Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial
Tjitske S R Van Engelen, Jack Yang, Bastiaan W Haak, Peter I Bonta, Tom Van Der Poll, W Joost Wiersinga, CAST study group, Tjitske S R van Engelen, Jack Yang, Bastiaan W Haak, Floor Hugenholtz, Peter I Bonta, Christof J Majoor, Cornelis van 't Veer, E Marleen Kemper, Elisabeth H Bel, Tom van der Poll, W Joost Wiersinga, Tjitske S R Van Engelen, Jack Yang, Bastiaan W Haak, Peter I Bonta, Tom Van Der Poll, W Joost Wiersinga, CAST study group, Tjitske S R van Engelen, Jack Yang, Bastiaan W Haak, Floor Hugenholtz, Peter I Bonta, Christof J Majoor, Cornelis van 't Veer, E Marleen Kemper, Elisabeth H Bel, Tom van der Poll, W Joost Wiersinga
Abstract
Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.1 Disruption and subsequent dysregulation of gut microbiota-related immunologic processes have also been linked to disease severity and response to treatment.2.
Trial registration: ClinicalTrials.gov NCT03051698.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Source: PubMed