The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies
Cynthia Gyamfi, Amanda L Horton, Valerija Momirova, Dwight J Rouse, Steve N Caritis, Alan M Peaceman, Anthony Sciscione, Paul J Meis, Catherine Y Spong, Mitchell Dombrowski, Baha Sibai, Michael W Varner, Jay D Iams, Brian M Mercer, Marshall W Carpenter, Julie Lo, Susan M Ramin, Mary Jo O'Sullivan, Menachem Miodovnik, Deborah Conway, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, R Berkowitz, F Malone, S South, L Paley, S Bousleiman, V Carmona, M D'Alton, V Pemberton, J Thorp, K Boggess, K Dorman, S Timlin, K Moise, W Andrews, J Sheppard, A Northen, J Hauth, E Daugherty, M Cotroneo, H Simhan, K Lain, M Dinsmoor, G Mallett, P Simon, M Huntley, M Ramos, M Socol, M DiVito, M Hoffman, S Wilson, C Tocci, M Lake, M Talucci, K Anderson, F Porter, A Guzman, K Jolley, S Quinn, M Belfort, E Taggart, F Johnson, C Latimer, M Landon, C Milluzzi, C Heggie, H Ehrenberg, B Stetzer, A Merlino, P Catalano, Y Sorokin, G Norman, C Sudz, S Blackwell, D Allard, H Silver, J Tillinghast, K Leveno, L Moseley, D Soebbing-Cross, J Martinez, B Glenn-Cole, L Gilstrap, M C Day, R Ramsey, C Alfonso, S Beydoun, N Elder, T Siddiq, O Langer, S Nicholson, A Moawad, P Jones, M Lindheimer, M Harper, M Swain, K Johnson, K Lanier, C Leftwich, E Mueller-Heubach, E Thom, L Leuchtenburg, A Das, M Klebanoff, S Pagliaro, D McNellis, Cynthia Gyamfi, Amanda L Horton, Valerija Momirova, Dwight J Rouse, Steve N Caritis, Alan M Peaceman, Anthony Sciscione, Paul J Meis, Catherine Y Spong, Mitchell Dombrowski, Baha Sibai, Michael W Varner, Jay D Iams, Brian M Mercer, Marshall W Carpenter, Julie Lo, Susan M Ramin, Mary Jo O'Sullivan, Menachem Miodovnik, Deborah Conway, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, R Berkowitz, F Malone, S South, L Paley, S Bousleiman, V Carmona, M D'Alton, V Pemberton, J Thorp, K Boggess, K Dorman, S Timlin, K Moise, W Andrews, J Sheppard, A Northen, J Hauth, E Daugherty, M Cotroneo, H Simhan, K Lain, M Dinsmoor, G Mallett, P Simon, M Huntley, M Ramos, M Socol, M DiVito, M Hoffman, S Wilson, C Tocci, M Lake, M Talucci, K Anderson, F Porter, A Guzman, K Jolley, S Quinn, M Belfort, E Taggart, F Johnson, C Latimer, M Landon, C Milluzzi, C Heggie, H Ehrenberg, B Stetzer, A Merlino, P Catalano, Y Sorokin, G Norman, C Sudz, S Blackwell, D Allard, H Silver, J Tillinghast, K Leveno, L Moseley, D Soebbing-Cross, J Martinez, B Glenn-Cole, L Gilstrap, M C Day, R Ramsey, C Alfonso, S Beydoun, N Elder, T Siddiq, O Langer, S Nicholson, A Moawad, P Jones, M Lindheimer, M Harper, M Swain, K Johnson, K Lanier, C Leftwich, E Mueller-Heubach, E Thom, L Leuchtenburg, A Das, M Klebanoff, S Pagliaro, D McNellis
Abstract
Objective: To compare the rates of gestational diabetes among women who received serial doses of 17-alpha hydroxyprogesterone caproate vs placebo.
Study design: Secondary analysis of 2 double-blind randomized placebo-controlled trials of 17-alpha hydroxyprogesterone caproate given to women at risk for preterm delivery. The incidence of gestational diabetes was compared between women who received 17-alpha hydroxyprogesterone caproate or placebo.
Results: We included 1094 women; 441 had singleton and 653 had twin gestations. Combining the 2 studies, 616 received 17-alpha hydroxyprogesterone caproate and 478 received placebo. Among singleton and twin pregnancies, rates of gestational diabetes were similar in women receiving 17-alpha hydroxyprogesterone caproate vs placebo (5.8% vs 4.7%; P = .64 and 7.4% vs 7.6%; P = .94, respectively). In the multivariable model, progesterone was not associated with gestational diabetes (adjusted odds ratio, 1.04; 95% confidence interval, 0.62-1.73).
Conclusion: Weekly administration of 17-alpha hydroxyprogesterone caproate is not associated with higher rates of gestational diabetes in either singleton or twin pregnancies.
Figures
Source: PubMed