Management of fatigue in persons with multiple sclerosis

Fary Khan, Bhasker Amatya, Mary Galea, Fary Khan, Bhasker Amatya, Mary Galea

Abstract

Fatigue is one of the most common symptoms of multiple sclerosis. Despite advances in pharmacological and non-pharmacological treatment, fatigue continues to be the disabling symptom in persons with MS (pwMS), affecting almost 80% of pwMS. In current practice, both pharmacological and non-pharmacological interventions are used in combination, encompassing a multi-disciplinary approach. The body of research investigating the effect of these interventions is growing. This review systematically evaluated the existing evidence on the effectiveness and safety of different interventions currently applied for the management of fatigue in person with multiple sclerosis in improving patient outcomes, to guide treating clinicians.

Keywords: disability; fatigue; multiple sclerosis; rehabilitation outcomes; symptomatic treatment.

Figures

Figure 1
Figure 1
Clinical decision-making flow chart for treating fatigue in MS. Adapted from MacAllister and Krupp (10).
Figure 2
Figure 2
PRISMA flow diagram showing selection of article review.

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