Complex Regional Pain Syndrome: A Comprehensive Review

Samantha-Su Taylor, Nazir Noor, Ivan Urits, Antonella Paladini, Monica Sri Sadhu, Clay Gibb, Tyler Carlson, Dariusz Myrcik, Giustino Varrassi, Omar Viswanath, Samantha-Su Taylor, Nazir Noor, Ivan Urits, Antonella Paladini, Monica Sri Sadhu, Clay Gibb, Tyler Carlson, Dariusz Myrcik, Giustino Varrassi, Omar Viswanath

Abstract

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Type II is when there is known associated nerve injury. Female gender is a risk factor for developing CRPS. Other risk factors include fibromyalgia and rheumatoid arthritis. Unfortunately, the pathogenesis of CRPS is not yet clarified. Some studies have demonstrated different potential pathways. Neuropathic inflammation, specifically activation of peripheral nociceptors of C-fibers, has been shown to play a critical role in developing CRPS. The autonomic nervous system (ANS) is involved. Depending on whether it is acute or chronic CRPS, norepinephrine levels are either decreased or increased, respectively. Some studies have suggested the importance of genetics in developing CRPS. More consideration is being given to the role of psychological factors. Some association between a history of depression and/or post-traumatic stress disorder (PTSD) and the diagnosis of CRPS has been demonstrated. Treatment modalities available range from physical therapy, pharmacotherapy, and interventional techniques. Physical and occupational therapies include mirror therapy and graded motor imagery. Medical management with non-steroidal anti-inflammatory drugs (NSAIDs) has not shown significant improvement. There have been supporting findings in the use of short-course steroids, bisphosphonates, gabapentin, and ketamine. Antioxidant treatment has also shown some promise. Other pharmacotherapies include low-dose naltrexone and Botulinum toxin A (BTX-A). Sympathetic blocks are routinely used, even if their short- and long-term effects are not clear. Finally, spinal cord stimulation (SCS) has been used for decades. In conclusion, CRPS is a multifactorial condition that still requires further studying to better understand its pathogenesis, epidemiology, genetic involvement, psychological implications, and treatment options. Future studies are warranted to better understand this syndrome. This will provide an opportunity for better prevention, diagnosis, and treatment of CRPS.

Keywords: Algoneurodystrophy; Causalgia; Complex regional pain syndrome (CRPS); Post-traumatic stress disorder (PTSD); Reflex sympathetic dystrophy (RSD); Sudeck atrophy.

© 2021. The Author(s).

References

    1. Ott S, Maihöfner C. Signs and symptoms in 1,043 patients with complex regional pain syndrome. J Pain. 2018;19(6):599–611. doi: 10.1016/j.jpain.2018.01.004.
    1. Mertz K, Trunzter J, Wu E, Barnes J, Eppler SL, Kamal RN. National trends in the diagnosis of CRPS after open and endoscopic carpal tunnel release. J Wrist Surg. 2019;08(03):209–214. doi: 10.1055/s-0039-1678674.
    1. Jo Y-H, Kim K, Lee B-G, Kim J-H, Lee C-H, Lee K-H. Incidence of and risk factors for complex regional pain syndrome type 1 after surgery for distal radius fractures: a population-based study. Sci Rep. 2019 doi: 10.1038/S41598-019-41152-X.
    1. Marinus J, Moseley GL, Birklein F, et al. Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol. 2011;10(7):637–648. doi: 10.1016/S1474-4422(11)70106-5.
    1. Goh EL, Chidambaram S, Ma D. Complex regional pain syndrome: a recent update. Burn Trauma. 2017 doi: 10.1186/s41038-016-0066-4.
    1. Eldufani J, Elahmer N, Blaise G. A medical mystery of complex regional pain syndrome. Heliyon. 2020;6(2):e03329. doi: 10.1016/j.heliyon.2020.e03329.
    1. Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth. 2019;123(2):e424–e433. doi: 10.1016/j.bja.2019.03.030.
    1. Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD. Complex regional pain syndrome, current concepts and treatment options. Curr Pain Headache Rep. 2018 doi: 10.1007/s11916-018-0667-7.
