Relationship between HbA1c and continuous glucose monitoring in Chinese population: a multicenter study

Jian Zhou, Yifei Mo, Hong Li, Xingwu Ran, Wenying Yang, Qiang Li, Yongde Peng, Yanbing Li, Xin Gao, Xiaojun Luan, Weiqing Wang, Yun Xie, Weiping Jia, Jian Zhou, Yifei Mo, Hong Li, Xingwu Ran, Wenying Yang, Qiang Li, Yongde Peng, Yanbing Li, Xin Gao, Xiaojun Luan, Weiqing Wang, Yun Xie, Weiping Jia

Abstract

Objective: Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status.

Methods: Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban areas across China from 2007-2009 and data of 673 subjects were included into the final analysis. Oral glucose tolerance test (OGTT) classified the participants as nondiabetic subjects, including those with normal glucose regulation (NGR; n = 121) and impaired glucose regulation (IGR; n = 209), or newly diagnosed type 2 diabetes (n = 343). All participants completed testing for HbA1c levels and wore a CGM system for three consecutive days. The 24 h MBG levels were calculated. Spearman correlations and linear regression analyses were applied to quantify the relationship between glucose markers.

Results: The levels of HbA1c and 24 h MBG significantly increased with presence of glucose intolerance (NGR<IGR<type 2 diabetes; both, P<0.001). Analysis of the total population indicated that HbA1c was strongly correlated with 24 h MBG (r = 0.735). The correlation was also found to be significant for the subgroup of participants with newly diagnosed type 2 diabetes (r = 0.694, P<0.001). Linear regression analysis of the total study population yielded the following equation: 24 h MBG(mmol/L )= 1.198×HbA1c-0.582 (24 h MBG(mg/dL )= 21.564×HbA1c-10.476) (R(2)= 0.670, P<0.001). The model fit was not improved by application of exponential or quadratic modeling. When HbA1c was 6.5%, the calculated 24 h MBG was 7.2 (6.4-8.1) mmol/L (130 (115-146) mg/dL); and when HbA1c was 7.0%, the 24 h MBG was 7.8 (6.9-8.7) mmol/L (140 (124-157) mg/dL).

Conclusions: Our study provided the reference data of the relationship between HbA1c and CGM in Chinese subjects.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1. Correlation analysis of 24( n…
Figure 1. Correlation analysis of 24(n = 673).
A significant positive correlation exists between the 24(r = 0.735, P<0.001).

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Source: PubMed

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