Global, regional and national burden of low back pain 1990-2019: A systematic analysis of the Global Burden of Disease study 2019

Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao, Zengwu Shao, Guozhi Xiao, Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao, Zengwu Shao, Guozhi Xiao

Abstract

Background: To comprehensively analyze the global level and trends of prevalence, incidence and years lived with disability (YLDs) for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI).

Methods: Publicly available modelled data and methods were obtained from the Global Burden of Diseases (GBD) study 2019, and used to evaluate the global burden of LBP through a systematic analysis.

Results: Globally, the age-standardized prevalence, incidence and YLDs rate of LBP were slightly decreased from 1990 to 2019, but the number of the prevalent cases, incident cases and YLDs had substantially increased, and LBP remains the leading cause of YLDs in 2019 worldwide. The number of prevalent cases was increased with age and peaked at the age of 45-54 years for both sexes, and the global prevalence rate was higher in females than in males and increased with age, peaking at the 80-84 age group in both sexes in 2019. Overall, a positive association between the age-standardized YLD rate and SDI was observed over the past thirty years. At the national revel, the United States, Denmark and Switzerland had the three highest levels of age-standardized prevalence, while Zambia, Zimbabwe and Canada showed the highest increase in the age-standardized prevalence during 1990-2019.

Conclusions: LBP is a major public health issue globally, and its burden remains high. Increasing population awareness about its risk factors and preventive measures for LBP are needed to reduce the future burden of this condition.

The translational potential of this article: Due to the high prevalence and heavy burden of LBP globally, it is important to update its epidemiological data. This systematic analysis provides researchers and healthcare policy makers with up-to-date, comprehensive and comparable information on global LBP burden, which is of clinical translational significance.

Keywords: Epidemiological science; Global burden; Low back pain.

Conflict of interest statement

None declared.

© 2021 The Authors.

Figures

Fig. 1
Fig. 1
Age-standardized prevalence estimates of low back pain per 100,000 population by country in 2019 (generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Fig. 2
Fig. 2
Age-standardized incidence estimates of low back pain per 100,000 population by country in 2019 (generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Fig. 3
Fig. 3
Worldwide prevalent cases and prevalence estimates of low back pain per 100,000 population by age and sex in 2019; Dotted and dashed lines indicate 95 ​% upper and lower uncertainty intervals (95 ​% UI), respectively (generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Fig. 4
Fig. 4
Age-standardized years lived with disability (YLD) rates for low back pain for 21 Global Burden of Disease (GBD) regions by sociodemographic index (SDI) between 1990 and 2019; Expected values based on the SDI and disease rates in all locations are shown as the black line. Thirty points are plotted for each GBD region and show observed age-standardized YLD rates from 1990 to 2019 for that region (generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Fig. 5
Fig. 5
Age-standardized years lived with disability (YLD) rates of low back pain by 204 countries and territories and sociodemographic index (SDI) in 2019; Expected values are shown as the black line. Each point shows observed age-standardized YLD rate for specified country or territory in 2019 (generated from data available from http://ghdx.healthdata.org/gbd-results-tool).

