Initial experience with therapeutic geometric modification of the carotid bulb for true resistant hypertension
Najibullah Habib, Bakhtawar K Mahmoodi, Willem Jan W Bos, Selma C Tromp, Maarten J Suttorp, Mark C Bates, Jan Van der Heyden, Najibullah Habib, Bakhtawar K Mahmoodi, Willem Jan W Bos, Selma C Tromp, Maarten J Suttorp, Mark C Bates, Jan Van der Heyden
Abstract
The contribution of carotid baroreceptor feedback in preventing or potentially contributing to the essential hypertensive cascade is poorly understood. It is clear the carotid sinus nerve action potentials are triggered by carotid bulb stretch rather than pressure and are only sustained during pulsatile increases in pressure. In addition, the carotid baroreceptor negative feedback is gradually extinguished in hypertension patients (a phenomenon known as "resetting"). We report a case of significant reduction in blood pressure in a patient with true resistant hypertension after change in the carotid bulb pulsatile strain patterns following the implant of an intravascular prosthesis.
Trial registration: ClinicalTrials.gov NCT01911897.
Source: PubMed