Effect of Sinus Floor Augmentation with Platelet-Rich Fibrin Versus Allogeneic Bone Graft on Stability of One-Stage Dental Implants: A Split-Mouth Randomized Clinical Trial

Aida Karagah, Reza Tabrizi, Parinaz Mohammadhosseinzade, Monirsadat Mirzadeh, Maryam Tofangchiha, Carlo Lajolo, Romeo Patini, Aida Karagah, Reza Tabrizi, Parinaz Mohammadhosseinzade, Monirsadat Mirzadeh, Maryam Tofangchiha, Carlo Lajolo, Romeo Patini

Abstract

Rehabilitation of an edentulous posterior maxilla with dental implants is challenging, and sinus floor augmentation could be considered as an important surgical procedure for bone augmentation in this region before implant placement. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with simplified processing: its application in sinus floor augmentation has been widely investigated in literature. However, the biological properties and actual efficacy of this product remain controversial. This study assessed the effect of sinus floor augmentation with PRF versus freeze-dried bone allograft (FDBA) on stability of one-stage dental implants. This split-mouth randomized clinical trial evaluated 10 patients who required bilateral sinus floor augmentation. PRF and L-PRF membrane were used in one quadrant while FDBA and collagen membrane were used in the other quadrant. Implant stability was assessed by resonance frequency analysis (RFA) immediately, and 2, 4, and 6 months after implant placement. The implant stability quotient (ISQ) was compared over time and between the two groups using repeated measures ANOVA and independent sample t-test. The mean ISQ significantly increased over time in both groups (p < 0.001). The increase was greater in the PRF group (p < 0.05). Within the limitations of this study, PRF yielded superior results compared with FDBA regarding the stability of one-stage dental implants.

Keywords: allograft; freeze-dried bone allograft; implant stability; platelet rich fibrin; sinus floor augmentation.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Trend of change in the mean ISQ over time in the two groups. As shown, the mean ISQ increased over time in both groups; however, this increase was greater in the PRF group.

