Surface respiratory electromyography and dyspnea in acute heart failure patients

Abstract

Introduction and objectives: Dyspnea is the most common symptom among hospitalized patients with heart failure (HF) but besides dyspnea questionnaires (which reflect the subjective patient sensation and are not fully validated in HF) there are no measurable physiological variables providing objective assessment of dyspnea in a setting of acute HF patients. Studies performed in respiratory patients suggest that the measurement of electromyographic (EMG) activity of the respiratory muscles with surface electrodes correlates well with dyspnea. Our aim was to test the hypothesis that respiratory muscles EMG activity is a potential marker of dyspnea severity in acute HF patients.

Methods: Prospective and descriptive pilot study carried out in 25 adult patients admitted for acute HF. Measurements were carried out with a cardio-respiratory portable polygraph including EMG surface electrodes for measuring the activity of main (diaphragm) and accessory (scalene and pectoralis minor) respiratory muscles. Dyspnea sensation was assessed by means of the Likert 5 questionnaire. Data were recorded during 3 min of spontaneous breathing and after breathing at maximum effort for several cycles for normalizing data. An index to quantify the activity of each respiratory muscle was computed. This assessment was carried out within the first 24 h of admission, and at day 2 and 5.

Results: Dyspnea score decreased along the three measured days. Diaphragm and scalene EMG index showed a positive and significant direct relationship with dyspnea score (p<0.001 and p = 0.003 respectively) whereas pectoralis minor muscle did not.

Conclusion: In our pilot study, diaphragm and scalene EMG activity was associated with increasing severity of dyspnea. Surface respiratory EMG could be a useful objective tool to improve assessment of dyspnea in acute HF patients.

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Jordi Rigau is employed by Sibel S.A.U. Additionally, Sibel S.A.U. kindly lent the cardio-respiratory polygraph for the study. This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

Figures

Fig 1. Diagram of the measurement setting in heart failure patients.

Noninvasive electromyography (EMG) of respiratory muscles was assessed by surface electrodes. EMG signals and breathing flow indirectly sensed by a nasal cannula were recorded by a portable respiratory polygraph for subsequent data processing.

Fig 2. Example of the EMG signals from the polygraph recorder during a normalizing breathing maneuver.

Breathing flow and EMG of diaphragm, scalene and pectoralis minor. All these signals are measured in Volts in arbitrary scale since they correspond to an uncalibrated flow signal sensed by nasal prongs and to the muscle activity EMG signals with an amplitude that depends on the amplifier gain. The first cycles correspond to spontaneous breathing and the last ones (starting at time 10 s approx.) correspond to maximum effort breathing. Increase in flow amplitude was associated with augmented respiratory muscles activity.

Fig 3. Diaphragm and scalene EMG activity index as a function of dyspnea (Likert 5 scale).

EMG indices increased with dyspnea severity. Data are EMG index for measurements (all patients, all days) with a given dyspnea index value. Data are mean ± SE. See text for more details.