Predictive parameters of arteriovenous fistula functional maturation in a population of patients with end-stage renal disease

Khalid Bashar, Adeel Zafar, Sawsan Elsheikh, Donagh A Healy, Mary Clarke-Moloney, Liam Casserly, Paul E Burke, Eamon G Kavanagh, Stewart R Walsh, Khalid Bashar, Adeel Zafar, Sawsan Elsheikh, Donagh A Healy, Mary Clarke-Moloney, Liam Casserly, Paul E Burke, Eamon G Kavanagh, Stewart R Walsh

Abstract

Introduction: With increasing numbers of patients diagnosed with ESRD, arteriovenous fistula (AVF) maturation has become a major factor in improving both dialysis related outcomes and quality of life of those patients. Compared to other types of access it has been established that a functional AVF access is the least likely to be associated with thrombosis, infection, hospital admissions, secondary interventions to maintain patency and death.

Aim: Study of demographic factors implicated in the functional maturation of arteriovenous fistulas. Also, to explore any possible association between preoperative haematological investigations and functional maturation.

Methods: We performed a retrospective chart review of all patients with ESRD who were referred to the vascular service in the University Hospital of Limerick for creation of vascular access for HD. We included patients with primary AVFs; and excluded those who underwent secondary procedures.

Results: Overall AVF functional maturation rate in our study was 53.7% (52/97). Female gender showed significant association with nonmaturation (P = 0.004) and was the only predictor for non-maturation in a logistic regression model (P = 0.011). Patients who had history of renal transplant (P = 0.036), had relatively lower haemoglobin levels (P = 0.01) and were on calcium channel blockers (P = 0.001) showed better functional maturation rates.

Conclusion: Female gender was found to be associated with functional non-maturation, while a history kidney transplant, calcium channel-blocker agents and low haemoglobin levels were all associated with successful functional maturation. In view of the conflicting evidence in the literature, large prospective multi-centre registry-based studies with well-defined outcomes are needed.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. Age distribution among male patients.
Fig 1. Age distribution among male patients.
Fig 2. Age distribution among female patients.
Fig 2. Age distribution among female patients.
Fig 3. Variation in age between males…
Fig 3. Variation in age between males and females groups.
Fig 4. Variation in age between mature…
Fig 4. Variation in age between mature and non-mature AVF groups.
Fig 5. Variation in haemoglobin count between…
Fig 5. Variation in haemoglobin count between mature and non-mature AVF groups.

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