The efficacy of manual therapy and exercise for treating non-specific neck pain: A systematic review

Benjamin Hidalgo, Toby Hall, Jean Bossert, Axel Dugeny, Barbara Cagnie, Laurent Pitance, Benjamin Hidalgo, Toby Hall, Jean Bossert, Axel Dugeny, Barbara Cagnie, Laurent Pitance

Abstract

Objective: To review and update the evidence for different forms of manual therapy (MT) and exercise for patients with different stages of non-specific neck pain (NP).

Data sources: MEDLINE, Cochrane-Register-of-Controlled-Trials, PEDro, EMBASE.

Method: A qualitative systematic review covering a period from January 2000 to December 2015 was conducted according to updated-guidelines. Specific inclusion criteria only on RCTs were used; including differentiation according to stages of NP (acute - subacute [ASNP] or chronic [CNP]), as well as sub-classification based on type of MT interventions: MT1 (HVLA manipulation); MT2 (mobilization and/or soft-tissue-techniques); MT3 (MT1 + MT2); and MT4 (Mobilization-with-Movement). In each sub-category, MT could be combined or not with exercise and/or usual medical care.

Results: Initially 121 studies were identified for potential inclusion. Based on qualitative and quantitative evaluation criteria, 23 RCTs were identified for review. Evidence for ASNP: MODERATE-evidence: In favour of (i) MT1 to the cervical spine (Cx) combined with exercises when compared to MT1 to the thoracic spine (Tx) combined with exercises; (ii) MT3 to the Cx and Tx combined with exercise compared to MT2 to the Cx with exercise or compared to usual medical care for pain and satisfaction with care from short to long-term. Evidence for CNP: STRONG-evidence: Of no difference of efficacy between MT2 at the symptomatic Cx level(s) in comparison to MT2 on asymptomatic Cx level(s) for pain and function. MODERATE to STRONG-evidence: In favour of MT1 and MT3 on Cx and Tx with exercise in comparison to exercise or MT alone for pain, function, satisfaction with care and general-health from short to moderate-terms. MODERATE-evidence: In favour (i) of MT1 as compared to MT2 and MT4, all applied to the Cx, for neck mobility, and pain in the very short term; (ii) of MT2 using sof-tissue-techniques to the Cx and Tx or MT3 to the Cx and Tx in comparison to no-treatment in the short-term for pain and disability.

Conclusion: This systematic review updates the evidence for MT combined or not with exercise and/or usual medical care for different stages of NP and provides recommendations for future studies. Two majors points could be highlighted, the first one is that combining different forms of MT with exercise is better than MT or exercise alone, and the second one is that mobilization need not be applied at the symptomatic level(s) for improvements of NP patients. These both points may have clinical implications for reducing the risk involved with some MT techniques applied to the cervical spine.

Keywords: Manual Therapy; evidence based practice; exercise; musculoskeletal manipulation; neck pain; systematic review.

Conflict of interest statement

None to report.

Figures

Figure 1.
Figure 1.
PRISMA flowchart of inclusion.

