Bone-defects healing by high-molecular hyaluronic acid: preliminary results
Alberto Baldini, Davide Zaffe, Gabriella Nicolini, Alberto Baldini, Davide Zaffe, Gabriella Nicolini
Abstract
AIM.: The aim of this study is to evaluate the capability of Hyaloss™ matrix (Fab - Fidia Advanced Biopolymers - Pd - Italy), a biomaterial based on hyaluronic acid, used as organic scaffold in bone repair in post-extractive defects.
Materials and methods: 20 post-extractive sockets were selected, with similar size defects in the same patient and in the same hemiarch. Hyaluronic acid with high molecular weight (Hyaloss™ matrix, Fab - Pd - Italy) was mixed with autologous bone obtained using Safescraper(®) curve (Meta - Re - Italy) to repair post-extractive sites. Safescraper(®) is a cutting edge system that allows to the collection of autologous bone without using traditional, incision-based collection techniques, which could cause discomfort to the patient.
Results: Clinical and hystological evaluations were performed, four months after grafting, in the maxilla and in the mandible. From a clinical point of view Hyaloss™ matrix mixed with autologous bone and patient's blood becomes a substance similar to gel, which is easy to insert in to the defect. From a hystological point of view, in the treated site there is the presence of an erosive activity, with accelerated angiogenetic and bone remodelling activities.
Conclusions: The preliminary results show an acceleration of the bone deposit process and of its remodelling due to the presence of Hyaloss™ matrix, which, from a clinical point of view, improves the handling and application of the bone matrix inside the defects and, from a hystologic point of view makes it possible to obtain bone regeneration in less time when it is used with autologous bone.
Keywords: autologous bone; bone; bone defect healing; bone graft; hyaluronic acid.
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Source: PubMed