Does binge-eating matter for glycemic control in type 2 diabetes patients?

Marcelo Papelbaum, Rodrigo de Oliveira Moreira, Walmir Ferreira Coutinho, Rosane Kupfer, Silvia Freitas, Ronir Raggio Luz, José Carlos Appolinario, Marcelo Papelbaum, Rodrigo de Oliveira Moreira, Walmir Ferreira Coutinho, Rosane Kupfer, Silvia Freitas, Ronir Raggio Luz, José Carlos Appolinario

Abstract

Background: Eating behavior is an important aspect related to type 2 diabetes mellitus (T2DM) treatment and may have an impact on glycemic control. Previous reports showed elevated prevalence of eating disordered behaviors, especially binge eating disorder in clinical samples of type 2 diabetes patients. However, results regarding the impact of an eating disorder on the glycemic and clinical control of T2DM is inconsistent. The purpose of this study was to assess the impact of a comorbid eating disorder on glycemic control (GC) in a group of patients with T2DM.

Methods: Eating behaviors of 70 consecutive patients with T2DM were assessed using a Structured Clinical Interview for DSM-IV and the Binge Eating Scale. The GC was examined with fasting blood glucose (FBG) and glycated hemoglobin (A1c) levels. In addition, secondary clinical variables were assessed, including body mass index (BMI) and lipids. Chi-square and Student's T tests were used to compare clinical and psychopathological characteristics of patients with and without an ED. In order to evaluate the relationship between GC and eating disorder (ED) a linear regression analysis was performed, controlling for BMI. A significance level of 5% was adopted.

Results: Seventy-seven percent of the sample (n = 54) were female and 50% were obese. Fourteen patients exhibited an ED, mostly binge eating disorder (BED). In a regression analysis, both FBG (beta coefficient = 47.4 (22.3); p = 0.037) and A1c (beta coefficient = 1.12 (0.57); p = 0.05) were predicted by the presence of an ED. However, the presence of an ED lost its impact on glycemic control outcomes after the addition of the BMI in the models.

Conclusions: Eating psychopathology is frequently observed in patients with T2DM. Among individuals with T2DM, co-morbid ED is associated with a poorer glycemic control in the presence of a higher BMI. The presence of an eating disordered behavior in patients with T2DM seems to have clinical relevance in the usual care of patients with diabetes. Therefore, we recommend eating psychopathology should be routinely assessed in T2DM patients.

Keywords: Binge eating disorder; Diabetes mellitus; Glycemic control.

