Effects of comorbid conditions on health-related quality of life in youth with Type 2 diabetes: the TODAY clinical trial
Mary E Larkin, Natalie Walders-Abramson, Kathryn Hirst, Joyce Keady, Carolyn E Ievers-Landis, Elizabeth M Venditti, Patrice M Yasuda, Mary E Larkin, Natalie Walders-Abramson, Kathryn Hirst, Joyce Keady, Carolyn E Ievers-Landis, Elizabeth M Venditti, Patrice M Yasuda
Abstract
Aim: To explore associations between health-related quality of life (HRQOL) and comorbidities in youth with Type 2 diabetes.
Patients & methods: Of 699 youth in the TODAY study, 685 (98%) had baseline HRQOL data, 649 (93%) at 6 months and 583 (83%) at 24 months. Comorbidities were defined by sustained abnormal values and treatment regimens.
Results: At baseline, 22.2% of participants demonstrated impaired HRQOL. Only depressive symptoms distinguished those with versus without impaired HRQOL and were significantly related to later impaired HRQOL (p < 0.0001). A significant correspondence between impaired HRQOL and number of comorbidities (p = 0.0003) was noted, but was driven by the presence of depressive symptoms.
Conclusion: Results emphasize the need for evaluation of depressive symptoms. Other comorbidities did not have a significant impact on HRQOL in this cohort.
Keywords: health-related quality of life; hyperlipidemia; hypertension; microalbuminuria; pediatric Type 2 diabetes.
Figures
![Figure 1. Distribution of impaired HRQOL by…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4820314/bin/nihms-741994-f0001.jpg)
![Figure 2. Percent impaired HRQOL by presence…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4820314/bin/nihms-741994-f0002.jpg)
![Figure 3. Percentage impaired HRQOL by presence…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4820314/bin/nihms-741994-f0003.jpg)
Source: PubMed