    1. Misidou C, Papagoras C. Complex regional pain syndrome: an update. Mediterr J Rheumatol. 2019;30(1):16–25. doi: 10.31138/mjr.30.1.16.
    1. Elsharydah A, Loo NH, Minhajuddin A, Kandil ES. Complex regional pain syndrome type 1 predictors—epidemiological perspective from a national database analysis. J Clin Anesth. 2017 doi: 10.1016/j.jclinane.2017.03.027.
    1. Murphy KR, Han JL, Yang S, Hussaini SM, Elsamadicy AA, Parente B, Xie J, Pagadala LS. Prevalence of specific types of pain diagnoses in a sample of United States adults. Pain Physician. 2017;20(2):E257–E268.
    1. Elsamadicy AA, Yang S, Sergesketter AR, et al. Prevalence and cost analysis of complex regional pain syndrome (CRPS): a role for neuromodulation. Neuromodulation. 2018;21(5):423–430. doi: 10.1111/ner.12691.
    1. Karri J, Palmer JS, Charnay A, et al. Utility of electrical neuromodulation for treating chronic pain syndromes in the pediatric setting: a systematic review. Neuromodulation. 2021 doi: 10.1111/ner.13365.
    1. Weissmann R, Uziel Y. Pediatric complex regional pain syndrome: a review. Pediatr Rheumatol. 2016 doi: 10.1186/s12969-016-0090-8.
    1. Wiper A, Amoroso G, Rao S, Nolan J. Complex regional pain syndrome: a rare but potentially disabling complication of transradial cardiac catheterization. Catheter Cardiovasc Interv. 2020;95(5):E140–E143. doi: 10.1002/ccd.28357.
    1. Crijns TJ, Van Der Gronde BATD, Ring D, Leung N. Complex regional pain syndrome after distal radius fracture is uncommon and is often associated with fibromyalgia. Clin Orthop Relat Res. 2018;476(4):744–750. doi: 10.1007/s11999.0000000000000070.
    1. Rochlin DH, Sheckter CC, Satteson ES, Swan CC, Fox PM, Curtin C. Separating fact from fiction: a nationwide longitudinal examination of complex regional pain syndrome following treatment of Dupuytren contracture. Hand. 2020 doi: 10.1177/1558944720963915.
    1. van Velzen GAJ, Huygen FJPM, van Kleef M, van Eijs FV, Marinus J, van Hilten JJ. Sex matters in complex regional pain syndrome. Eur J Pain (United Kingdom) 2019;23(6):1108–1116. doi: 10.1002/ejp.1375.
    1. Lipman MD, Hess DE, Werner BC, Deal DN. Fibromyalgia as a predictor of complex regional pain syndrome after distal radius fracture. Hand. 2019;14(4):516–522. doi: 10.1177/1558944717735949.
    1. Birklein F, Ajit SK, Goebel A, Perez RSGM, Sommer C. Complex regional pain syndrome-phenotypic characteristics and potential biomarkers. Nat Rev Neurol. 2018;14(5):272–284. doi: 10.1038/nrneurol.2018.20.
    1. Ward D, Thorsen NM, Frisch M, Valentiner-Branth P, Mølbak K, Hviid A. A cluster analysis of serious adverse event reports after human papillomavirus (HPV) vaccination in Danish girls and young women, September 2009 to August 2017. Euro Surveill. 2019;24(19):1. doi: 10.2807/1560-7917.ES.2019.24.19.1800380.
    1. Hviid A, Thorsen NM, Valentiner-Branth P, Frisch M, Mølbak K. Association between quadrivalent human papillomavirus vaccination and selected syndromes with autonomic dysfunction in Danish females: population based, self-controlled, case series analysis. BMJ. 2020 doi: 10.1136/bmj.m2930.
    1. Barboi A, Gibbons CH, Axelrod F, et al. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci Basic Clin. 2020;223(1):13–18. doi: 10.1016/j.autneu.2019.05.002.
    1. Baronio M, Sadia H, Paolacci S, et al. Molecular aspects of regional pain syndrome. Pain Res Manag. 2020 doi: 10.1155/2020/7697214.
