Allogeneic cell therapy: a new paradigm in therapeutics

Vasileios Karantalis, Ivonne Hernandez Schulman, Wayne Balkan, Joshua M Hare, Vasileios Karantalis, Ivonne Hernandez Schulman, Wayne Balkan, Joshua M Hare

No abstract available

Keywords: Editorials; allogeneic transplantation; autologous transplants; meta-analysis; stem cells.

Figures

Figure 1

Mesenchymal stem cells are considered immunoprivileged due to their lack of expression of Major Histocompatibility Class II proteins and costimulatory molecules B7 and CD40 ligand and exert immunosuppressive actions through inhibition of innate and adaptive immunity.

Figure 2. Comparison of Autologous and Allogeneic stem cell therapy

Allogeneic stem cell therapy offers advantages over the autologous counterpart. The stem cells are derived from young healthy donors, eliminating any co-morbidities associated with disease states. Allogeneic cells grown and kept in stem cell banks so that they are available for immediate delivery.