Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings
Diabetic Retinopathy Clinical Research Network, Alexander J Brucker, Haijing Qin, Andrew N Antoszyk, Roy W Beck, Neil M Bressler, David J Browning, Michael J Elman, Adam R Glassman, Jeffrey G Gross, Craig Kollman, John A Wells 3rd, David Browning, Andrew N Antoszyk, Danielle R Brooks, Melissa K Cowen, Alison H Stallings, Jennifer V Helms, Angela K Price, Heather L Murphy, Rachel E Pierce, Karen A Ruiz, Richard J George, Michael D McOwen, Uma M Balasubramaniam, Michele E Powers, Donna McClain, Loraine M Clark, Linda M Davis, Jon M Braverman, Antonio P Ciardella, Leif S Ryman, Brenner F Dixon, Melissa A Stillberger, Janelle Dane Zapata, Rosemary C Rhodes, Debbie M Brown, Michael J Elman, Robert Z Raden, Michelle D Sloan, Tammy M Butcher, JoAnn Starr, Dena Salfer-Firestone, Teresa Coffey, Pamela V Singletary, Nancy Gore, Terri Cain, Peter Sotirakos, Giorya Shabi, Howard S Lazarus, Debra Paige Bunch, Angela D Ridge, Kelly Booth, Liana C Davis, Margaret Trimble, Jay Moore, Gary E Fish, Robert C Wang, Jean Arnwine, Sally Arceneaux, Brenda Sanchez, Keith Gray, Kimberly Cummings, Hank Aguado, Diana Jaramillo, Jeffrey G Gross, Barron C Fishburne, Michael A Magee, Amy M Flowers, Peggy W Cummings, Regina A Gabriel, Kristin K Bland, Heidi K Lovit, Chris N Mallet, Randall L Price, Rick Christoff, Paul Andrew Edwards, Michael D Ober, Sheila M Rock, Mary K Monk, Janet Murphy, Dorena F Wilson, Mark Croswell, Brian A Rusinek, Lisa M Schillace, Tracy A Troszak, Bradley A Stern, John A Wells, W Lloyd Clark, Marcia D Gridine, Cassie P Cahill, Amy B Hickman, Robbin Spivey, Judy E Kim, Dennis P Han, William J Wirostko, Dawn Alvarez, Troy S Drescher, Rowena J Knapp, Vicki Barwick, Judy Flanders, Dennis B Backes, Kathy J Selchert, Joseph R Beringer, Kristy L Keller, Clement K Chan, David M Salib, Steven G Lin, Asha S D Nuthi, Eric D Dickerson, Trina L Keith, Kelly E Sage, Teri A Andresen, Isela Aldana, Tina B Wiskirchen, Sandra U Castillo, Sara Warren, Kara Rollins, Kenneth M Huff, Donna J Chesbrough, Sabrina E Bretz, George S Sharuk, Deborah K Schlossman, Ann Kopple, Margaret E Stockman, Robert W Cavicchi, Ellen L Casazza, Joseph T Fan, Michael E Rauser, Kara E Rollins, Carrousel J Corliss, Sarina L Osuna, William H Kiernan, Johnathan D Cloud, William Milam, Gene Saldana, G Robert Hampton, Samuel C Spalding, Paul F Torrisi, Bryan K Rutledge, Cindy J Grinnell, Fayth M DiSano, Lynn M Kwasniewski, Tanya C Czajak, Lynn A Capone, Bob Corey, Peter B Hay, Jose A Martinez, Chris A Montesclaros, Carrie E Odean, Richard A Sabo, Charles A Garcia, John McCrary, Elizabeth Garibay, Emma M Lessieur, Penelope Reyes Villeda, Hugo L Paz, Juan P Montoya, Cecilia Vi Nguyen, Edgardo Santisbon, Sindya M Cerda, Rafael A Lopez, Angela Ramirez, Scott M Friedman, Kelly A Blackmer, Jolleen S Key, Steve Carlton, Damanda A Fagan, Virginia Gregory, Thomas M Aaberg, Sarita Scott, Debra Markus, Sandy