Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
Harry J Gould 3rd, Paige R Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K Brady, Dennis Paul, Harry J Gould 3rd, Paige R Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K Brady, Dennis Paul
Abstract
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
Trial registration: ClinicalTrials.gov NCT01414608.
Keywords: advanced-stage cervical cancer; sodium channels; sodium pumps; targeted osmotic lysis.
Conflict of interest statement
D.P., P.R.M. and H.J.G.III are cofounders and managing members of Oleander Medical Technologies LLC.
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