A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen, Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen

Abstract

MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and gastric cancer risk. We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR = 0.78, 95% CI = 0.63-0.96, P = 0.021) compared with the wildtype homozygote (NN). The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.

Keywords: MET; gastric cancer; germline variation; susceptibility.

Conflict of interest statement

The authors reported no conflict of interest.

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Source: PubMed

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