Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study

Joost W Vanhommerig, Femke A E Lambers, Janke Schinkel, Ronald B Geskus, Joop E Arends, Thijs J W van de Laar, Fanny N Lauw, Kees Brinkman, Luuk Gras, Bart J A Rijnders, Jan T M van der Meer, Maria Prins, MOSAIC (MSM Observational Study of Acute Infection With Hepatitis C) Study Group, J T M van der Meer, R Molenkamp, M Mutschelknauss, H E Nobel, H W Reesink, J Schinkel, M van der Valk, G E L van den Berk, K Brinkman, D Kwa, N van der Meche, A Toonen, D Vos, M van Broekhuizen, F N Lauw, J W Mulder, J E Arends, A van Kessel, I de Kroon, A Boonstra, M E van der Ende, S Hullegie, B J A Rijnders, T J W van de Laar, L Gras, C Smit, F A E Lambers, M Prins, J W Vanhommerig, W van der Veldt, Joost W Vanhommerig, Femke A E Lambers, Janke Schinkel, Ronald B Geskus, Joop E Arends, Thijs J W van de Laar, Fanny N Lauw, Kees Brinkman, Luuk Gras, Bart J A Rijnders, Jan T M van der Meer, Maria Prins, MOSAIC (MSM Observational Study of Acute Infection With Hepatitis C) Study Group, J T M van der Meer, R Molenkamp, M Mutschelknauss, H E Nobel, H W Reesink, J Schinkel, M van der Valk, G E L van den Berk, K Brinkman, D Kwa, N van der Meche, A Toonen, D Vos, M van Broekhuizen, F N Lauw, J W Mulder, J E Arends, A van Kessel, I de Kroon, A Boonstra, M E van der Ende, S Hullegie, B J A Rijnders, T J W van de Laar, L Gras, C Smit, F A E Lambers, M Prins, J W Vanhommerig, W van der Veldt

Abstract

Background. Since 2000, incidence of sexually acquired hepatitis C virus (HCV)-infection has increased among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). To date, few case-control and cohort studies evaluating HCV transmission risk factors were conducted in this population, and most of these studies were initially designed to study HIV-related risk behavior and characteristics. Methods. From 2009 onwards, HIV-infected MSM with acute HCV infection and controls (HIV-monoinfected MSM) were prospectively included in the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study at 5 large HIV outpatient clinics in the Netherlands. Written questionnaires were administered, covering sociodemographics, bloodborne risk factors for HCV infection, sexual behavior, and drug use. Clinical data were acquired through linkage with databases from the Dutch HIV Monitoring Foundation. For this study, determinants of HCV acquisition collected at the inclusion visit were analyzed using logistic regression. Results. Two hundred thirteen HIV-infected MSM (82 MSM with acute HCV infection and 131 MSM without) were included with a median age of 45.7 years (interquartile range [IQR], 41.0-52.2). Receptive unprotected anal intercourse (adjusted odds ratio [aOR], 5.01; 95% confidence interval [CI], 1.63-15.4), sharing sex toys (aOR, 3.62; 95% CI, 1.04-12.5), unprotected fisting (aOR, 2.57; 95% CI, 1.02-6.44), injecting drugs (aOR, 15.62; 95% CI, 1.27-192.6), sharing straws when snorting drugs (aOR, 3.40; 95% CI, 1.39-8.32), lower CD4 cell count (aOR, 1.75 per cubic root; 95% CI, 1.19-2.58), and recent diagnosis of ulcerative sexually transmitted infection (aOR, 4.82; 95% CI, 1.60-14.53) had significant effects on HCV acquisition. Conclusions. In this study, both sexual behavior and biological factors appear to independently increase the risk of HCV acquisition among HIV-infected MSM.

Keywords: HIV-HCV coinfection; MSM; hepatitis C virus; risk factors; sexual transmission.

Figures

Figure 1.
Figure 1.
A, Cleveland dot plot showing results of a multivariable model including variables that potentially have direct effects on acquisition of acute hepatitis C virus (HCV); model 1 of 2. B, Cleveland dot plot showing (1) results of a multivariable model including variables that potentially have direct effects on acquisition of acute HCV and (2) variables that potentially facilitate transmission of acute HCV, model 2 of 2. *, modeled as 2Log(N + 1); **, at the HCV-negative visit preceding study entry, cells/μL. 6M, up to 6 months preceding study entry; NADs, nasally administered drugs; UAI, unprotected anal intercourse; ulcerative STI, any of the following sexually transmitted infections: syphilis, herpes genitalis, lymphogranuloma venereum. Data were collected among 213 human immunodeficiency virus (HIV)-infected men who have sex with men (MSM), 82 of whom had acute HCV infection. All participated in the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study, the Netherlands, 2009–2014.