    1. Li WW, Guo TZ, Shi X, et al. Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome. J Neuroinflamm. 2018;15(1):105. doi: 10.1186/s12974-018-1145-1.
    1. Dirckx M, Stronks DL, Van Bodegraven-Hof EAM, Wesseldijk F, Groeneweg JG, Huygen FJPM. Inflammation in cold complex regional pain syndrome. Acta Anaesthesiol Scand. 2015;59(6):733–739. doi: 10.1111/aas.12465.
    1. Sommer C, Leinders M, Üçeyler N. Inflammation in the pathophysiology of neuropathic pain. Pain. 2018;159(3):595–602. doi: 10.1097/j.pain.0000000000001122.
    1. Wehmeyer C, Pap T, Buckley CD, Naylor AJ. The role of stromal cells in inflammatory bone loss. Clin Exp Immunol. 2017;189(1):1–11. doi: 10.1111/cei.12979.
    1. Russo MA, Georgius P, Pires AS, et al. Novel immune biomarkers in complex regional pain syndrome. J Neuroimmunol. 2020;347:577330. doi: 10.1016/j.jneuroim.2020.577330.
    1. Bharwani KD, Dik WA, Dirckx M, Huygen FJPM. Highlighting the role of biomarkers of inflammation in the diagnosis and management of complex regional pain syndrome. Mol Diagn Ther. 2019;23(5):615–626. doi: 10.1007/s40291-019-00417-x.
    1. Littlejohn G. Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome. Nat Rev Rheumatol. 2015;11:639–648. doi: 10.1038/nrrheum.2015.100.
    1. Birklein F, Drummond PD, Li W, et al. Activation of cutaneous immune responses in complex regional pain syndrome. J Pain. 2014;15(5):485–495. doi: 10.1016/j.jpain.2014.01.490.
    1. Yvon A, Faroni A, Reid AJ, Lees VC. Selective fiber degeneration in the peripheral nerve of a patient with severe complex regional pain syndrome. Front Neurosci. 2018;12(APR):207. doi: 10.3389/fnins.2018.00207.
    1. Knudsen LF, Terkelsen AJ, Drummond PD, Birklein F. Complex regional pain syndrome: a focus on the autonomic nervous system. Clin Auton Res. 2019;29(4):457–467. doi: 10.1007/s10286-019-00612-0.
    1. Kortekaas MC, Niehof SP, Stolker RJ, Huygen FJPM. Pathophysiological mechanisms involved in vasomotor disturbances in complex regional pain syndrome and implications for therapy: a review. Pain Pract. 2016;16(7):905–914. doi: 10.1111/papr.12403.
    1. Drummond PD, Morellini N, Finch PM, Birklein F, Knudsen LF. Complex regional pain syndrome. Pain. 2018;159(11):2296–2305. doi: 10.1097/j.pain.0000000000001335.
    1. Chen S-S, Zhang J-M. Progress in sympathetically mediated pathological pain. J Anesth Perioper Med. 2015;2(4):216–225. doi: 10.24015/japm.2015.0029.
    1. Xie W, Strong JA, Zhang JM. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience. 2015;291:317–330. doi: 10.1016/j.neuroscience.2015.02.010.
    1. Tajerian M, Clark JD. New concepts in complex regional pain syndrome. Hand Clin. 2016;32(1):41–49. doi: 10.1016/j.hcl.2015.08.003.
    1. Cuhadar U, Gentry C, Vastani N, et al. Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors. Pain. 2019;160(12):2855–2865. doi: 10.1097/j.pain.0000000000001662.
    1. David Clark J, Tawfik VL, Tajerian M, Kingery WS. Autoinflammatory and autoimmune contributions to complex regional pain syndrome. Mol Pain. 2018 doi: 10.1177/1744806918799127.
    1. Dubuis E, Thompson V, Leite MI, et al. Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors. Pain. 2014;155(11):2408–2417. doi: 10.1016/j.pain.2014.09.022.
    1. Kohr D, Singh P, Tschernatsch M, et al. Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain. 2011;152(12):2690–2700. doi: 10.1016/j.pain.2011.06.012.
