Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome
Bianca M M Streng, Marin Bont, Eveline M Delemarre, Rob S Binnendijk, Gaby Smit, Gerco den Hartog, Antonia M W Coppus, Esther de Vries, Michel E Weijerman, Regina Lamberts, Gert de Graaf, Fiona R van der Klis, Gestur Vidarsson, Neele Rave, Louis J Bont, Joanne G Wildenbeest, Bianca M M Streng, Marin Bont, Eveline M Delemarre, Rob S Binnendijk, Gaby Smit, Gerco den Hartog, Antonia M W Coppus, Esther de Vries, Michel E Weijerman, Regina Lamberts, Gert de Graaf, Fiona R van der Klis, Gestur Vidarsson, Neele Rave, Louis J Bont, Joanne G Wildenbeest
Abstract
The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.
Clinical trials registration: NCT05145348.
Keywords: COVID-19 vaccination; Down syndrome; SARS-CoV-2; antibody response.
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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Source: PubMed