The Efficacy of Metacognitive Therapy: A Systematic Review and Meta-Analysis

Nicoline Normann, Nexhmedin Morina, Nicoline Normann, Nexhmedin Morina

Abstract

Background: Metacognitive therapy (MCT) continues to gain increased ground as a treatment for psychological complaints. During the last years, several clinical trials on the efficacy of MCT have been published. The aim of the current study was to provide an updated meta-analytic review of the effect of MCT for psychological complaints. Methods: We conducted a systematic search of trials on MCT for young and adult patients with psychological complaints published until January 2018, using PsycINFO, PubMed, the Cochrane Library, and Google Scholar. Trials with a minimum of 10 participants in the MCT condition were included. Results: A total of 25 studies that examined a variety of psychological complaints met our inclusion criteria, of which 15 were randomized controlled trials. We identified only one trial that was conducted with children and adolescents. In trials with adult patients, large uncontrolled effect size estimates from pre- to post-treatment and follow-up suggest that MCT is effective at reducing symptoms of the targeted primary complaints, anxiety, depression, and dysfunctional metacognitions. The comparison with waitlist control conditions also resulted in a large effect (Hedges' g = 2.06). The comparison of MCT to cognitive and behavioral interventions at post-treatment and at follow-up showed pooled effect sizes (Hedges' g) of 0.69 and 0.37 at post-treatment (k = 8) and follow-up (k = 7), respectively. Conclusions: Our findings indicate that MCT is an effective treatment for a range of psychological complaints. To date, strongest evidence exists for anxiety and depression. Current results suggest that MCT may be superior to other psychotherapies, including cognitive behavioral interventions. However, more trials with larger number of participants are needed in order to draw firm conclusions.

Keywords: anxiety; depression; mental disorders; meta-analysis; metacognitive therapy; psychopathology; psychotherapy.

Figures

Figure 1
Figure 1
Flow diagram of study selection process.
Figure 2
Figure 2
Forest plot of within-group effect size estimates for the efficacy of MCT on primary outcome measures from pre- to post-treatment. BDD, body dysmorphic disorder; GAD, generalized anxiety disorder; OCD, obsessive-compulsive disorder; PTSD, post-traumatic stress disorder.
Figure 3
Figure 3
(A) Pre- to post-treatment effect sizes and forest plots for MCT compared to waitlist control conditions. (B) Pre- to post-treatment effect sizes and forest plots for MCT compared to active control conditions.