    1. Tan W, Song Y, Mo C, Jiang S, Wang Z. Analysis of gene expression profile microarray data in complex regional pain syndrome. Mol Med Rep. 2017;16(3):3371–3378. doi: 10.3892/mmr.2017.6950.
    1. Bruehl S, Gamazon ER, Van De Ven T, et al. DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury HHS Public Access. Pain. 2019;160(10):2328–2337. doi: 10.1097/j.pain.0000000000001624.
    1. Van Rooijen DE, Roelen DL, Verduijn W, et al. Genetic HLA associations in complex regional pain syndrome with and without dystonia. J Pain. 2012;13(8):784–789. doi: 10.1016/j.jpain.2012.05.003.
    1. D’Agnelli S, Gerra MC, Bignami E, Arendt-Nielsen L. Exosomes as a new pain biomarker opportunity. Mol Pain. 2020;16:1–9. doi: 10.1177/1744806920957800.
    1. Park HY, Jang YE, Oh S, Lee PB. Psychological characteristics in patients with chronic complex regional pain syndrome: comparisons with patients with major depressive disorder and other types of chronic pain. J Pain Res. 2020;13:389–398. doi: 10.2147/JPR.S230394.
    1. Speck V, Schlereth T, Birklein F, Maihöfner C. Increased prevalence of posttraumatic stress disorder in CRPS. Eur J Pain. 2017;21(3):466–473. doi: 10.1002/ejp.940.
    1. Halicka M, Vittersø AD, Proulx MJ, Bultitude JH. Neuropsychological changes in complex regional pain syndrome (CRPS) Behav Neurol. 2020;2020:1–30. doi: 10.1155/2020/4561831.
    1. Harden RN, Bruehl S, Perez RSGM, et al. Validation of proposed diagnostic criteria (the “Budapest Criteria”) for complex regional pain syndrome. Pain. 2010;150(2):268–274. doi: 10.1016/j.pain.2010.04.030.
    1. Baygutalp F, Kul A. Effect of early orthopedic rehabilitation on development of complex regional pain syndrome type 1. Eurasian J Med. 2020;52(2):110–114. doi: 10.5152/eurasianjmed.2020.19231.
    1. Lewis JS, Kellett S, McCullough R, et al. Body perception disturbance and pain reduction in longstanding complex regional pain syndrome following a multidisciplinary rehabilitation program. Pain Med (United States) 2019;20(11):2213–2219. doi: 10.1093/pm/pnz176.
    1. Smart KM, Wand BM, O’Connell NE. Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II. Cochrane Database Syst Rev. 2016 doi: 10.1002/14651858.CD010853.pub2.
    1. Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E. Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: a systematic review. J Back Musculoskelet Rehabil. 2017;30(3):441–449. doi: 10.3233/BMR-150500.
    1. McGee C, Skye J, Van Heest A. Graded motor imagery for women at risk for developing type I CRPS following closed treatment of distal radius fractures: a randomized comparative effectiveness trial protocol. BMC Musculoskelet Disord. 2018 doi: 10.1186/s12891-018-2115-6.
    1. Wertli MM, Kessels AGH, Perez RSGM, Bachmann LM, Brunner F. Rational pain management in complex regional pain syndrome 1 (CRPS 1)—a network meta-analysis. Pain Med (United States) 2014;15(9):1575–1589. doi: 10.1111/pme.12466.
    1. Krumova E, Breuer AJ, Mainka T, Hansel N, Maier C, Krumova EK. Short-term treatment with parecoxib for complex regional pain syndrome: a randomized, placebo-controlled double-blind trial. Pain Physician. 2014;17:127–137. doi: 10.36076/ppj.2014/17/127.
    1. Eraghi AS, Khazanchin A, Hosseinzadeh N, Pahlevansabagh A. A randomized controlled trial on Aspirin and complex regional pain syndrome after radius fractures. Eur J Transl Myol. 2020;30(1):1–8. doi: 10.4081/ejtm.2019.8643.
