Improving ethical review of research involving incentives for health promotion

Alex John London, David A Borasky Jr, Anant Bhan, Ethics Working Group of the HIV Prevention Trials Network, Alex John London, David A Borasky Jr, Anant Bhan, Ethics Working Group of the HIV Prevention Trials Network

Abstract

Alex London and colleagues propose new ethical frameworks for evaluating the risks associated with research in which financial or other incentives are used to promote healthy behavior.

Conflict of interest statement

AJL, DAB, and AB are members of the Ethics Working Group of the HIV Prevention Trials Network, which currently sponsors two clinical trials involving financial incentives for health.

References

    1. Fiszbein A, Schady N. Conditional cash transfers: reducing present and future poverty. Washington (District of Columbia): The World Bank; 2009.
    1. Lagarde M, Haines A, Palmer N. Conditional cash transfers for improving uptake of health interventions in low- and middle-income countries: a systematic review. JAMA. 2007;298:1900–1910.
    1. Lussier JP, Heil SH, Mongeon JA, Badger GJ, Higgins ST. A meta-analysis of voucher-based reinforcement therapy for substance use disorders. Addiction. 2006;101:192–203.
    1. Giuffrida A, Torgerson DJ. Should we pay the patient? Review of financial incentives to enhance patient compliance. BMJ. 1997;315:703–707.
    1. Paul-Ebhohimhen V, Avenell A. Systematic review of the use of financial incentives in treatments for obesity and overweight. Obes Rev. 2008;9:355–367.
    1. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont report. Washington (District of Columbia): US Government Printing Office; 1979.
    1. 59th WMA General Assembly. WMA Declaration of Helsinki: ethical principles for medical research involving human subjects. Ferney-Voltaire (France): World Medical Association; 2008.
    1. Council for International Organizations of Medical Sciences, World Health Organization. International ethical guidelines for biomedical research involving human subjects. Geneva: Council for International Organizations of Medical Sciences; 2002.
    1. US Department of Health and Human Services, National Institutes of Health, Office for Human Research Protections. The common rule, Title 45 (public welfare), Code of Federal Regulations, Part 46 (protection of human subjects). 2005. Available: . Accessed 14 February 2012.
    1. Ackerman T. An ethical framework for the practice of paying research subjects. IRB. 1989;11:1–4.
    1. Dickert N, Grady C. What's the price of a research subject? Approaches to payment for research participation. N Engl J Med. 1999;341:198–203.
    1. Dickert N, Emanuel E, Grady C. Paying research subjects: an analysis of current policies. Ann Intern Med. 2002;136:368–373.
    1. Halpern SD, Raz A, Kohn R, Rey M, Asch DA, et al. Regulated payments for living kidney donation: an empirical assessment of the ethical concerns. Ann Intern Med. 2010;152:358–365.
    1. Cryder CE, John London A, Volpp KG, Loewenstein G. Informative inducement: study payment as a signal of risk. Soc Sci Med. 2010;70:455–464.
    1. Singer E, Couper MP. Do incentives exert undue influence on survey participation? Experimental evidence. J Empir Res Hum Res Ethics. 2008;3:49–56.
    1. Anderson EE, DuBois JM. The need for evidence-based research ethics: a review of the substance abuse literature. Drug Alcohol Depend. 2007;86:95–105.
    1. Bentley JP, Thacker PG. The influence of risk and monetary payment on the research participation decision making process. J Med Ethics. 2004;30:293–298.
    1. Halpern SD, Karlawish JH, Casarett D, Berlin JA, Asch DA. Empirical assessment of whether moderate payments are undue or unjust inducements for participation in clinical trials. Arch Intern Med. 2004;164:801–803.
    1. Grant RW, Sugarman J. Ethics in human subjects research: do incentives matter? J Med Philos. 2004;29:717–738.
    1. London AJ. Undue inducements and reasonable risks: will the dismal science lead to dismal research ethics? Am J Bioeth. 2005;5:29–32.
    1. Volpp KG, John LK, Troxel AB, Norton L, Fassbender J, et al. Financial incentive-based approaches for weight loss: a randomized trial. JAMA. 2008;300:2631–2637.
    1. Volpp KG, Troxel AB, Pauly MV, Glick HA, Puig A, et al. A randomized, controlled trial of financial incentives for smoking cessation. N Engl J Med. 2009;360:699–709.
    1. Marteau TM, Ashcroft RE, Oliver A. Using financial incentives to achieve healthy behavior. BMJ. 2009;338:b1415. doi: .
    1. Filmer D, Schady N. Are there diminishing returns to transfer size in conditional cash transfers? Policy Research Working Paper Series 4999. Washington (District of Columbia): The World Bank; 2009.
    1. Emanuel EJ. Undue inducement: nonsense on stilts? Am J Bioeth. 2005;5:9–13.
    1. Macklin R. “Due” and “undue” inducements: on paying money to research subjects. IRB. 1981;3:1–6.
    1. Awofeso N. Anti-tuberculosis medication side-effects constitute major factor for poor adherence to tuberculosis treatment. Bull World Health Organ. 2008;86:B–D.
    1. Weijer C. Thinking clearly about research risk: implications of the work of Benjamin Freedman. IRB. 1999;21:1–5.
    1. London AJ, Kimmelman J, Emborg ME. Research ethics. Beyond access vs. protection in trials of innovative therapies. Science. 2010;328:829–830.
    1. Deci EL, Koestner R, Ryan RM. A meta-analytic review of experiments examining the effects of extrinsic rewards on intrinsic motivation. Psychol Bull. 1999;125:627–668.
    1. Frey BS, Jegen R. Motivation crowding theory. J Econ Surv. 2001;15:589–611.
    1. Bowles S. Policies designed for self-interested citizens may undermine “the moral sentiments”: evidence from economic experiments. Science. 2008;320:1605–1609.
    1. London AJ. Justice and the human development approach to international research. Hastings Cent Rep. 2005;35:24–37.
    1. Murayama K, Matsumoto M, Izuma K, Matsumoto K. Neural basis of the undermining effect of monetary reward on intrinsic motivation. Proc Natl Acad Sci U S A. 2010;107:20911–20916.
    1. Camerer CF. Removing financial incentives demotivates the brain. Proc Natl Acad Sci U S A. 2010;107:20849–20850.

Source: PubMed

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