Evaluation of anorganic bovine-derived hydroxyapatite matrix/cell binding peptide as a bone graft material in the treatment of human periodontal infrabony defects: A clinico-radiographic study

Ghousia Fatima, Ravindra Shivamurthy, Srinath Thakur, Mohammad Abdul Baseer, Ghousia Fatima, Ravindra Shivamurthy, Srinath Thakur, Mohammad Abdul Baseer

Abstract

Background: Various bone graft materials have been used in the treatment of periodontal defects. A synthetic bone substitute material composed of P-15 with anorganic bone mineral has been scantly studied. Hence, the present study was aimed to evaluate and compare the efficacy of anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) in human periodontal infrabony defects with that of open flap debridement (OFD) alone.

Materials and methods: A split-mouth, randomized controlled clinical study was designed to investigate the efficacy of ABM/P-15. In this clinical trial, 10 patients having bilateral periodontal infrabony defects were treated either with ABM/P-15 or OFD and followed for a period of 9 months. At baseline and at 9 months probing pocket depth (PPD), relative attachment level (RAL), depth of a defect, and radiographic bone level were measured; and compared between test and control sites.

Results: A statistically significant reduction (P < 0.001) in PPD was observed in test sites compared to control sites. Both sites showed a gain in RAL without any significant difference. Similarly, the radiographic evaluation revealed significantly higher radiographic defect fill in test sites as compared to control sites (P < 0.001).

Conclusion: ABM/P-15 bone graft material appears to be useful and beneficial in the treatment of human periodontal infrabony defects.

Keywords: Cell binding peptide P-15; grafts; hydroxyapatite; periodontal disease; periodontal regeneration.

Figures

Figure 1
Figure 1
Probing pocket depth in test site at baseline
Figure 2
Figure 2
Relative attachment level in test site at baseline
Figure 3
Figure 3
Depth of the defect in test site at baseline
Figure 4
Figure 4
Radiograph in test site at baseline
Figure 5
Figure 5
Probing pocket depth in control site at baseline
Figure 6
Figure 6
Relative attachment level in control site at baseline
Figure 7
Figure 7
Depth of the defect in control site at baseline
Figure 8
Figure 8
Radiograph in control site at baseline
Figure 9
Figure 9
Placement of graft material in test site
Figure 10
Figure 10
Probing pocket depth in test site at 9 months
Figure 11
Figure 11
Relative attachment level in test site at 9 months
Figure 12
Figure 12
Depth of the defect in test site at 9 months
Figure 13
Figure 13
Radiograph in test site at 9 months
Figure 14
Figure 14
Probing pocket depth in control site at 9 months
Figure 15
Figure 15
Relative attachment level in control site at 9 months
Figure 16
Figure 16
Depth of the defect in control site at 9 months
Figure 17
Figure 17
Radiograph in control site at 9 months
Figure 18
Figure 18
Comparison of mean Radiographic Defect Fill between test and control sites
Figure 19
Figure 19
Changes in Clinical and Radiologic parameters in test and control sites at 9 months
Figure 20
Figure 20
Defect fill with graft particles in test site at 9 months

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