    1. Kalita J, Vajpayee A, Misra UK. Comparison of prednisolone with piroxicam in complex regional pain syndrome following stroke: a randomized controlled trial. QJM Mon J Assoc Physicians. 2006;99(2):89–95. doi: 10.1093/qjmed/hcl004.
    1. Barbalinardo S, Loer SA, Goebel A, Perez RSGM. The treatment of longstanding complex regional pain syndrome with oral steroids. Pain Med. 2016;17(2):337–343. doi: 10.1093/pm/pnv002.
    1. Jamroz A, Berger M, Winston P. Prednisone for acute complex regional pain syndrome: a retrospective cohort study. Pain Res Manag. 2020 doi: 10.1155/2020/8182569.
    1. Żyluk A, Puchalski P. Effectiveness of complex regional pain syndrome treatment: a systematic review. Neurol Neurochir Pol. 2018;52(3):326–333. doi: 10.1016/j.pjnns.2018.03.001.
    1. Xu J, Yang J, Lin P, Rosenquist E, Cheng J. Intravenous therapies for complex regional pain syndrome. Anesth Analg. 2016;122(3):843–856. doi: 10.1213/ANE.0000000000000999.
    1. Young HE, Hyeyun K, Hee IS. Pamidronate effect compared with a steroid on complex regional pain syndrome type I: pilot randomised trial. Neth J Med. 2016;74(1):30–35.
    1. Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A. Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: a systematic literature review and meta-analysis of randomized controlled trials versus placebo. Jt Bone Spine. 2017;84(4):393–399. doi: 10.1016/j.jbspin.2017.03.009.
    1. Wiffen PJ, Derry S, Bell RF, et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 doi: 10.1002/14651858.CD007938.pub4.
    1. O’Connell NE, Wand BM, Mcauley J, Marston L, Moseley GL. Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews. Cochrane Database Syst Rev. 2013 doi: 10.1002/14651858.CD009416.pub2.
    1. Brown S, Johnston B, Amaria K, et al. A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children. Scand J Pain. 2016;13:156–163. doi: 10.1016/j.sjpain.2016.05.039.
    1. Yang Y, Maher DP, Cohen SP. Emerging concepts on the use of ketamine for chronic pain. Expert Rev Clin Pharmacol. 2020;13(2):135–146. doi: 10.1080/17512433.2020.1717947.
    1. Schwartzman RJ, Alexander GM, Grothusen JR. The use of ketamine in complex regional pain syndrome: possible mechanisms. Expert Rev Neurother. 2011;11(5):719–734. doi: 10.1586/ern.11.31.
    1. Zhao J, Wang Y, Wang D. The Effect of ketamine infusion in the treatment of complex regional pain syndrome: a systemic review and meta-analysis. Curr Pain Headache Rep. 2018;22(2):1–8. doi: 10.1007/s11916-018-0664-x.
    1. Finch PM, Knudsen L, Drummond PD. Reduction of allodynia in patients with complex regional pain syndrome: a double-blind placebo-controlled trial of topical ketamine. Pain. 2009;146(1–2):18–25. doi: 10.1016/j.pain.2009.05.017.
    1. Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E, Perreault M. Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo-controlled study. Pain. 2009;147(1–3):107–115. doi: 10.1016/j.pain.2009.08.015.
    1. Kiefer RT, Rohr P, Ploppa A, et al. Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Pain Med. 2008;9(8):1173–1201. doi: 10.1111/j.1526-4637.2007.00402.x.
    1. Azari P, Lindsay DR, Briones D, Clarke C, Buchheit T, Pyati S. Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review. CNS Drugs. 2012;26(3):215–228. doi: 10.2165/11595200-000000000-00000.
    1. Perez RSGM, Zuurmond WWA, Bezemer PD, et al. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain. 2003;102(3):297–307. doi: 10.1016/S0304-3959(02)00414-1.
    1. Chen S, Roffey DM, Dion CA, Arab A, Wai EK. Effect of perioperative Vitamin C supplementation on postoperative pain and the incidence of chronic regional pain syndrome: a systematic review and meta-analysis. Clin J Pain. 2016;32(2):179–185. doi: 10.1097/AJP.0000000000000218.