References

    1. Vlaeyen J.W.S., Maher C.G., Wiech K., Van Zundert J., Meloto C.B., Diatchenko L., et al. Low back pain. Nat Rev Dis Primers. 2018;4:52.
    1. Urits I., Burshtein A., Sharma M., Testa L., Gold P.A., Orhurhu V., et al. Low back pain, a comprehensive review: pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep. 2019;23:23.
    1. Hartvigsen J., Hancock M.J., Kongsted A., Louw Q., Ferreira M.L., Genevay S., et al. What low back pain is and why we need to pay attention. Lancet. 2018;391:2356–2367.
    1. Maher C., Underwood M., Buchbinder R. Non-specific low back pain. Lancet. 2017;389:736–747.
    1. GDaIIaP Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789–1858.
    1. Wu A., Dong W., Liu S., Cheung J.P.Y., Kwan K.Y.H., Zeng X., et al. The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016. Pain. 2019;160:237–245.
    1. de David C.N., Deligne L.M.C., da Silva R.S., Malta D.C., Duncan B.B., Passos V.M.A., et al. The burden of low back pain in Brazil: estimates from the Global Burden of Disease 2017 Study. Popul Health Metrics. 2020;18:12.
    1. Stanisławska I., Mincewicz M., Cabak A., Kaczor R., Czarny-Działak M., Witek B., et al. Epidemiological aspects of low back pain. Advances in Biomedicine. 2019:47–52.
    1. Jin Z., Wang D., Zhang H., Liang J., Feng X., Zhao J., et al. Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017. Ann Rheum Dis. 2020;79:1014–1022.
    1. Hoy D., March L., Brooks P., Blyth F., Woolf A., Bain C., et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73:968–974.
    1. Wu A., March L., Zheng X., Huang J., Wang X., Zhao J., et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med. 2020;8:299.
    1. Vos T., Lim S.S., Abbafati C., Abbas K.M., Abbasi M., Abbasifard M., et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1204–1222.
    1. Safiri S., Kolahi A.A., Smith E., Hill C., Bettampadi D., Mansournia M.A., et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017. Ann Rheum Dis. 2020;79:819–828.
    1. Dieleman J.L., Cao J., Chapin A., Chen C., Li Z., Liu A., et al. US health care spending by payer and health condition. J Am Med Assoc. 2020;323:863–884. 1996-2016.
    1. Alonso-Garcia M., Sarria-Santamera A. The economic and social burden of low back pain in Spain: a national assessment of the economic and social impact of low back pain in Spain. Spine (Phila Pa. 1976;45:E1026–E1032. 2020.
    1. Safiri S., Kolahi A.A., Hoy D., Buchbinder R., Mansournia M.A., Bettampadi D., et al. Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017. BMJ. 2020;368:m791.
    1. Wang Y.X.J. Menopause as a potential cause for higher prevalence of low back pain in women than in age-matched men. J Orthop Translat. 2017;8:1–4.
    1. Talsania M., Scofield R.H. Menopause and rheumatic disease. Rheum Dis Clin N Am. 2017;43:287–302.
    1. Kikuchi R., Hirano T., Watanabe K., Sano A., Sato T., Ito T., et al. Gender differences in the prevalence of low back pain associated with sports activities in children and adolescents: a six-year annual survey of a birth cohort in Niigata City, Japan. BMC Muscoskel Disord. 2019;20:327.
    1. Lyu F.J., Cheung K.M., Zheng Z., Wang H., Sakai D., Leung V.Y. IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. Nat Rev Rheumatol. 2019;15:102–112.
    1. Ma K., Chen S., Li Z., Deng X., Huang D., Xiong L., et al. Mechanisms of endogenous repair failure during intervertebral disc degeneration. Osteoarthritis Cartilage. 2019;27:41–48.
    1. Chen S., Liu S., Ma K., Zhao L., Lin H., Shao Z. TGF-beta signaling in intervertebral disc health and disease. Osteoarthritis Cartilage. 2019;27:1109–1117.
    1. Blyth F.M., Noguchi N. Chronic musculoskeletal pain and its impact on older people. Best practice & research. Clin Rheumatol. 2017;31:160–168.
    1. Dancause K.N., Dehuff C., Soloway L.E., Vilar M., Chan C., Wilson M., et al. Behavioral changes associated with economic development in the South Pacific: health transition in Vanuatu. Am J Hum Biol. 2011;23:366–376.
    1. van Horn A., Weitz C.A., Olszowy K.M., Dancause K.N., Sun C., Pomer A., et al. Using multiple correspondence analysis to identify behaviour patterns associated with overweight and obesity in Vanuatu adults. Publ Health Nutr. 2019;22:1533–1544.
    1. Foster N.E., Anema J.R., Cherkin D., Chou R., Cohen S.P., Gross D.P., et al. Prevention and treatment of low back pain: evidence, challenges, and promising directions. Lancet. 2018;391:2368–2383.
    1. Murray C.J.L., Aravkin A.Y., Zheng P., Abbafati C., Abbas K.M., Abbasi-Kangevari M., et al. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1223–1249.
    1. Knezevic N.N., Candido K.D., Vlaeyen J.W.S., Van Zundert J., Cohen S.P. Low back pain. Lancet. 2021;398:78–92. 10294.
    1. de Campos T.F., Maher C.G., Fuller J.T., Steffens D., Attwell S., Hancock M.J. Prevention strategies to reduce future impact of low back pain: a systematic review and meta-analysis. Br J Sports Med. 2020;55(9):468–476.
    1. Huang R., Ning J., Chuter V.H., Taylor J.B., Christophe D., Meng Z., et al. Exercise alone and exercise combined with education both prevent episodes of low back pain and related absenteeism: systematic review and network meta-analysis of randomised controlled trials (RCTs) aimed at preventing back pain. Br J Sports Med. 2020;54:766–770.
    1. Minghelli B., Nunes C., Oliveira R. Back school postural education program: comparison of two types of interventions in improving ergonomic knowledge about postures and reducing low back pain in adolescents. Int J Environ Res Publ Health. 2021;18

Source: PubMed

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