Lung volume recruitment improves volitional airway clearance in amyotrophic lateral sclerosis

Stuart Cleary, John E Misiaszek, Sonya Wheeler, Sanjay Kalra, Shelagh K Genuis, Wendy S Johnston, Stuart Cleary, John E Misiaszek, Sonya Wheeler, Sanjay Kalra, Shelagh K Genuis, Wendy S Johnston

Abstract

Introduction/aims: In this study we evaluated the effects of lung volume recruitment treatment (LVR), a low-tech, low-cost, manual "breath-stacking" technique used to help people cough with enough force to clear their airways, thereby reducing the risk of aspiration and choking, on five volitional airway clearance and protection behaviors used by people living with amyotrophic lateral sclerosis (PwALS).

Methods: Using a repeated-measures cross-over design, 29 PwALS performed five volitional airway clearance and protection behaviors in LVR treatment and in no-treatment, control conditions. Peak cough flow (PCF) was used to measure maximum expiratory rate during forced expiration, throat clearing, hawking, post-swallow coughing, and the supraglottic swallowing maneuver. Comparisons were made as a function of condition (treatment or control) and three time-points (pretreatment, and 15 and 30 minutes posttreatment).

Results: LVR treatment had a significant positive effect on maximum expiratory rates during all tested airway clearance and protection behaviors. Increased PCF values lasted for up to 30 minutes post-LVR for all tested behaviors in the treatment condition.

Discussion: We found that LVR treatment could increase control over airway clearance in PwALS, as well as provide improved airway protection for up to 30 minutes, the duration of a typical meal. This study has implications for patient care. These include offering patients control over some of the most feared symptoms of ALS, particularly choking during activities of daily living, and enhanced ALS respiratory care in low-resource settings. Findings may have implications for other neurodegenerative disorders in which dysphagia occurs with retained sensory function.

Keywords: activities of daily living; amyotrophic lateral sclerosis; quality of life; rehabilitation; respiratory function.

Conflict of interest statement

The authors declare no potential conflict of interest.

© 2021 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.

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