Minocycline containing local drug delivery system in the management of chronic periodontitis: A randomized controlled trial

Ritu Jain, Faizuddin Mohamed, M Hemalatha, Ritu Jain, Faizuddin Mohamed, M Hemalatha

Abstract

Background: The role of chemotherapeutic agents in periodontal therapy as adjuncts to mechanical debridement maybe justified by the inherent limitations of mechanical therapy. The aim of this study was to evaluate the long term efficacy of a locally delivered 2% minocycline gel as an adjunct to scaling and root planing in managing chronic periodontitis.

Materials and methods: This was a randomized controlled trial using a split-mouth study design. Twenty two pairs of sites with similar probing depths were randomly allocated to test and control groups. All sites received thorough scaling and root planing followed by minocycline gel application in the test sites. Probing depths, relative attachment levels, plaque index, and microbiological parameters were evaluated for both the groups over a 9-month period.

Results: Overall parameters improved from baseline in both the test and control groups. For most parameters, the differences between test and control groups were not significant at different time intervals. The probing depth values in the test group at six (3.64±0.83 mm) and nine months (3.81±0.79 mm) were significantly less than control group(4.24±0.95 mm at six and 4.63±0.94 mm at nine months), these differences being significant at P<0.05 and <0.01, respectively. At the end of nine months, the number of non-motile bacilli in test group (21.65±3.74) were significantly less than control group (25.5±3.01), the difference being significant at P<0.02.

Conclusion: The overall view of results in our investigation did not show any significant advantage of using 2% minocycline gel over scaling and root planning as an effective local drug delivery system and calls for further clinical trials to objectively evaluate its adjunctive in treatment of periodontitis.

Keywords: Antimicrobial; biofilm; minocycline; periodontitis.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Root planing at test site
Figure 2
Figure 2
Placement of minocycline gel at the test site
Figure 3
Figure 3
Root planing at control site
Figure 4
Figure 4
Measuring the relative attachment level with plastic stent and endodontic spreader at test site
Figure 5
Figure 5
Measuring the relative attachment level at the control site
Figure 6
Figure 6
Depicting patients through various stages of the study
Figure 7
Figure 7
Depicting bleeding index values for test and control sites
Figure 8
Figure 8
Depicting probing depth values for treatment and control groups

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Source: PubMed

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