Efficiency and safety of tranexamic acid in reducing blood loss in total shoulder arthroplasty: A systematic review and meta-analysis

Chuan-Xiu Sun, Lu Zhang, Li-Dong Mi, Guang-Yu Du, Xue-Gang Sun, Sheng-Wei He, Chuan-Xiu Sun, Lu Zhang, Li-Dong Mi, Guang-Yu Du, Xue-Gang Sun, Sheng-Wei He

Abstract

Objective: This meta-analysis aimed to evaluate the efficiency and safety of tranexamic acid for reducing blood loss and transfusion requirements in patients undergoing total shoulder arthroplasty.

Methods: A systematic search was performed in Embase (1980-2017.04, embase.com), Medline (1966-2017.04, medline.com), PubMed (1966-2017.04, pubmed.com), ScienceDirect (1985-2017.04, sciencedirect.com), and Web of Science (1950-2017.04, webofknowledge.com). Study which assessed the efficiency and safety of tranexamic acid in total shoulder arthroplasty was selected. Meta-analysis was performed using Stata 11.0 software.

Results: In all, 484 patients from 2 randomized controlled trials (RCTs) and 2 non-RCTs were subjected to meta-analysis. The present meta-analysis demonstrated that there was less total blood loss (mean difference [MD] -172.16, 95% confidence interval [CI] -35.46 to -308.87, P = .01, d = 0.33) and transfusion rate (odds ratio 0.34, 95% CI 0.13 to 0.91, P = .03, d = 0.29) in tranexamic acid groups compared with the control groups. There were no significant differences in duration of surgery (MD 0.02, 95% CI -0.12 to 0.22, P = .89, d = 0.19), length of stay (MD -0.06, 95% CI -0.26 to 0.14, P = .56, d = 0.20), or incidence of adverse effects such as deep venous thrombosis (odds ratio 1.15, 95% CI 0.33 to 4.00, P = .83, d = 0.53).

Conclusion: Clinical application of tranexamic acid seemed to result in significant reductions in total blood loss, hemoglobin decline and transfusion requirements following total shoulder arthroplasty. Moreover, no increased risk of the thrombotic events was identified. Due to the limited quality of the evidence currently available, higher quality RCTs are required.

Conflict of interest statement

Conflicts of interest: The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Search results and the selection procedure.
Figure 2
Figure 2
Forest plot diagram showing effect of tranexamic acid on total blood loss.
Figure 3
Figure 3
Forest plot diagram showing effect of tranexamic acid on hemoglobin level.
Figure 4
Figure 4
Forest plot diagram showing effect of tranexamic acid on transfusion rate.
Figure 5
Figure 5
Forest plot diagram showing effect of tranexamic acid on duration of surgery.
Figure 6
Figure 6
Forest plot diagram showing effect of tranexamic acid on the length of hospital stay.
Figure 7
Figure 7
Forest plot diagram showing effect of tranexamic acid on the risk of DVT.
Figure 8
Figure 8
Plots of Begg test and Egger test for publication bias of transfusion rate.

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Source: PubMed

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