Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions
M Haas, B Sis, L C Racusen, K Solez, D Glotz, R B Colvin, M C R Castro, D S R David, E David-Neto, S M Bagnasco, L C Cendales, L D Cornell, A J Demetris, C B Drachenberg, C F Farver, A B Farris 3rd, I W Gibson, E Kraus, H Liapis, A Loupy, V Nickeleit, P Randhawa, E R Rodriguez, D Rush, R N Smith, C D Tan, W D Wallace, M Mengel, Banff meeting report writing committee, Oyedele Adeyi, Venancio Avancini, Serena M Bagnasco, Christopher Bellamy, Gerald Berry, Marie Budev, Patricia Campbell, Maria Cristina R Castro, Linda C Cendales, Juan Pablo Cordoba, Monica Colvin-Adams, Robert B Colvin, Lynn D Cornell, Daisa S R David, Elias David- Neto, Hanneke de Kort, Anthony J Demetris, Cinthia B Drachenberg, A Brad Farris, Carol F Farver, Sandy Feng, Max Fischer, Agnes Fogo, Marcello Franco, Ian W Gibson, Denis Glotz, Martin Goddard, Vijay Gorantla, Annette Gouw, Joseph Grinyó, Mark Haas, Hironori Haga, Luis Hidalgo, Danniele Holanda, Stefan Hubscher, Stanley Jordan, Christina Kaufman, Stuart J Knechtle, Tomasz Kozlowski, Sheri Krams, Edward Kraus, Erik Larsson, Helen Liapis, Maria Gerbase Lima, Alexandre Loupy, John Lunz, Denise Maria Malheiros, Roslyn B Mannon, Michael Mengel, Emmanuel Morelon, Brian Nankivell, Desley Neil, Kenneth Newell, Volker Nickeleit, Irene Noronha, Jon Odorico, Jaqueline O'Leary, John Papadimitriou, Lorraine C Racusen, Parmjeet Randhawa, Erika B Rangel, Nancy Reinsmoen, E Rene Rodriguez, Candice Roufosse, Steven Sacks, Alberto Sánchez-Fueyo, Minnie Sarwal, Janet Scheel, Surya Seshan, Banu Sis, Chandra Smart, Rex Neal Smith, Kim Solez, Carmela D Tan, Helio Tedesco Silva Jr, Dolly B Tyan, Norma Ofelia Uribe, W Dean Wallace, Adriana Zeevi, M Haas, B Sis, L C Racusen, K Solez, D Glotz, R B Colvin, M C R Castro, D S R David, E David-Neto, S M Bagnasco, L C Cendales, L D Cornell, A J Demetris, C B Drachenberg, C F Farver, A B Farris 3rd, I W Gibson, E Kraus, H Liapis, A Loupy, V Nickeleit, P Randhawa, E R Rodriguez, D Rush, R N Smith, C D Tan, W D Wallace, M Mengel, Banff meeting report writing committee, Oyedele Adeyi, Venancio Avancini, Serena M Bagnasco, Christopher Bellamy, Gerald Berry, Marie Budev, Patricia Campbell, Maria Cristina R Castro, Linda C Cendales, Juan Pablo Cordoba, Monica Colvin-Adams, Robert B Colvin, Lynn D Cornell, Daisa S R David, Elias David- Neto, Hanneke de Kort, Anthony J Demetris, Cinthia B Drachenberg, A Brad Farris, Carol F Farver, Sandy Feng, Max Fischer, Agnes Fogo, Marcello Franco, Ian W Gibson, Denis Glotz, Martin Goddard, Vijay Gorantla, Annette Gouw, Joseph Grinyó, Mark Haas, Hironori Haga, Luis Hidalgo, Danniele Holanda, Stefan Hubscher, Stanley Jordan, Christina Kaufman, Stuart J Knechtle, Tomasz Kozlowski, Sheri Krams, Edward Kraus, Erik Larsson, Helen Liapis, Maria Gerbase Lima, Alexandre Loupy, John Lunz, Denise Maria Malheiros, Roslyn B Mannon, Michael Mengel, Emmanuel Morelon, Brian Nankivell, Desley Neil, Kenneth Newell, Volker Nickeleit, Irene Noronha, Jon Odorico, Jaqueline O'Leary, John Papadimitriou, Lorraine C Racusen, Parmjeet Randhawa, Erika B Rangel, Nancy Reinsmoen, E Rene Rodriguez, Candice Roufosse, Steven Sacks, Alberto Sánchez-Fueyo, Minnie Sarwal, Janet Scheel, Surya Seshan, Banu Sis, Chandra Smart, Rex Neal Smith, Kim Solez, Carmela D Tan, Helio Tedesco Silva Jr, Dolly B Tyan, Norma Ofelia Uribe, W Dean Wallace, Adriana Zeevi
Abstract
The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working groups formed at the 2009 and 2011 Banff meetings to: (1) establish consensus criteria for diagnosing antibody-mediated rejection (ABMR) in the presence and absence of detectable C4d deposition; (2) develop consensus definitions and thresholds for glomerulitis (g score) and chronic glomerulopathy (cg score), associated with improved inter-observer agreement and correlation with clinical, molecular and serological data; (3) determine whether isolated lesions of intimal arteritis ("isolated v") represent acute rejection similar to intimal arteritis in the presence of tubulointerstitial inflammation; (4) compare different methodologies for evaluating interstitial fibrosis and for performing/evaluating implantation biopsies of renal allografts with regard to reproducibility and prediction of subsequent graft function; and (5) define clinically and prognostically significant morphologic criteria for subclassifying polyoma virus nephropathy. The key outcome of the 2013 conference is defining criteria for diagnosis of C4d-negative ABMR and respective modification of the Banff classification. In addition, three new Banff Working Groups were initiated.
Keywords: Acute allograft rejection; Banff schema; antibody-mediated rejection; cardiac allograft; chronic allograft rejection; complement C4d; composite tissue allograft; donor-specific antibodies; liver allograft; lung transplantation; pancreas allograft; renal transplantation; transplant biopsy; transplant glomerulopathy; transplant pathology.
© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
Source: PubMed