References

    1. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th Edn., DSM-IV-TR). Washington, DC: American Psychiatric Association.
    1. Beck A. T., Epstein N., Brown G., Steer R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. J. Consult. Clin. Psychol. 56, 893. 10.1037/0022-006x.56.6.893
    1. Beck A. T., Steer R. A., Brown G. K. (1996). Beck Depression Inventory-II. San Antonio, TX: The Psychological Corporation.
    1. Beck A. T., Ward C. H., Mendelson M., Mock J., Erbaugh J. (1961). An inventory for measuring depression. Arch. Gen. Psychiatry 4, 561–571. 10.1001/archpsyc.1961.01710120031004
    1. Borenstein M., Hedges L. V., Higgins J. P. T., Rothstein H. R. (2009). Introduction to Meta-Analysis. Chichester: John Wiley and Sons.
    1. *. Capobianco L., Reeves D., Morrison A. P., Wells A. (2018). Group Metacognitive Therapy vs. mindfulness meditation therapy in a transdiagnostic patient sample: a randomised feasibility trial. Psychiatry Res. 259, 554–561. 10.1016/j.psychres.2017.11.045
    1. Cartwright-Hatton S., Wells A. (1997). Beliefs about worry and intrusions: the meta-cognitions questionnaire and its correlates. J. Anxiety Disord. 11, 279–296. 10.1016/s0887-6185(97)00011-x
    1. Cohen J. (1988). Statistical Power Analysis for the Behavioral Sciences, 2nd Edn. New York, NY: Routledge.
    1. *. Dammen T., Papageorgiou C., Wells A. (2015). An open trial of group metacognitive therapy for depression in Norway. Nord. J. Psychiatry 69, 126–131. 10.3109/08039488.2014.936502
    1. *. Dammen T., Papageorgiou C., Wells A. (2016). A two year follow up study of group metacognitive therapy for depression in Norway. J. Depress. Anxiety 5:227 10.4172/2167-1044.1000227
    1. Duval S., Tweedie R. (2000). Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56, 455–463. 10.1111/j.0006-341x.2000.00455.x
    1. Esbjørn B. H., Normann N., Christiansen B. M., Reinholdt-Dunne M. L. (2018). The efficacy of group metacognitive therapy for children (MCT-c) with generalized anxiety disorder: an open trial. J. Anxiety Disord. 53, 16–21. 10.1016/j.janxdis.2017.11.002
    1. *. Fisher P. L., McNicol K., Young B., Smith E., Salmon P. (2015). Alleviating emotional distress in adolescent and young adult cancer survivors: an open trial of metacognitive therapy. J. Adolesc. Young Adult Oncol. 4, 64–69. 10.1089/jayao.2014.0046
    1. Fu R., Gartlehner G., Grant M., Shamliyan T., Sedrakyan A., Wilt T. J., Trikalinos T. A. (2011). Conducting quantitative synthesis when comparing medical interventions: AHRQ and the effective health care program. J. Clin. Epidemiol. 64, 1187–1197. 10.1016/j.jclinepi.2010.08.010
    1. *. Hagen R., Hjemdal O., Solem S., Kennair L. E. O., Nordahl H. M., Fisher P., et al. . (2017). Metacognitive therapy for depression in adults: a waiting list randomized controlled trial with six months follow-up. Front. Psychol. 8:31. 10.3389/fpsyg.2017.00031
    1. Higgins J. P., Altman D. G., Gøtzsche P. C., Jüni P., Moher D., Oxman A. D., Sterne J. A. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343:d5928. 10.1136/bmj.d5928
    1. Higgins J. P., Thompson S. G., Deeks J. J., Altman D. G. (2003). Measuring inconsistency in meta-analyses. BMJ 327:557. 10.1136/bmj.327.7414.557
    1. *. Hjemdal O., Hagen R., Solem S., Nordahl H., Kennair L. E. O., Ryum T., Nordahl H. M., Wells A. (2017). Metacognitive therapy in major depression: an open trial of comorbid cases. Cogn. Behav. Pract. 24, 312–318. 10.1016/j.cbpra.2016.06.006
    1. *. Johnson S. U., Hoffart A., Nordahl H. M., Wampold B. (2017). Metacognitive therapy versus disorder-specific CBT for comorbid anxiety disorders: a randomized controlled trial. J. Anxiety Disord. 50, 103–112. 10.1016/j.janxdis.2017.06.004
    1. *. Jordan J., Carter J. D., McIntosh V. V., Fernando K., Frampton C. M., Porter R. J., Joyce P. R. (2014). Metacognitive therapy versus cognitive behavioural therapy for depression: a randomized pilot study. Aust. N. Z. J. Psychiatry 48, 932–943. 10.1177/0004867414533015
    1. Moher D., Liberati A., Tetzlaff J., Altman D. G., The PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6:e1000097 10.1371/journal.pmed.1000097
    1. Morris S. B., DeShon R. P. (2002). Combining effect size estimates in meta-analysis with repeated measures and independent-groups designs. Psychol. Methods 7:105. 10.1037//1082-989x.7.1.105
    1. *. Morrison A. P., Pyle M., Chapman N., French P., Parker S. K., Wells A. (2014). Metacognitive therapy in people with a schizophrenia spectrum diagnosis and medication resistant symptoms: a feasibility study. J. Behav. Ther. Exp. Psychiatry 45, 280–284. 10.1016/j.jbtep.2013.11.003
    1. *. Nordahl H. M. (2009). Effectiveness of brief metacognitive therapy versus cognitive-behavioral therapy in a general outpatient setting. J. Cogn. Ther. 2, 152–159. 10.1521/ijct.2009.2.2.152
    1. *. Nordahl H. M., Borkovec T. D., Hagen R., Kennair L. E., Hjemdal O., Solem S., et al. . (2018). Metacognitive therapy versus cognitive–behavioural therapy in adults with generalised anxiety disorder. BJPsych Open 4, 393–400. 10.1192/bjo.2018.54
    1. Normann N., Emmerik A. A., Morina N. (2014). The efficacy of metacognitive therapy for anxiety and depression: a meta-analytic review. Depress. Anxiety 31, 402–411. 10.1002/da.22273