    1. Meena S, Sharma P, Gangary SK, Chowdhury B. Role of vitamin C in prevention of complex regional pain syndrome after distal radius fractures: a meta-analysis. Eur J Orthop Surg Traumatol. 2015;25(4):637–641. doi: 10.1007/s00590-014-1573-2.
    1. Aïm F, Klouche S, Frison A, Bauer T, Hardy P. Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: a systematic review and meta-analysis. Orthop Traumatol Surg Res. 2017;103(3):465–470. doi: 10.1016/j.otsr.2016.12.021.
    1. Trofimovitch D, Baumrucker SJ. Pharmacology update: low-dose naltrexone as a possible nonopioid modality for some chronic, nonmalignant pain syndromes. Am J Hosp Palliat Med. 2019;36(10):907–912. doi: 10.1177/1049909119838974.
    1. Chopra P, Cooper MS. Treatment of complex regional pain syndrome (CRPS) using low dose naltrexone (LDN) J Neuroimmune Pharmacol. 2013;8(3):470–476. doi: 10.1007/s11481-013-9451-y.
    1. Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009;10(4):663–672. doi: 10.1111/j.1526-4637.2009.00613.x.
    1. Argoff CE. A focused review on the use of botulinum toxins for neuropathic pain. Clin J Pain. 2002 doi: 10.1097/00002508-200211001-00010.
    1. Siongco PRL, Rosales RL, Moore AP, et al. Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study. J Neural Transm. 2020;127(6):935–951. doi: 10.1007/s00702-020-02163-5.
    1. Birthi P, Sloan P, Salles S. Subcutaneous botulinum toxin A for the treatment of refractory complex regional pain syndrome. PM&R. 2012;4(6):446–449. doi: 10.1016/j.pmrj.2011.12.010.
    1. Safarpour D, Jabbari B. Botulinum toxin A (BOTOX) for treatment of proximal myofascial pain in complex regional pain syndrome: two cases. Pain Med. 2010;11(9):1415–1418. doi: 10.1111/j.1526-4637.2010.00929.x.
    1. Lessard L, Bartow MJ, Lee J, Diaz-Abel J, Tessler OES. Botulinum toxin A. Plast Reconstr Surg Glob Open. 2018;6(10):e1847. doi: 10.1097/GOX.0000000000001847.
    1. Alexander GM, Aradillas E, Schwartzman RJ, Grothusen JR, Goebel A. Retrospective study plasma exchange therapy in patients with complex regional pain syndrome. Pain Physician. 2015;18:383–394. doi: 10.36076/ppj.2015/18/383.
    1. Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA J Am Med Assoc. 2015;313(24):2474–2483. doi: 10.1001/jama.2015.6199.
    1. Andreae MH, Carter GM, Shaparin N, et al. Inhaled cannabis for chronic neuropathic pain: a meta-analysis of individual patient data. J Pain. 2015;16(12):1221–1232. doi: 10.1016/j.jpain.2015.07.009.
    1. Whiting PF, Wolff RF, Deshpande S, et al. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA J Am Med Assoc. 2015;313(24):2456–2473. doi: 10.1001/jama.2015.6358.
    1. Meng H, Johnston B, Englesakis M, Moulin DE, Bhatia A. Selective cannabinoids for chronic neuropathic pain: a systematic review and meta-analysis. Anesth Analg. 2017;125(5):1638–1652. doi: 10.1213/ANE.0000000000002110.
    1. Stockings E, Campbell G, Hall WD, et al. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain. 2018;159(10):1932–1954. doi: 10.1097/j.pain.0000000000001293.
    1. Almog S, Aharon-Peretz J, Vulfsons S, et al. The pharmacokinetics, efficacy, and safety of a novel selective-dose cannabis inhaler in patients with chronic pain: a randomized, double-blinded, placebo-controlled trial. Eur J Pain (United Kingdom) 2020;24(8):1505–1516. doi: 10.1002/ejp.1605.
    1. Zernikow B, Wager J, Brehmer H, Hirschfeld G, Maier C. Invasive treatments for complex regional pain syndrome in children and adolescents: a scoping review. Anesthesiology. 2015;122(3):699–707. doi: 10.1097/ALN.0000000000000573.