References

    1. Öncü E., Alaaddinoğlu E.E. The effect of platelet-rich fibrin on implant stability. Int. J. Oral. Maxillofac. Implant. 2015;30:578–582. doi: 10.11607/jomi.3897.
    1. Chaushu L., Chaushu G., Better H., Naishlos S., Kolerman R., Aragoneses J.M., Calvo-Guirado J.L., Nissan J. Sinus augmentation with simultaneous, non-submerged, implant placement using a minimally invasive hydraulic technique. Medicina. 2020;56:75. doi: 10.3390/medicina56020075.
    1. Rahimi S.N., Ariff TT M., Affendi NH K., Ahmad R. Surface Modifications of Dental Implant and Its Clinical Performance: A Review. Compend. Oral Sci. 2022;9:52–66. doi: 10.24191/cos.v9i1.16907.
    1. Shapurian T., Damoulis P.D., Reiser G.M., Griffin T.J., Rand W.M. Quantitative evaluation of bone density using the Hounsfield index. Int. J. Oral Maxillofac Implants. 2006;21:290–297.
    1. Calandriello R., Tomatis M. Simplified treatment of the atrophic posterior maxilla via immediate/early function and tilted implants: A prospective 1-year clinical study. Clin. Implant. Dent. Relat. Res. 2005;7((Suppl. S1)):S1–S12. doi: 10.1111/j.1708-8208.2005.tb00069.x.
    1. Bathla S.C., Fry R.R., Majumdar K. Maxillary sinus floor augmentation. J. Indian Soc. Periodontol. 2018;22:468–473. doi: 10.4103/jisp.jisp_236_18.
    1. Baldi D., Menini M., Pera F., Ravera G., Pera P. Sinus floor elevation using osteotomes or piezoelectric surgery. Int. J. Oral Maxillofac. Surg. 2011;40:497–503. doi: 10.1016/j.ijom.2011.01.006.
    1. Cordaro L. Bilateral simultaneous augmentation of the maxillary sinus floor with particulated mandible. Report of a technique and preliminary results. Clin. Oral Implants. Res. 2003;14:201–206. doi: 10.1034/j.1600-0501.2003.140210.x.
    1. Boyne P.J., James R.A. Grafting of the maxillary sinus floor with autogenous marrow and bone. J. Oral Surg. 1980;38:613–616.
    1. Ortolani E., Guerriero M., Coli A., Di Giannuario A., Minniti G., Polimeni A. Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits. Ann. Stomatol. 2014;5:66–68. doi: 10.11138/ads/2014.5.2.066.
    1. He L., Lin Y., Hu X., Zhang Y., Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg. Oral Med. Oral Pathol Oral Radiol. Endod. 2009;108:707–713. doi: 10.1016/j.tripleo.2009.06.044.
    1. Dohan D.M., Choukroun J., Diss A., Dohan S.L., Dohan A.J., Mouhyi J., Gogly B. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med. Oral Pathol Oral Radiol Endod. 2006;101:e37–e44. doi: 10.1016/j.tripleo.2005.07.008.
    1. Silness J., Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and perio-dontal condition. Acta. Odontol. Scand. 1964;22:121–135. doi: 10.3109/00016356408993968.
    1. Tabrizi R., Arabion H., Karagah T. Does platelet-rich fibrin increase the stability of implants in the posterior of the maxilla? A split-mouth randomized clinical trial. Int. J. Oral Maxillofac. Surg. 2018;47:672–675. doi: 10.1016/j.ijom.2017.07.025.
    1. Miron R.J., Pikos M.A. Sinus floor augmentation Using Platelet-Rich Fibrin with or without a Bone Graft: What Is the Consensus? Compend. Contin. Educ. Dent. 2018;39:355–361.
    1. Wallace S.S., Froum S.J. Effect of maxillary sinus augmentation on the survival of endosseous dental implants. A systematic review. Ann. Periodontol. 2003;8:328–343. doi: 10.1902/annals.2003.8.1.328.
    1. Barbu H.M., Andreescu C.F., Comaneanu M.R., Referendaru D., Mijiritsky E. Maxillary Sinus Floor Augmentation to Enable One-Stage Implant Placement by Using Bovine Bone Substitute and Platelet-Rich Fibrin. Biomed. Res. Int. 2018;2018:6562958. doi: 10.1155/2018/6562958.
    1. Kokabi H. Radiographic comparison of density and height of posterior of maxillary bone after use of Open sinus lift with and without PRF. J. Adv. Periodontol. Implant. Dent. 2019;10:43–49.
    1. Clokie C.M., Bell R.C. Recombinant human transforming growth factor beta-1 and its effects on osseointegration. J. Craniofac. Surg. 2003;14:268–277. doi: 10.1097/00001665-200305000-00003.
    1. Cochran D.L., Schenk R., Buser D., Wozney J.M., Jones A.A. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J. Periodontol. 1999;70:139–150. doi: 10.1902/jop.1999.70.2.139.