Kronlein, Sandra Lewis, Michel Shami, Phyllis Pusser, Carrie L Tarter, Linda Squires, Thom F Wentlandt, Mary Elizabeth R Hartnett, Seema Garg, Cassandra J Barnhart, Debra Cantrell, Rona Lyn Esquejo, Kelly D Shields, Alice T Lyon, Lori A Kaminski, Lori E Ackatz, Laima M O'Donnell, Jonathan Shankle, Frederick H Davidorf, Alicia M Green, Jerilyn G Perry, Chhanda G Chaudhuri, Scott J Savage, John H Drouilhet, Susan Pelke, Deborah Nobler, Ivan R Batlle, Karla A Batlle, Gwendolyn M Williams, Michelle Parks, Joseph Googe, Tod A McMillan, Nicholas G Anderson, Stephen L Perkins, Christina T Higdon, Cecile Hunt, Jerry K Whetstone, Michael Jacobus, Misty Moore, Paul A Blais, Michael J Cooney, John A Sorenson, Leandro Maranan, Maria Sco, Eugene I Agresta, Caldwell W Smith, Collin L DuCoty, Sylvia Varadian, Claudia Salinas, Erika Banalewicz, Mark Hamel, Alex L Nagle, Melvin Chen, Keye L Wong, Christine Holland, Karen Hagin, Mark Sneath, Rosa Miller, Roy W Beck, Adam R Glassman, Joy Barros, Brian B Dale, Sharon R Constantine, Simone S Dupre, Allison R Edwards, Meagan Hutton, Paula A Johnson, Craig Kollman, Lee Anne Lester, Brenda L Loggins, Shannon L McClellan, Patricia Murtaugh, Pamela S Moke, Haijing Qin, Rosa Pritchard, Hiram Ramirez, Eureca Scott, Cynthia R Stockdale, Matthew D Davis, Ronald P Danis, Larry Hubbard, James Reimers, Pamela Vargo, Ericka Moeller, Dawn Myers, Michael Daywalt, Neil M Bressler, Lloyd P Aiello, Donald F Everett, Päivi H Miskala, Alexander J Brucker, David Browning, Emily Y Chew, Ronald P Danis, Julia A Haller, Lloyd P Aiello, Carl W Baker, Neil M Bressler, Debra Paige Bunch, Donald F Everett, Frederick Ferris, Adam R Glassman, Dennis M Marcus, Greg Anderson, Steve Carlton, Tom Gardner, Jeffrey G Gross, Helen K Li, Angela K Price, Päivi Miskala, Don S Fong, Neil M Bressler, Lloyd P Aiello, Roy W Beck, Abdhish Bhavsar, Ronald P Danis, Matthew D Davis, Donald F Everett, Frederick L Ferris, Joan Fish, Scott Friedman, Adam R Glassman, Andreas Lauer, David M Brown, David J Browning, Michael J Elman, Kim McLead, Päivi H Miskala, Cynthia J Grinnell, John Connett, Deborah Barnbaum, Harry W Flynn Jr, Robert N Frank, Saul Genuth, Lee Jampol, Stephen Wisniewski, Jeanette Resnick, Diabetic Retinopathy Clinical Research Network, Alexander J Brucker, Haijing Qin, Andrew N Antoszyk, Roy W Beck, Neil M Bressler, David J Browning, Michael J Elman, Adam R Glassman, Jeffrey G Gross, Craig Kollman, John A Wells 3rd, David Browning, Andrew N Antoszyk, Danielle R Brooks, Melissa K Cowen, Alison H Stallings, Jennifer V Helms, Angela K Price, Heather L Murphy, Rachel E Pierce, Karen A Ruiz, Richard J George, Michael D McOwen, Uma M Balasubramaniam, Michele E Powers, Donna McClain, Loraine M Clark, Linda M Davis, Jon M Braverman, Antonio P Ciardella, Leif S Ryman, Brenner F Dixon, Melissa A Stillberger, Janelle Dane Zapata, Rosemary C Rhodes, Debbie M Brown, Michael J Elman, Robert Z Raden, Michelle D Sloan, Tammy