Beneficial Effect of Oligofructose-Enriched Inulin on Vitamin D and E Status in Children with Celiac Disease on a Long-Term Gluten-Free Diet: A Preliminary Randomized, Placebo-Controlled Nutritional Intervention Study

Natalia Drabińska, Urszula Krupa-Kozak, Paweł Abramowicz, Elżbieta Jarocka-Cyrta, Natalia Drabińska, Urszula Krupa-Kozak, Paweł Abramowicz, Elżbieta Jarocka-Cyrta

Abstract

Prebiotics have been shown to improve absorption of some nutrients, including vitamins. This pilot study evaluated the effect of the prebiotic oligofructose-enriched inulin (Synergy 1) on fat-soluble vitamins status, parathormone, and calcium-related elements in pediatric celiac disease (CD) patients (n = 34) on a strict gluten-free diet (GFD). Participants were randomized into a group receiving 10 g of Synergy 1 or placebo (maltodextrin) together with a GFD. At baseline and after 3 months of intervention, 25-hydroxyvitamin D [25(OH)D], parathormone, vitamin E and A, calcium, phosphate, magnesium, total protein, and albumin were determined. Concentration of 25(OH)D increased significantly (p < 0.05) by 42% in CD patients receiving Synergy 1 in GFD, whereas no change was observed in placebo. Vitamin D status reached an optimal level in 46% of patients receiving Synergy 1. No significant difference in parathormone, calcium, and phosphate levels was observed. Concentration of vitamin E increased significantly (p < 0.05) by 19% in patients receiving Synergy 1, but not in the placebo. Vitamin A levels were not changed. Supplementation of GFD with Synergy 1 improved vitamin D and vitamin E status in children and adolescents with CD and could be considered a novel complementary method of management of fat-soluble vitamins deficiency in pediatric CD patients.

Keywords: celiac disease; dietary intervention; gluten-free diet; inulin; prebiotics; vitamin D; vitamin E.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Box-and-whisker plots of 25(OH)D plasma concentration comparison between groups supplemented with Synergy 1 and placebo at baseline (T0) and after 3 months of supplementation (T1) using the Mann–Whitney test. Data are expressed as median (horizontal line), percentiles (box), and range (whisker).
Figure 2
Figure 2
Plasma concentrations of vitamin A and E in individual participants before (T0) and after the intervention (T1), expressed as mean ± SD.

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Source: PubMed

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