Behavioral assessment of the reinforcing effect of exercise in women with anorexia nervosa: further paradigm development and data

Diane A Klein, Janet E Schebendach, Marina Gershkovich, Lindsay P Bodell, Richard W Foltin, B Timothy Walsh, Diane A Klein, Janet E Schebendach, Marina Gershkovich, Lindsay P Bodell, Richard W Foltin, B Timothy Walsh

Abstract

Objective: To use a Progressive Ratio (PR) computerized "work" paradigm to measure course and correlates of exercise motivation in in-patients with Anorexia Nervosa (AN).

Method: Sixteen inpatients with AN participated in a PR task assessing the relative reinforcing effect of two different increments of cash versus the opportunity to exercise for upto 30 min, twice; at low weight, and, for n = 10 participants, after weight restoration.

Results: There was a trend toward a higher work for exercise with 2 versus 5 increments of cash as the alternative reinforcer. Exercise breakpoint did not differ between low and normal-weight states. Exercise breakpoint at each time point was correlated with prehospitalization exercise "commitment" (Commitment to Exercise Scale, r = .613, p = .012 at T1; r = .634, p = .049 at T2).

Discussion: Patients with AN will work at a PR task for access to even a small amount of exercise. Exercise motivation during hospitalization is correlated with prehospital exercise commitment and does not appear to change consistently with weight restoration.

© 2009 by Wiley Periodicals, Inc.

Figures

Figure 1
Figure 1
Relationship between pre-admission CES and exercise breakpoint (averaged over two sessions) at 75% IBW in 16 inpatient women with AN.

References

    1. Klein DA, Walsh BT. Eating disorders: clinical features and pathophysiology. Physiol Behav. 2004;81:359–374.
    1. Carter JC, Blackmore E, Sutandar-Pinnock K, Woodside DB. Relapse in anorexia nervosa: a survival analysis. Psychol Med. 2004;34:671–679.
    1. Strober M, Freeman R, Morrell W. The long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10–15 years in a prospective study. Int J Eat Disord. 1997;22:339–360.
    1. Hodos W. Progressive ratio as a measure of reward strength. Science. 1961;134:943–944.
    1. Epstein LH, Leddy JJ. Food reinforcement. Appetite. 2006;46:22–25.
    1. Raynor HA, Epstein LH. The relative-reinforcing value of food under differing levels of food deprivation and restriction. Appetite. 2003;40:15–24.
    1. Temple J, Bulkley A, Badawy R, Krause N, McCann S, Epstein LH. Differential effects of daily snack food intake on the reinforcing value of food in obese and nonobese women. Am J Clin Nutr. 2009 May 20; (Epub ahead of print)
    1. Hill C, Saxton J, Webber L, Blundell J, Wardle J. The relative reinforcing value of food predicts weight gain in a longitudinal study of 7–10-y-old children. Am J Clin Nutr. 2009 Jun 17; (Epub ahead of print)
    1. Lerman C, Jepson C, Wileyto EP, Epstein LH, Rukstalis M, Patterson F, Kaufmann V, et al. Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Neuropsychopharmacology. 2006;31:231–242.
    1. Barkley J, Epstein L, Roemmich J. Reinforcing value of interval and continuous physical activity in children. Physiol Behav. 2009;98:31–36.
    1. Epstein LH, Roemmich JN, Saad FG, Handley EA. The value of sedentary alternatives influences child physical activity choice. Int J Behav Med. 2004;11:236–242.
    1. Saelens BE, Epstein LH. The rate of sedentary activities determines the reinforcing value of physical activity. Health Psychol. 1999;18:655–659.
    1. Schebendach JE, Klein DA, Foltin RW, Devlin MJ, Walsh BT. Relative reinforcing value of exercise in inpatients with anorexia nervosa: model development and pilot data. Int J Eat Dis. 2007;40:446–453.
    1. Davis C, Brewer H, Ratusny D. Behavioral frequency and psychological commitment: necessary concepts in the study of excessive exercising. J Behav Med. 1993;16:611–628.
    1. Mitchell JE, Cook-Myers T, Wonderlich SA. Diagnostic criteria for anorexia nervosa: Looking ahead to DSM-V. Int J Eat Disord. 2005;37:595–597.
    1. Pollock ML, Gaesser GA, Butcher JD, et al. American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc. 1998;30:975–991.
    1. Comer SD, Collins ED, Wilson ST, Donovan MR, Foltin RW, Fischman MW. Effects of an alternative reinforcer on intravenous heroin self-administration by humans. Eur J Pharmacol. 1998;345:13–26.
    1. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–571.
    1. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56:893–897.
    1. Garner DM, Olmsted MP. The eating disorder inventory manual. Odessa, FL: Psychological Assessment Resources; 1984.
    1. Vara LS, Epstein LH. Laboratory assessment of choice between exercise or sedentary behaviors. Res Q Exerc Sport. 1993;64:356–360.
    1. Coleman KJ, Gonzalez EG, Cooley T. An objective measure of reinforcement and its implications for exercise promotion in sedentary Hispanic and Anglo women. Ann Behav Med. 2000;2:229–236.
    1. Klein DA, Bennett AS, Schebendach J, Foltin RW, Devlin MJ, Walsh BT. Exercise “addiction” in anorexia nervosa: model development and pilot data. CNS Spectr. 2004;9:531–537.
    1. Brewerton TD, Stellefson EJ, Hibbs N, Hodges EL, Cochrane CE. Comparison of eating disorder patients with and without compulsive exercising. Int J Eat Disord. 1995;17:413–416.
    1. Davis C, Katzman DK, Kaptein S, et al. The prevalence of high-level exercise in the eating disorders: etiological implications. Compr Psychiatry. 1997;38:321–326.
    1. Shroff H, Reba L, Thornton LM, et al. Features associated with excessive exercise in women with eating disorders. Int J Eat Disord. 2006;39:454–461.
    1. Haney M, Foltin RW, Fischman MW. Effects of pergolide on intravenous cocaine self-administration in men and women. Psychopharmacology. 1998;137:15–24.
    1. Carr KD. Feeding, drug abuse, and the sensitization of reward by metabolic need. Neurochem Res. 1996;21:1455–1467.

Source: PubMed

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