Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
Pengyuan Liu, Haris G Vikis, Daolong Wang, Yan Lu, Yian Wang, Ann G Schwartz, Susan M Pinney, Ping Yang, Mariza de Andrade, Gloria M Petersen, Jonathan S Wiest, Pamela R Fain, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela Seminara, John Minna, Joan E Bailey-Wilson, Xifeng Wu, Margaret R Spitz, Timothy Eisen, Richard S Houlston, Christopher I Amos, Marshall W Anderson, Ming You, Pengyuan Liu, Haris G Vikis, Daolong Wang, Yan Lu, Yian Wang, Ann G Schwartz, Susan M Pinney, Ping Yang, Mariza de Andrade, Gloria M Petersen, Jonathan S Wiest, Pamela R Fain, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela Seminara, John Minna, Joan E Bailey-Wilson, Xifeng Wu, Margaret R Spitz, Timothy Eisen, Richard S Houlston, Christopher I Amos, Marshall W Anderson, Ming You
Abstract
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
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Source: PubMed