Insulin resistance influences central opioid activity in polycystic ovary syndrome
Alison Berent-Spillson, Tiffany Love, Rodica Pop-Busui, MaryFran Sowers, Carol C Persad, Kathryn P Pennington, Aimee D Eyvazaddeh, Vasantha Padmanabhan, Jon-Kar Zubieta, Yolanda R Smith, Alison Berent-Spillson, Tiffany Love, Rodica Pop-Busui, MaryFran Sowers, Carol C Persad, Kathryn P Pennington, Aimee D Eyvazaddeh, Vasantha Padmanabhan, Jon-Kar Zubieta, Yolanda R Smith
Abstract
This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Source: PubMed