Extrafine triple therapy in patients with symptomatic COPD and history of one moderate exacerbation

Abstract

In patients with symptomatic COPD, severe/very severe airflow limitation, and a history of one moderate (and no severe) exacerbation, ICS-containing triple therapy significantly reduces exacerbation risk overall versus single or double maintenance therapy http://ow.ly/VgJC30o9pXC

Conflict of interest statement

Conflict of interest: D. Singh reports personal fees from Chiesi, during the conduct of these studies; grants and personal fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Glenmark, Johnson and Johnson, Merck, NAPP, Novartis, Pfizer, Takeda, Teva, Theravance and Verona, personal fees from Genentech and Skeypharma, outside the submitted work. Conflict of interest: L.M. Fabbri reports personal fees and non-financial support from AstraZeneca, GSK, Novartis, Menarini, Boehringer Ingelheim, Zambon and Pearl Therapeutics, grants, personal fees and non-financial support from Chiesi, non-financial support from Dompe, outside the submitted work. Conflict of interest: M. Corradi reports grants and personal fees from Chiesi Farmaceutici SpA, outside the submitted work. Conflict of interest: G. Georges was an employee of Chiesi USA, Inc., during the conduct of these studies. Conflict of interest: A. Guasconi was an employee of Chiesi Farmaceutici S.p.A, during the conduct of these studies. Conflict of interest: S. Vezzoli was an employee of Chiesi Farmaceutici S.p.A, during the conduct of these studies. Conflict of interest: S. Petruzzelli was an employee of Chiesi Farmaceutici S.p.A, during the conduct of these studies. Conflict of interest: A. Papi reports fees for board membership, consultancy, payment for lectures, grants for research and travel expenses reimbursement from Chiesi, AstraZeneca, GlaxoSmithKline, Boehringer Ingelheim, Mundipharma and TEVA, fees for lectures and travel expenses reimbursement from Menarini, Novartis and Zambon, grants for research from Sanofi, outside the submitted work.

Figures

FIGURE 1

a) Adjusted annual rate of moderate-to-severe chronic obstructive pulmonary disease exacerbations (intention-to-treat population). b) Between-treatment differences in St George's Respiratory Questionnaire (SGRQ) total score and forced expiratory volume in 1 s (FEV1) at week 52 and overall, and SGRQ responders at week 52 (intention-to-treat population). Data are adjusted mean differences or odds ratios with 95% confidence intervals and p-values. SGRQ responders are patients with a decrease from baseline in SGRQ total score of at least 4 units. BDP: beclometasone dipropionate; FF: formoterol fumarate; G: glycopyrronium; IND/GLY: indacaterol/glycopyrronium.