ventilation), chest compressions, or epinephrine. Survival is to hospital discharge or 1 year. The denominator includes all live births, including deaths that occurred in the delivery room. Data are from hospitals participating in the Vermont-Oxford Network.

Figure 2.. Morbidities of Infants born Extremely Preterm in the Japanese Neonatal Research Network

In-hospital morbidities for live born infants with extreme prematurity in the Japanese Neonatal Research Network 2003–2017 by gestational age at birth. Air leak includes pneumothorax and pneumomediastinum. Sepsis was defined as a positive blood culture at any time after birth. Intraventricular hemorrhage (IVH) includes all grades. Persistent pulmonary hypertension of the newborn (PPHN) was defined as a right-to-left shunt at the foramen ovale and/or ductus arteriosus, without cardiac anatomical abnormality, diagnosed by echocardiography. Necrotizing enterocolitis (NEC) was defined as Bell stage II or greater; intestinal perforation (IP) was diagnosed if free air in the abdomen for a reason besides NEC. The denominator includes all live births (n=943 at 22 weeks; n=2712 at 23 weeks; n=3764 at 24 weeks; n=4366 at 25 weeks; n=5278 at 26 weeks; n=6161 at 27 weeks).