Stress, inflammation, and yoga practice

Abstract

Objective: To address the mechanisms underlying hatha yoga's potential stress-reduction benefits, we compared inflammatory and endocrine responses of novice and expert yoga practitioners before, during, and after a restorative hatha yoga session, as well as in two control conditions. Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual's physiological recovery.

Methods: A total of 50 healthy women (mean age, 41.32 years; range, 30-65 years), 25 novices and 25 experts, were exposed to each of the conditions (yoga, movement control, and passive-video control) during three separate visits.

Results: The yoga session boosted participants' positive affect compared with the control conditions, but no overall differences in inflammatory or endocrine responses were unique to the yoga session. Importantly, even though novices and experts did not differ on key dimensions, including age, abdominal adiposity, and cardiorespiratory fitness, novices' serum interleukin (IL)-6 levels were 41% higher than those of experts across sessions, and the odds of a novice having detectable C-reactive protein (CRP) were 4.75 times as high as that of an expert. Differences in stress responses between experts and novices provided one plausible mechanism for their divergent serum IL-6 data; experts produced less lipopolysaccharide-stimulated IL-6 in response to the stressor than novices, and IL-6 promotes CRP production.

Conclusion: The ability to minimize inflammatory responses to stressful encounters influences the burden that stressors place on an individual. If yoga dampens or limits stress-related changes, then regular practice could have substantial health benefits.

Figures

Figure 1

Timeline for experimental participation during each of the three CRC sessions.

Figure 2

Mean (± SEM) changes in self-reported positive affect on the PANAS as a function of time and condition. Experts and novices did not differ.

Figure 3

Mean (± SEM) heart rate throughout the admissions as a function of novice vs. expert yoga practitioner status. * denotes P = .03.

Figure 4

Mean (± SEM) serum IL-6 as a function of novice vs. expert yoga practitioner status also reflect significantly elevated levels of IL-6 post-intervention.

Figure 5

Mean (± SEM) LPS-stimulated IL-6 production throughout the admissions as a function of novice vs. expert yoga practitioner status. * denotes P = .05.

Figure 6

The numbers of novices and experts falling into low, medium, or high inflammatory groups based on the number of assays on which they were above the baseline median values for serum Il-6, TNF-α, sIL-6r, and hsCRP, and LPS-stimulated IL-6 and TNF-α production.