References

    1. Bradshaw D, Matthews G, Danta M. Sexually transmitted hepatitis C infection: the new epidemic in MSM? Curr Opin Infect Dis 2013; 26:66–72.
    1. van de Laar TJ, Matthews GV, Prins M, Danta M. Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS 2010; 24:1799–812.
    1. van der Helm JJ, Prins M, del Amo J, et al. The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007. AIDS 2011; 25:1083–91.
    1. Yaphe S, Bozinoff N, Kyle R, et al. Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review. Sex Transm Infect 2012; 88:558–64.
    1. van de Laar TJ, Paxton WA, Zorgdrager F, et al. Sexual transmission of hepatitis C virus in human immunodeficiency virus-negative men who have sex with men: a series of case reports. Sex Transm Dis 2011; 38:102–4.
    1. Schmidt AJ, Falcato L, Zahno B, et al. Prevalence of hepatitis C in a Swiss sample of men who have sex with men: whom to screen for HCV infection? BMC Public Health 2014; 14:3.
    1. Urbanus AT, van de Laar TJ, Geskus R, et al. Trends in hepatitis C virus infections among MSM attending a sexually transmitted infection clinic; 1995–2010. AIDS 2014; 28:781–90.
    1. Vanhommerig JW, Stolte IG, Lambers FA, et al. Stabilizing incidence of hepatitis C virus infection among men who have sex with men in Amsterdam. J Acquir Immune Defic Syndr 2014; 66:e111–5.
    1. Jin F, Prestage GP, Matthews G, et al. Prevalence, incidence and risk factors for hepatitis C in homosexual men: data from two cohorts of HIV-negative and HIV-positive men in Sydney, Australia. Sex Transm Infect 2010; 86:25–8.
    1. Danta M, Brown D, Bhagani S, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 2007; 21:983–91.
    1. Schmidt AJ, Rockstroh JK, Vogel M, et al. Trouble with bleeding: risk factors for acute hepatitis C among HIV-positive gay men from Germany--a case-control study. PLoS One 2011; 6:e17781.
    1. Centers for Disease Control and Prevention (CDC). Sexual transmission of hepatitis C virus among HIV-infected men who have sex with men--New York City, 2005–2010. MMWR Morb Mortal Wkly Rep 2011; 60:945–50.
    1. Witt MD, Seaberg EC, Darilay A, et al. Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984–2011. Clin Infect Dis 2013; 57:77–84.
    1. Wandeler G, Gsponer T, Bregenzer A, et al. Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly evolving epidemic. Clin Infect Dis 2012; 55:1408–16.
    1. Nishijima T, Shimbo T, Komatsu H, et al. Incidence and risk factors for incident hepatitis C infection among men who have sex with men with HIV-1 infection in a large urban HIV clinic in Tokyo. J Acquir Immune Defic Syndr 2014; 65:213–7.
    1. Sanchez C, Plaza Z, Vispo E, et al. Scaling up epidemics of acute hepatitis C and syphilis in HIV-infected men who have sex with men in Spain. Liver Int 2013; 33:1357–62.
    1. Urbanus AT, van de Laar TJ, Stolte IG, et al. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009; 23:F1–7.
    1. Matthews GV, Pham ST, Hellard M, et al. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis 2011; 52:803–11.
    1. Gambotti L, Batisse D, Colin-de-Verdiere N, et al. Acute hepatitis C infection in HIV positive men who have sex with men in Paris, France, 2001–2004. Euro Surveill 2005; 10:115–7.
    1. Serpaggi J, Chaix ML, Batisse D, et al. Sexually transmitted acute infection with a clustered genotype 4 hepatitis C virus in HIV-1-infected men and inefficacy of early antiviral therapy. AIDS 2006; 20:233–40.
    1. Montoya-Ferrer A, Fierer DS, Alvarez-Alvarez B, et al. Acute hepatitis C outbreak among HIV-infected men, Madrid, Spain. Emerg Infect Dis 2011; 17:1560–2.
    1. Lambers FA, Brinkman K, Schinkel J, et al. Treatment of acute hepatitis C virus infection in HIV-infected MSM: the effect of treatment duration. AIDS 2011; 25:1333–6.
    1. Firth D. Bias reduction of maximum likelihood estimates. Biometrika; 1993; 80:27–38.
    1. Garg S, Taylor LE, Grasso C, Mayer KH. Prevalent and incident hepatitis C virus infection among HIV-infected men who have sex with men engaged in primary care in a Boston community health center. Clin Infect Dis 2013; 56:1480–7.
    1. Rauch A, Rickenbach M, Weber R, et al. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 2005; 41:395–402.
    1. Jarzebowski W, Caumes E, Dupin N, et al. Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med 2012; 172:1237–43.
    1. Owen G. An ‘elephant in the room’? Stigma and hepatitis C transmission among HIV-positive ‘serosorting’ gay men. Cult Health Sex 2008; 10:601–10.
    1. Martin TC, Martin NK, Hickman M, et al. HCV reinfection incidence and treatment outcome among HIV-positive MSM. AIDS 2013; 27:2551–7.
    1. Markov PV, van de Laar TJ, Thomas XV, et al. Colonial history and contemporary transmission shape the genetic diversity of hepatitis C virus genotype 2 in Amsterdam. J Virol 2012; 86:7677–87.
    1. Kirby T, Thornber-Dunwell M. High-risk drug practices tighten grip on London gay scene. Lancet 2013; 381:101–2.
    1. Aaron S, McMahon JM, Milano D, et al. Intranasal transmission of hepatitis C virus: virological and clinical evidence. Clin Infect Dis 2008; 47:931–4.
    1. Scheinmann R, Hagan H, Lelutiu-Weinberger C, et al. Non-injection drug use and Hepatitis C Virus: a systematic review. Drug Alcohol Depend 2007; 89:1–12.
    1. McFaul K, Maghlaoui A, Nzuruba M, et al. Acute hepatitis C infection in HIV-negative men who have sex with men. J Viral Hepat 2015; 22:535–8.

Source: PubMed

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