Comparison of prediction model for cardiovascular autonomic dysfunction using artificial neural network and logistic regression analysis

Zi-Hui Tang, Juanmei Liu, Fangfang Zeng, Zhongtao Li, Xiaoling Yu, Linuo Zhou, Zi-Hui Tang, Juanmei Liu, Fangfang Zeng, Zhongtao Li, Xiaoling Yu, Linuo Zhou

Abstract

Background: This study aimed to develop the artificial neural network (ANN) and multivariable logistic regression (LR) analyses for prediction modeling of cardiovascular autonomic (CA) dysfunction in the general population, and compare the prediction models using the two approaches.

Methods and materials: We analyzed a previous dataset based on a Chinese population sample consisting of 2,092 individuals aged 30-80 years. The prediction models were derived from an exploratory set using ANN and LR analysis, and were tested in the validation set. Performances of these prediction models were then compared.

Results: Univariate analysis indicated that 14 risk factors showed statistically significant association with the prevalence of CA dysfunction (P<0.05). The mean area under the receiver-operating curve was 0.758 (95% CI 0.724-0.793) for LR and 0.762 (95% CI 0.732-0.793) for ANN analysis, but noninferiority result was found (P<0.001). The similar results were found in comparisons of sensitivity, specificity, and predictive values in the prediction models between the LR and ANN analyses.

Conclusion: The prediction models for CA dysfunction were developed using ANN and LR. ANN and LR are two effective tools for developing prediction models based on our dataset.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1. Artificial neural network model showing…
Figure 1. Artificial neural network model showing input variables (nodes), hidden nodes, and connection weights with output node for data on CA dysfunction.
The ANN model including 14 input nodes, 18 hidden nodes and 1 output node. Data from a total of 2077 patients had been used to ANN analysis. BMI- Body mass index, WC-waist circumference, SBP- systolic blood pressure, DBP- diastolic blood pressure, FPG- fasting plasma glucose, PBG- plasma blood glucose, IR-insulin resistance, TG- triglyceride, UA- uric acid, HR-heart rate, PH- Hypertension, DM- Diabetes, PHD- Hypertension duration, DMD- Diabetes duration.

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Source: PubMed

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