Could CGRP Antagonists Be Helpful in the Fight Against COVID-19?

Carrie E Robertson, Carrie E Robertson

No abstract available

Keywords: ARDS; CGRP; COVID-19; SARS-CoV-2; calcitonin gene-related peptide.

References

    1. Szperka CL, Ailani J, Barmherzig R, et al. Migraine care in the era of COVID‐19: Clinical pearls and plea to insurers. Headache. 2020;60:833‐842.
    1. Kee Z, Kodji X, Brain SD. The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 2018;9:1249.
    1. Russell FA, King R, Smillie SJ, Kodji X, Brain SD. Calcitonin gene‐related peptide: Physiology and pathophysiology. Physiol Rev. 2014;94:1099‐1142.
    1. Guo Z, Liu N, Chen L, Zhao X, Li MR. Independent roles of CGRP in cardioprotection and hemodynamic regulation in ischemic postconditioning. Eur J Pharmacol. 2018;828:18‐25.
    1. Lo CCW, Moosavi SM, Bubb KJ. The regulation of pulmonary vascular tone by neuropeptides and the implications for pulmonary hypertension. Front Physiol. 2018;9:1167.
    1. Lange M, Enkhbaatar P, Traber DL, et al. Role of calcitonin gene‐related peptide (CGRP) in ovine burn and smoke inhalation injury. J Appl Physiol. 2009;107:176‐184.
    1. Aoki‐Nagase T, Nagase T, Oh‐Hashi Y, et al. Calcitonin gene‐related peptide mediates acid‐induced lung injury in mice. Respirology. 2007;12:807‐813.
    1. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395:507‐513.
    1. Henderson LA, Canna SW, Schulert GS, et al. On the alert for cytokine storm: Immunopathology in COVID‐19. Arthritis Rheumatol. 2020. doi: 10.1002/art.41285.
    1. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. The cytokine release syndrome (CRS) of severe COVID‐19 and Interleukin‐6 receptor (IL‐6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. 2020;55:105954. doi: 10.1016/j.ijantimicag.2020.105954.
    1. Chen X, Zhao B, Qu Y, et al. Detectable serum SARS‐CoV‐2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL‐6) level in critically ill COVID‐19 patients. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa449.
    1. Ascierto PA, Fox B, Urba W, et al. Insights from immuno‐oncology: The Society for Immunotherapy of Cancer Statement on access to IL‐6‐targeting therapies for COVID‐19. J Immunother Cancer. 2020;8:e000878.
    1. Sakuta H, Inaba K, Muramatsu S. Calcitonin gene‐related peptide enhances cytokine‐induced IL‐6 production by fibroblasts. Cell Immunol. 1995;165:20‐25.
    1. Available at: . Accessed April 4, 2020.
    1. Wang Y, Liu Z, Ge X, et al. Neuropathic pain releasing calcitonin gene related peptide protects against stroke in rats. Am J Transl Res. 2020;12:54‐69.

Source: PubMed

스폰서 및 공동 작업자

건강 상태

약물 개입

3
구독하다