M Butcher, JoAnn Starr, Dena Salfer-Firestone, Teresa Coffey, Pamela V Singletary, Nancy Gore, Terri Cain, Peter Sotirakos, Giorya Shabi, Howard S Lazarus, Debra Paige Bunch, Angela D Ridge, Kelly Booth, Liana C Davis, Margaret Trimble, Jay Moore, Gary E Fish, Robert C Wang, Jean Arnwine, Sally Arceneaux, Brenda Sanchez, Keith Gray, Kimberly Cummings, Hank Aguado, Diana Jaramillo, Jeffrey G Gross, Barron C Fishburne, Michael A Magee, Amy M Flowers, Peggy W Cummings, Regina A Gabriel, Kristin K Bland, Heidi K Lovit, Chris N Mallet, Randall L Price, Rick Christoff, Paul Andrew Edwards, Michael D Ober, Sheila M Rock, Mary K Monk, Janet Murphy, Dorena F Wilson, Mark Croswell, Brian A Rusinek, Lisa M Schillace, Tracy A Troszak, Bradley A Stern, John A Wells, W Lloyd Clark, Marcia D Gridine, Cassie P Cahill, Amy B Hickman, Robbin Spivey, Judy E Kim, Dennis P Han, William J Wirostko, Dawn Alvarez, Troy S Drescher, Rowena J Knapp, Vicki Barwick, Judy Flanders, Dennis B Backes, Kathy J Selchert, Joseph R Beringer, Kristy L Keller, Clement K Chan, David M Salib, Steven G Lin, Asha S D Nuthi, Eric D Dickerson, Trina L Keith, Kelly E Sage, Teri A Andresen, Isela Aldana, Tina B Wiskirchen, Sandra U Castillo, Sara Warren, Kara Rollins, Kenneth M Huff, Donna J Chesbrough, Sabrina E Bretz, George S Sharuk, Deborah K Schlossman, Ann Kopple, Margaret E Stockman, Robert W Cavicchi, Ellen L Casazza, Joseph T Fan, Michael E Rauser, Kara E Rollins, Carrousel J Corliss, Sarina L Osuna, William H Kiernan, Johnathan D Cloud, William Milam, Gene Saldana, G Robert Hampton, Samuel C Spalding, Paul F Torrisi, Bryan K Rutledge, Cindy J Grinnell, Fayth M DiSano, Lynn M Kwasniewski, Tanya C Czajak, Lynn A Capone, Bob Corey, Peter B Hay, Jose A Martinez, Chris A Montesclaros, Carrie E Odean, Richard A Sabo, Charles A Garcia, John McCrary, Elizabeth Garibay, Emma M Lessieur, Penelope Reyes Villeda, Hugo L Paz, Juan P Montoya, Cecilia Vi Nguyen, Edgardo Santisbon, Sindya M Cerda, Rafael A Lopez, Angela Ramirez, Scott M Friedman, Kelly A Blackmer, Jolleen S Key, Steve Carlton, Damanda A Fagan, Virginia Gregory, Thomas M Aaberg, Sarita Scott, Debra Markus, Sandy Kronlein, Sandra Lewis, Michel Shami, Phyllis Pusser, Carrie L Tarter, Linda Squires, Thom F Wentlandt, Mary Elizabeth R Hartnett, Seema Garg, Cassandra J Barnhart, Debra Cantrell, Rona Lyn Esquejo, Kelly D Shields, Alice T Lyon, Lori A Kaminski, Lori E Ackatz, Laima M O'Donnell, Jonathan Shankle, Frederick H Davidorf, Alicia M Green, Jerilyn G Perry, Chhanda G Chaudhuri, Scott J Savage, John H Drouilhet, Susan Pelke, Deborah Nobler, Ivan R Batlle, Karla A Batlle, Gwendolyn M Williams, Michelle Parks, Joseph Googe, Tod A McMillan, Nicholas G Anderson, Stephen L Perkins, Christina T Higdon, Cecile Hunt, Jerry K Whetstone, Michael Jacobus, Misty Moore, Paul A Blais, Michael J Cooney, John A Sorenson, Leandro Maranan, Maria Sco, Eugene I Agresta, Caldwell W Smith, Collin L DuCoty, Sylvia