    1. Choukroun J., Diss A., Simonpieri A., Girard M.O., Schoeffler C., Dohan S.L., Dohan A.J.J., Mouhyi J., Dohan D.M. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2006;101:299–303. doi: 10.1016/j.tripleo.2005.07.012.
    1. Raghoebar G.M., Schortinghuis J., Liem R.S., Ruben J.L., van der Wal J.E., Vissink A. Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor? Clin. Oral Implants. Res. 2005;16:349–356. doi: 10.1111/j.1600-0501.2005.01115.x.
    1. Tanaka H., Toyoshima T., Atsuta I., Ayukawa Y., Sasaki M., Matsushita Y., Iraoka R., Koyano K., Nakamura S. Additional Effects of Platelet-Rich Fibrin on Bone Regeneration in Sinus Augmentation with Deproteinized Bovine Bone Mineral: Preliminary Results. Implant. Dent. 2015;24:669–674. doi: 10.1097/ID.0000000000000306.
    1. Ali S., Bakry S.A., Abd-Elhakam H. Platelet-Rich Fibrin in Maxillary Sinus Augmentation: A Systematic Review. J. Oral Implantol. 2015;41:746–753. doi: 10.1563/AAID-JOI-D-14-00167.
    1. Mazor Z., Horowitz R.A., Del Corso M., Prasad H.S., Rohrer M.D., Dohan Ehrenfest D.M. Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: A radiologic and histologic study at 6 months. J. Periodontol. 2009;80:2056–2064. doi: 10.1902/jop.2009.090252.
    1. Simonpieri A., Choukroun J., Del Corso M., Sammartino G., Dohan Ehrenfest D.M. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: A six-year experience. Implant. Dent. 2011;20:2–12. doi: 10.1097/ID.0b013e3181faa8af.
    1. Tajima N., Ohba S., Sawase T., Asahina I. Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich fibrin as sole grafting material. Int. J. Oral Maxillofac. Implants. 2013;28:77–83. doi: 10.11607/jomi.2613.
    1. Aoki N., Kanayama T., Maeda M., Horii K., Miyamoto H., Wada K., Ojima Y., Tsuchimochi T., Shibuya Y. Sinus Augmentation by Platelet-Rich Fibrin Alone: A Report of Two Cases with Histological Examinations. Case Rep. Dent. 2016;2016:2654645. doi: 10.1155/2016/2654645.
    1. Ortega-Mejia H., Estrugo-Devesa A., Saka-Herrán C., Ayuso-Montero R., López-López J., Velasco-Ortega E. Platelet-Rich Plasma in Maxillary Sinus augmentation: Systematic Review. Materials. 2020;13:622. doi: 10.3390/ma13030622.
    1. Moy P.K., Medina D., Shetty V., Aghaloo T.L. Dental implant failure rates and associated risk factors. Int. J. Oral Maxillofac Implants. 2005;20:569–577.
    1. Porter J.A., von Fraunhofer J.A. Success or failure of dental implants? A literature review with treatment considerations. Gen. Dent. 2005;53:423–432.
    1. Torretta S., Mantovani M., Testori T., Cappadona M., Pignataro L. Importance of ENT assessment in stratifying candidates for sinus floor elevation: A prospective clinical study. Clin. Oral Implants Res. 2013;24((Suppl. SA100)):57–62. doi: 10.1111/j.1600-0501.2011.02371.x.
    1. Trieger N. Antibiotics and anti-inflammatory agents in dental implantology. Implant. Dent. 1999;8:343–346.
    1. Laskin D.M., Dent C.D., Morris H.F., Ochi S., Olson J.W. The influence of preoperative antibiotics on success of endosseous implants at 36 months. Ann. Periodontol. 2000;5:166–174. doi: 10.1902/annals.2000.5.1.166.
    1. Sharaf B., Dodson T.B. Does the use of prophylactic antibiotics decrease implant failure? Oral Maxillofac Surg Clin. N. Am. 2011;23:547–550. doi: 10.1016/j.coms.2011.07.008.
    1. Chirilă L., Rotaru C., Filipov I., Săndulescu M. Management of acute maxillary sinusitis after sinus bone grafting procedures with simultaneous dental implants placement-a retrospective study. BMC Infect. Dis. 2016;16((Suppl. S1)):94. doi: 10.1186/s12879-016-1398-1.
    1. Sennerby L. 20 Jahre Erfahrung mit der Resonanzfrequenzanalyse Sennerby L Prof, Sahlgrenska Academy, University of Gothenburg, Sweden. Implantologie. 2013;21:21–33. (In German)
    1. Bornstein M.M., Schmid B., Belser U.C., Lussi A., Buser D. Early loading of non-submerged titanium implants with a sandblasted and acid-etched surface. 5-year results of a prospective study in partially edentulous patients. Clin. Oral Implants. Res. 2005;16:631–638. doi: 10.1111/j.1600-0501.2005.01209.x.
    1. Elbaradie R., Ossman S., Eldibany R. Evaluation of platelet rich fibrin in sinus lifting with simultaneous implant placement. Alex. Dent. J. 2015;40:72–78. doi: 10.21608/adjalexu.2015.58739.

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