    1. Cheng J, Salmasi V, You J, et al. Outcomes of sympathetic blocks in the management of complex regional pain syndrome: a retrospective cohort study. Anesthesiology. 2019;131(4):883–893. doi: 10.1097/ALN.0000000000002899.
    1. O’Connell NE, Wand BM, Gibson W, Carr DB, Birklein F, Stanton TR. Local anaesthetic sympathetic blockade for complex regional pain syndrome. Cochrane Database Syst Rev. 2016;2016(7):1–57. doi: 10.1002/14651858.CD004598.pub4.
    1. Yang S, Chang MC. Effect of repetitive transcranial magnetic stimulation on pain management: a systematic narrative review. Front Neurol. 2020;11:114. doi: 10.3389/fneur.2020.00114.
    1. Isagulyan E, Slavin K, Konovalov N, et al. Spinal cord stimulation in chronic pain: technical advances. Korean J Pain. 2020;33(2):99–107. doi: 10.3344/kjp.2020.33.2.99.
    1. Melzack R, Wall PD. Pain mechanisms: a new theory. Science (80-). 1965;150(3699):971–979. doi: 10.1126/science.150.3699.971.
    1. Lind AL, Emami Khoonsari P, Sjödin M, et al. Spinal cord stimulation alters protein levels in the cerebrospinal fluid of neuropathic pain patients: a proteomic mass spectrometric analysis. Neuromodulation. 2016;19(6):549–562. doi: 10.1111/ner.12473.
    1. Gill JS, Asgerally A, Simopoulos TT. High-frequency spinal cord stimulation at 10 kHz for the treatment of complex regional pain syndrome: a case series of patients with or without previous spinal cord stimulator implantation. Pain Pract. 2019;19(3):289–294. doi: 10.1111/papr.12739.
    1. Chmiela MA, Hendrickson M, Hale J, et al. Direct peripheral nerve stimulation for the treatment of complex regional pain syndrome: a 30-year review. Neuromodulation. 2020 doi: 10.1111/ner.13295.
    1. Frederico TN, da Silva FT. Peripheral nerve stimulation of the brachial plexus for chronic refractory CRPS pain of the upper limb: description of a new technique and case series. Pain Med. 2020;21(1):S18–S26. doi: 10.1093/pm/pnaa201.
    1. Deer TR, Levy RM, Kramer J, et al. Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. Pain. 2017;158(4):669–681. doi: 10.1097/j.pain.0000000000000814.
    1. Ayyaswamy B, Saeed B, Anand A, Chan L, Shetty V. Quality of life after amputation in patients with advanced complex regional pain syndrome: a systematic review. EFORT Open Rev. 2019;4(9):533–540. doi: 10.1302/2058-5241.4.190008.
    1. Stoehr JR, Sood R, Jordan SW, Dumanian GA. Targeted muscle reinnervation at the time of amputation in the management of complex regional pain syndrome of the lower extremity. Microsurgery. 2020;40(8):852–858. doi: 10.1002/micr.30653.
    1. Poppler LH, Mackinnon SE. The role of the peripheral nerve surgeon in the treatment of pain. Neurotherapeutics. 2019;16(1):9–25. doi: 10.1007/s13311-018-00695-z.
    1. Goebel A, Jacob A, Frank B, et al. Mycophenolate for persistent complex regional pain syndrome, a parallel, open, randomised, proof of concept trial. Scand J Pain. 2018;18(1):29–37. doi: 10.1515/sjpain-2017-0154.
    1. Lee SH, Yoo SH, Lee HJ, et al. Anti-allodynic effects of polydeoxyribonucleotide in an animal model of neuropathic pain and complex regional pain syndrome. J Korean Med Sci. 2020 doi: 10.3346/JKMS.2020.35.E225.
    1. Chau B, Phelan I, Ta P, et al. Immersive virtual reality for pain relief in upper limb complex regional pain syndrome: a pilot study. Innov Clin Neurosci. 2020;17(4–6):47–52.

Source: PubMed

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