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

References

    1. Thornton LM, Watson HJ, Jangmo A, Welch E, Wiklund C, von Hausswolff-Juhlin Y, et al. Binge-eating disorder in the Swedish national registers: somatic comorbidity. Int J Eat Disord. 2017;50(1):58–65. doi: 10.1002/eat.22624.
    1. Javaras KN, Pope HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, et al. Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry. 2008;69(2):266–273. doi: 10.4088/JCP.v69n0213.
    1. Kessler RC, Berglund PA, Chiu WT, Deitz AC, Hudson JI, Shahly V, et al. The prevalence and correlates of binge eating disorder in the World Health Organization world mental health surveys. Biol Psychiatry. 2013;73(9):904–914. doi: 10.1016/j.biopsych.2012.11.020.
    1. Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors. Postgrad Med J. 2006;82(966):280–284. doi: 10.1136/pmj.2005.039032.
    1. Vetter ML, Amaro A, Volger S. Nutritional management of type 2 diabetes mellitus and obesity and pharmacologic therapies to facilitate weight loss. Postgrad Med. 2014;126(1):139–152. doi: 10.3810/pgm.2014.01.2734.
    1. Mannucci E, Ricca V, Rotella CM. Clinical features of binge eating disorder in type I diabetes: a case report. Int J Eat Disord. 1997;21(1):99–102. doi: 10.1002/(SICI)1098-108X(199701)21:1<99::AID-EAT13>;2-J.
    1. García-Mayor RV, García-Soidán FJ. Eating disoders in type 2 diabetic people: brief review. Diabetes Metab Syndr. 2017;11(3):221–224. doi: 10.1016/j.dsx.2016.08.004.
    1. Herpertz S, Wagener R, Albus C, Kocnar M, Wagner R, Best F. Diabetes mellitus and eating disorders: a multicenter study on the comorbidity of the two diseases. J Psychosom Res. 1998;44(3/4):503–515. doi: 10.1016/S0022-3999(97)00274-2.
    1. Kenardy J, Mensch M, Bowen K, Pearson S. A comparison of eating behaviors in newly diagnosed NIDDM patients and case-matched control subjects. Diabetes Care. 1994;17(10):1197–1199. doi: 10.2337/diacare.17.10.1197.
    1. Ryan M, Gallanagh J, Livingstone MB, Gaillard C, Ritz P. The prevalence of abnormal eating behaviour in a representative sample of the French diabetic population. Diabetes Metab. 2008;34:581–586. doi: 10.1016/j.diabet.2008.05.006.
    1. Mannucci E, Tesi F, Ricca V, Pierazzuoli E, Barciulli E, Moretti S, et al. Eating behavior in obese patients with and without type 2 diabetes mellitus. Int J Obes Relat Metab Disord. 2002;26:848–853. doi: 10.1038/sj.ijo.0801976.
    1. Nicolau J, Simo R, Sanchís P, Ayala L, Fortuny R, Zubillaga I, et al. Eating disorders are frequent among type 2 diabetic patients and are associated with worse metabolic and psychological outcomes: results from a cross-sectional study in primary and secondary care settings. Acta Diabetol. 2015;52(6):1037–1044. doi: 10.1007/s00592-015-0742-z.
    1. Meneghini LF, Spadola J, Florez H. Prevalence and associations of binge eating disorder in a multiethnic population with type 2 diabetes. Diabetes Care. 2006;29(12):2760. doi: 10.2337/dc06-1364.
    1. Crow S, Kendall D, Praus B, Thuras P. Binge eating and other psychopathology in patients with type II diabetes mellitus. Int J Eat Disord. 2001;30:222–226. doi: 10.1002/eat.1077.
    1. Herpertz S, Albus C, Kielmann R, Hagemann-Patt H, Lichtblau K, et al. Comorbidity of diabetes mellitus and eating disorders: A follow-up study. J Psychosom Res. 2001;51:673–678. doi: 10.1016/S0022-3999(01)00246-X.
    1. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33:S62–S69. doi: 10.2337/dc10-S062.
    1. First MB, Spitzer RL, Gibbon M, Williams JB. Structured clinical interview for DSM-IV-TR Axis I disorders, research version, patient edition (SCID-I/P) New York: Biometrics Research, New York State Psychiatric Institute; 2002.
    1. Gormally J, Black S, Daston S, Rardin D. The assessment of binge eating severity among obese persons. Addict Behav. 1982;7(1):47–55. doi: 10.1016/0306-4603(82)90024-7.
    1. Freitas S, Lopes CS, Coutinho W, Appolinario JC. Translation and adaptation into Portuguese of the binge-eating scale. Rev Bras Psiquiatr. 2001;23(4):215–220. doi: 10.1590/S1516-44462001000400008.
    1. Freitas SR, Lopes CS, Appolinario JC, Coutinho W. The assessment of binge eating disorder in obese women: a comparison of the binge eating scale with the structured clinical interview for the DSM-IV. Eat Behav. 2006;7(3):282–289. doi: 10.1016/j.eatbeh.2005.09.002.
    1. Allison KC, Crow SJ, Reeves RR, Foreyt JP, DiLillo VG, Wadden TA, et al. Binge eating disorder and night eating syndrome in adults with type 2 diabetes. Obesity. 2007;15:1287–1293. doi: 10.1038/oby.2007.150.
    1. American College of Endocrinology Consensus Statement on Guidelines for Glycemic Control* Endocr Pract. 2002;8(Suppl 1):5–11.
    1. Herpertz S, Albus C, Wagener R, Kocnar M, Henning A, Best F. Comorbidity of diabetes and eating disorders: does diabetes control reflect disturbed eating behavior? Diabetes Care. 1998;21(7):1.110–1.116. doi: 10.2337/diacare.21.7.1110.
    1. Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ. Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials. J Acad Nutr Diet. 2015;115(9):1447–1463. doi: 10.1016/j.jand.2015.02.031.
    1. Cohen RM, Lindsell CJ. When the blood glucose and the HbA1c don’t match: turning uncertainty into opportunity. Diabetes Care. 2012;35(12):2421–2423. doi: 10.2337/dc12-1479.
    1. Satya Krishna SV, Kota SK, Modi KD. Glycemic variability: clinical implications. Indian J Endocrinol Metab. 2013;17(4):611–619. doi: 10.4103/2230-8210.113751.

Source: PubMed

스폰서 및 공동 작업자

건강 상태

약물 개입

3
구독하다