Varadian, Claudia Salinas, Erika Banalewicz, Mark Hamel, Alex L Nagle, Melvin Chen, Keye L Wong, Christine Holland, Karen Hagin, Mark Sneath, Rosa Miller, Roy W Beck, Adam R Glassman, Joy Barros, Brian B Dale, Sharon R Constantine, Simone S Dupre, Allison R Edwards, Meagan Hutton, Paula A Johnson, Craig Kollman, Lee Anne Lester, Brenda L Loggins, Shannon L McClellan, Patricia Murtaugh, Pamela S Moke, Haijing Qin, Rosa Pritchard, Hiram Ramirez, Eureca Scott, Cynthia R Stockdale, Matthew D Davis, Ronald P Danis, Larry Hubbard, James Reimers, Pamela Vargo, Ericka Moeller, Dawn Myers, Michael Daywalt, Neil M Bressler, Lloyd P Aiello, Donald F Everett, Päivi H Miskala, Alexander J Brucker, David Browning, Emily Y Chew, Ronald P Danis, Julia A Haller, Lloyd P Aiello, Carl W Baker, Neil M Bressler, Debra Paige Bunch, Donald F Everett, Frederick Ferris, Adam R Glassman, Dennis M Marcus, Greg Anderson, Steve Carlton, Tom Gardner, Jeffrey G Gross, Helen K Li, Angela K Price, Päivi Miskala, Don S Fong, Neil M Bressler, Lloyd P Aiello, Roy W Beck, Abdhish Bhavsar, Ronald P Danis, Matthew D Davis, Donald F Everett, Frederick L Ferris, Joan Fish, Scott Friedman, Adam R Glassman, Andreas Lauer, David M Brown, David J Browning, Michael J Elman, Kim McLead, Päivi H Miskala, Cynthia J Grinnell, John Connett, Deborah Barnbaum, Harry W Flynn Jr, Robert N Frank, Saul Genuth, Lee Jampol, Stephen Wisniewski, Jeanette Resnick
Abstract
Objective: To compare the effects of single-sitting vs 4-sitting panretinal photocoagulation (PRP) on macular edema in subjects with severe nonproliferative or early proliferative diabetic retinopathy with relatively good visual acuity and no or mild center-involved macular edema.
Methods: Subjects were treated with 1 sitting or 4 sittings of PRP in a nonrandomized, prospective, multicentered clinical trial. Main Outcome Measure Central subfield thickness on optical coherence tomography (OCT).
Results: Central subfield thickness was slightly greater in the 1-sitting group (n = 84) than in the 4-sitting group (n = 71) at the 3-day (P = .01) and 4-week visits (P = .003). At the 34-week primary outcome visit, the slight differences had reversed, with the thickness being slightly greater in the 4-sitting group than in the 1-sitting group (P = .06). Visual acuity differences paralleled OCT differences.
Conclusions: Our results suggest that clinically meaningful differences are unlikely in OCT thickness or visual acuity following application of PRP in 1 sitting compared with 4 sittings in subjects in this cohort. More definitive results would require a large randomized trial. Application to Clinical Practice These results suggest PRP costs to some patients in terms of travel and lost productivity as well as to eye care providers could be reduced.
Trial registration: clinicaltrials.gov Identifier: NCT00687154.
Conflict of interest statement
Conflicts of interest statement: None
Figures
Source: PubMed