Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome
S Fukudo, T Nomura, M Hongo, S Fukudo, T Nomura, M Hongo
Abstract
Background: Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals.
Aims: To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH.
Subjects: Ten IBS patients diagnosed by Rome criteria and 10 healthy controls.
Methods: CRH (2 micrograms/kg) was intravenously administered during duodenal and colonic manometry and plasma adrenocorticotropic hormone (ACTH) was measured by radioimmunoassay.
Results: CRH induced motility of the descending colon in both groups (p < 0.001) and induced greater motility indexes in IBS patients than in controls (p < 0.05). CRH produced duodenal phase III motor activity in 80% of the subjects and duodenal dysmotility in 40% of IBS patients. Abdominal symptoms evoked by CRH in IBS patients lasted significantly longer than those in controls (p < 0.05). CRH induced significant increases in plasma ACTH levels in both groups (p < 0.001) and produced significantly higher plasma ACTH levels in IBS patients than in controls (p < 0.001).
Conclusion: Human intestinal motility is probably modulated by exogenous CRH. The brain-gut in IBS patients may have an exaggerated response to CRH.
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References
- Science. 1981 Sep 18;213(4514):1394-7
- Gastroenterology. 1995 Sep;109(3):671-80
- J Clin Invest. 1985 Nov;76(5):2026-9
- Brain Res. 1986 Jun 4;375(1):117-25
- Gastroenterology. 1986 Oct;91(4):884-9
- Gut. 1987 Jan;28(1):5-12
- Eur J Clin Pharmacol. 1987;31(5):531-4
- Gastroenterology. 1987 Jun;92(6):1885-93
- Tohoku J Exp Med. 1987 Apr;151(4):373-85
- Am J Physiol. 1987 Oct;253(4 Pt 1):G582-6
- Gastroenterology. 1988 Mar;94(3):611-21
- Front Neuroendocrinol. 1995 Oct;16(4):362-82
- Gut. 1995 Nov;37(5):649-53
- Neurogastroenterol Motil. 1996 Mar;8(1):9-18
- Neuroendocrinology. 1996 Apr;63(4):338-48
- Life Sci. 1997;60(11):857-64
- Neuroendocrinology. 1988 Jul;48(1):32-8
- Gastroenterology. 1988 Dec;95(6):1510-7
- Gastroenterology. 1990 Mar;98(3):686-93
- Gastroenterology. 1990 May;98(5 Pt 1):1208-18
- Gastroenterology. 1990 Dec;99(6):1688-704
- J Psychosom Res. 1990;34(5):575-80
- Brain Res Brain Res Rev. 1990 May-Aug;15(2):71-100
- Gastroenterology. 1991 Apr;100(4):964-70
- Pharmacol Rev. 1991 Dec;43(4):425-73
- Neuropsychopharmacology. 1992 Feb;6(2):69-75
- Gastroenterology. 1992 Jul;103(1):12-7
- Neuroendocrinology. 1992 Nov;56(5):611-8
- Gastroenterology. 1993 Mar;104(3):716-23
- Neuroendocrinology. 1993;57(2):346-50
- J Clin Gastroenterol. 1993 Sep;17(2):133-41
- Endocrinology. 1993 Dec;133(6):3058-61
- Ann N Y Acad Sci. 1993 Oct 29;697:233-43
- Neuroendocrinology. 1993 Jul;58(1):57-64
- Endocrinology. 1985 Jul;117(1):23-30
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