SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020

Nadia Oreshkova, Robert Jan Molenaar, Sandra Vreman, Frank Harders, Bas B Oude Munnink, Renate W Hakze-van der Honing, Nora Gerhards, Paulien Tolsma, Ruth Bouwstra, Reina S Sikkema, Mirriam Gj Tacken, Myrna Mt de Rooij, Eefke Weesendorp, Marc Y Engelsma, Christianne Jm Bruschke, Lidwien Am Smit, Marion Koopmans, Wim Hm van der Poel, Arjan Stegeman, Nadia Oreshkova, Robert Jan Molenaar, Sandra Vreman, Frank Harders, Bas B Oude Munnink, Renate W Hakze-van der Honing, Nora Gerhards, Paulien Tolsma, Ruth Bouwstra, Reina S Sikkema, Mirriam Gj Tacken, Myrna Mt de Rooij, Eefke Weesendorp, Marc Y Engelsma, Christianne Jm Bruschke, Lidwien Am Smit, Marion Koopmans, Wim Hm van der Poel, Arjan Stegeman

Abstract

Respiratory disease and increased mortality occurred in minks on two farms in the Netherlands, with interstitial pneumonia and SARS-CoV-2 RNA in organ and swab samples. On both farms, at least one worker had coronavirus disease-associated symptoms before the outbreak. Variations in mink-derived viral genomes showed between-mink transmission and no infection link between the farms. Inhalable dust contained viral RNA, indicating possible exposure of workers. One worker is assumed to have attracted the virus from mink.

Keywords: SARS-CoV-2; interstitial pneumonia; mink; transmission.

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Schematic representation of the time-line of events in the first month of a SARS-CoV-2 outbreak on two mink farms, the Netherlands, April 2020
Figure 2
Figure 2
Lung from a necropsied mink, SARS-CoV-2 outbreak on two mink farms, the Netherlands, April 2020
Figure 3
Figure 3
Maximum likelihood phylogenetic tree of SARS-CoV-2 sequences from minks and selected full-length sequences from the GISAID EpiCoV database

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Source: PubMed

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