    1. Papageorgiou C., Wells A. (2001). Positive beliefs about depressive rumination: development and preliminary validation of a self-report scale. Behav. Ther. 32, 13–26. 10.1016/s0005-7894(01)80041-1
    1. *. Papageorgiou C., Wells A. (2015). Group metacognitive therapy for severe antidepressant and CBT resistant depression: a baseline-controlled trial. Cognit. Ther. Res. 39, 14–22. 10.1007/s10608-014-9632-x
    1. Papageorgiou C., Wells A., Meina L. J. (2003). Development and Preliminary Evaluation of the Negative Beliefs About Rumination Scale. Unpublished manuscript.
    1. *. Rabiei M., Mulkens S., Kalantari M., Molavi H., Bahrami F. (2012). Metacognitive therapy for body dysmorphic disorder patients in Iran: acceptability and proof of concept. J. Behav. Ther. Exp. Psychiatry 43, 724–729. 10.1016/j.jbtep.2011.09.013
    1. *. Ramezani M. A., Ahmadi K., Besharat M., Noohi S., Ghaemmaghami A. (2017). Efficacy of metacognitive therapy for hypoactive sexual desire disorder among Iranian couples. Psychother. Res. 28, 902–908. 10.1080/10503307.2017.1301690
    1. Rochat L., Manolov R., Billieux J. (2018). Efficacy of metacognitive therapy in improving mental health: a meta-analysis of single-case studies. J. Clin. Psychol. 74, 896–915. 10.1002/jclp.22567
    1. *. Shareh H., Dolatshahi B. (2012). Effectiveness of Group Metacognitive Therapy in Major Depressive Disorder. Unpublished Manuscript.
    1. Sterne J. A., Sutton A. J., Ioannidis J. P., Terrin N., Jones D. R., Lau J., Schmid C. H. (2011). Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343:d4002. 10.1136/bmj.d4002
    1. Sun X., Zhu C., So S. H. W. (2017). Dysfunctional metacognition across psychopathologies: a meta-analytic review. Eur. Psychiatry 45, 139–153. 10.1016/j.eurpsy.2017.05.029
    1. van der Heiden C., Melchior K. (2014). A 30-month follow-up of generalized anxiety disorder: status after metacognitive therapy and intolerance of uncertainty-therapy. Eur. J. Person Centered Healthcare 2, 434–438. 10.5750/ejpch.v2i4.812
    1. *. van der Heiden C., Melchior K., de Stigter E. (2013). The effectiveness of group metacognitive therapy for generalised anxiety disorder: a pilot study. J. Contemp. Psychother. 1–7 10.1007/s10879-013-9235-y
    1. *. van der Heiden C., Muris P., van der Molen H. (2012). Randomized controlled trial on the effectiveness of metacognitive therapy and intolerance-of-uncertainty therapy for generalized anxiety disorder. Behav. Res. Ther. 50, 100–109. 10.1016/j.brat.2011.12.005
    1. *. van der Heiden C., van Rossen K., Dekker A., Damstra M., Deen M. (2016). Metacognitive therapy for obsessive–compulsive disorder: a pilot study. J. Obsessive Compuls. Relat. Disord. 9, 24–29. 10.1016/j.jocrd.2016.02.002
    1. Wells A. (1990). Panic disorder in association with relaxation induced anxiety: an attentional training approach to treatment. Behav. Ther. 21, 273–280. 10.1016/S0005-7894(05)80330-2
    1. Wells A. (2009). Metacognitive Therapy for Anxiety and Depression. New York, NY; London: Guilford Press.
    1. Wells A., Cartwright-Hatton S. (2004). A short form of the metacognitions questionnaire: properties of the MCQ-30. Behav. Res. Ther. 42, 385–396. 10.1016/s0005-7967(03)00147-5
    1. *. Wells A., Colbear J. (2012). Treating posttraumatic stress disorder with metacognitive therapy: a preliminary controlled trial. J. Clin. Psychol. 68, 373–381. 10.1002/jclp.20871
    1. *. Wells A., King P. (2006). Metacognitive therapy for generalized anxiety disorder: an open trial. J. Behav. Ther. Exp. Psychiatry 37, 206–212. 10.1016/j.jbtep.2005.07.002
    1. Wells A., Matthews G. (1994). Attention and Emotion: A Clinical Perspective. Hove: Psychology Press.
    1. Wells A., Matthews G. (1996). Modelling cognition in emotional disorder: the S-REF model. Behav. Res. Ther. 34, 881–888. 10.1016/S0005-7967(96)00050-2
    1. *. Wells A., Fisher P., Myers S., Wheatley J., Patel T., Brewin C. (2012). Metacognitive therapy in treatment-resistant depression: a platform trial. Behav. Res. Ther. 50, 367–373. 10.1016/j.brat.2012.02.004
    1. *. Wells A., Walton D., Lovell K., Proctor D. (2015). Metacognitive therapy versus prolonged exposure in adults with chronic post-traumatic stress disorder: a parallel randomized controlled trial. Cognit. Ther. Res. 39, 70–80. 10.1007/s10608-014-9636-6
    1. Wells A., Welford M., Fraser J., King P., Mendel E., Wisely J., Rees D. (2008). Chronic PTSD treated with metacognitive therapy: an open trial. Cogn. Behav. Pract. 15, 85–92. 10.1016/j.cbpra.2006.11.005
    1. *. Wells A., Welford M., King P., Papageorgiou C., Wisely J., Mendel E. (2010). A pilot randomized trial of metacognitive therapy vs applied relaxation in the treatment of adults with generalized anxiety disorder. Behav. Res. Ther. 48, 429–434. 10.1016/j.brat.2009.11.013
    1. *. Wenn J. A. (2017). Development and Testing of Metacognitive Therapy for Prolonged Grief Disorder: A Randomised Controlled Trial. Doctoral thesis, Curtin University. Available online at:
    1. World Health Organization (1992). The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: World Health Organization.
    1. *. Zemestani M., Davoodi I., Honarmand M. M., Zargar Y., Ottaviani C. (2016). Comparative effects of group metacognitive therapy versus behavioural activation in moderately depressed students. J. Mental Health 25, 479–485. 10.3109/09638237.2015.1057326

Source: PubMed

3
구독하다