References

    1. Gonzalez-Iglesias J, Fernandez-de-las-Penas C, Cleland JA, Alburquerque-Sendin F, Palomeque-del-Cerro L, Mendez-Sanchez R. Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: A randomized clinical trial. Man Ther 2009; 14: 306-13.
    1. Cleland JA, Glynn P, Whitman JW, Eberhart SL, MacDonald C, Childs JD. Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the thoracic spine in patients with neck pain: A randomized clinical trial. Phys Ther 2007; 87: 431-40.
    1. Jette AM, Smith K, Haley SM, Davis KD. Physical therapy episodes of care for patients with low back pain. Phys Ther 1994; 74: 101-10.
    1. Vincent K, Maigne JY, Fischhoff C, Lanlo O, Dagenais S. Systematic review of manual therapies for nonspecific neck pain. Joint Bone Spine 2013; 80: 508-15.
    1. Sherman KJ, Cherkin DC, Hawkes RJ, Miglioretti DL, Deyo RA. Randomized trial of therapeutic massage for chronic neck pain. Clin J Pain 2009; 25: 233-8.
    1. Evans R, Bronfort G, Nelson B, Goldsmith CH. Two-year follow-up of a randomized clinical trial of spinal manipulation and two types of exercise for patients with chronic neck pain. Spine 2002; 27: 2383-89.
    1. Bronfort G, Evans R, Nelson B, Aker PD, Goldsmith CH, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine 2001; 26: 788-97.
    1. Lau HMC, Wing TT, Lam TH. The effectiveness of thoracic manipulation on patients with chronic mechanical neck pain – A randomized controlled trial. Man Ther 2011; 16: 141-7.
    1. Haldeman S, Carroll L, Cassidy JD, Schubert J, Nygren A, et al. The bone and joint decade 2000-2010 task force on neck pain and its associated disorders: Executive summary. Spine 2008; 33: 5-7.
    1. Madson TJ, Cieslak KR, Gay RE. Joint mobilization vs massage for chronic mechanical neck pain: A pilot study to assess recruitment strategies and estimate outcome measure variability. J Manipulative Physiol Ther 2010; 33: 644-51.
    1. Schwerla F, Bischoff A, Nurnberger A, Genter P, Guillaume JP, Resch KL. Osteopathic treatment of patients with chronic non-specific neck pain: A randomised controlled trial of efficacy. Forsch Komplementmed 2008; 15: 138-45.
    1. Hemmila HM. Bone setting for prolonged neck pain: A randomized clinical trial. J Manipulative Physiol Ther 2005; 28: 508-15.
    1. Palmgren PJ, Sandstrom PJ, Lundqvist FJ, Heikkila H. Improvement after chiropractic care in cervicocephalic kinesthetic sensibility and subjective pain intensity in patients with nontraumatic chronic neck pain. J Manipulative Physiol Ther 2006; 29: 100-6.
    1. Dziedzic K, Hill J, Lewis M, Sim J, Daniels J, Hay EM. Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders: A pragmatic randomized controlled trial in physical therapy clinics. Arthritis Rheum 2005; 53: 214-22.
    1. Nagrale AV, Glynn P, Joshi A, Ramteke G. The efficacy of an integrated neuromuscular inhibition technique on upper trapezius trigger points in subjects with non-specific neck pain: A randomized controlled trial. J Man Manip Ther 2010; 18: 37-43.
    1. Pool JJ, Ostelo RW, Knol DL, Vlaeyen JW, Bouter LM, de Vet HC. Is a behavioral graded activity program more effective than manual therapy in patients with subacute neck pain? Results of a randomized clinical trial. Spine 2010; 35: 1017-24.
    1. Martel J, Dugas C, Dubois JD, Descarreaux M. A randomised controlled trial of preventive spinal manipulation with and without a home exercise program for patients with chronic neck pain. BMC Musculoskelet Disord 2011; 12: 41-49.
    1. Cleland JA, Childs JD, McRae M, Palmer JA, Stowell T. Immediate effects of thoracic manipulation in patients with neck pain: A randomized clinical trial. Man Ther 2005; 10: 127-35.
    1. Aquino RL, Caires PM, Furtado FC, Loureiro AV, Ferreira PH, Ferreira ML. Applying joint mobilization at different cervical vertebral levels does not influence immediate pain reduction in patients with chronic neck pain: A randomized clinical trial. J Man Manip Ther 2009; 17: 95-100.
    1. Hidalgo B. Detrembleur C, Hall T, Mahaudens P, Nielens H. The efficacy of manual therapy and exercise for different stages of non-specific low back pain: An update of systematic reviews. J Man Manip Ther 2014; 22: 59-74.
    1. Konstantinou K, Foster N, Rushton A, Baxter D. The use and reported effects of mobilization with movement techniques in low back pain management; a cross-sectional descriptive survey of physiotherapists in Britain. Man Ther 2002; 7: 206-14.
    1. Hidalgo B, Pitance L, Hall T, Detrembleur C, Nielens H. Short-term effects of Mulligan mobilization with movement on pain, disability, and kinematic spinal movements in patients with nonspecific low back pain: A randomized placebo-controlled trial. J Manipulative Physiol Ther 2015; 38: 365-74.
    1. Miller J, Gross A, D’Sylva J, Burnie SJ, Goldsmith CH, Graham N, et al. Manual therapy and exercise for neck pain: A systematic review. Man Ther 2010; 15: 334-354.
    1. van Tulder MW, Furlan AD, Bombardier C, Bouter L. Update method guidelines for systematic reviews in the cochrane collaboration back review group. Spine 2003; 28: 1290-9.
    1. Ganesh GS, Mohanty P, Pattnaik M, Mishra C. Effectiveness of mobilization therapy and exercises in mechanical neck pain. Physiother Theory Pract 2015; 31: 99-106.
    1. Leininger BD, Evans R, Bronfort G. Exploring patient satisfaction: A secondary analysis of a randomized clinical trial of spinal manipulation, home exercise, and medication for acute and subacute neck pain. J Manipulative Physiol Ther 2014; 37: 593-601.
    1. Akhter S, Khan M, Ali SS, Soomro RR. Role of manual therapy with exercise regime versus exercise regime alone in the management of non-specific chronic neck pain. Pak J Pharm Sci 2014; 27: 2125-8.
    1. Lopez-Lopez A, Alonso Perez JL, González Gutierez JL, La Touche R, Lerma Lara S, et al. Mobilization versus manipulations versus sustain apophyseal natural glide techniques and interaction with psychological factors for patients with chronic neck pain: Randomized controlled trial. Eur J Phys Rehabil Med 2015; 51: 121-32.
    1. Beltran-Alacreu H, López-de-Uralde-Villanueva I, Fernández -Carnero J, La Touche R. Manual therapy, therapeutic patient education, and therapeutic exercise, an effective multimodal treatment of nonspecific chronic neck pain: A randomized controlled trial. Am J Phys Med Rehabil 2015; 94: 887-97.
    1. Furlan AD, Malmivaara A, Chou R, Maher CG, Deyo RA, Schoene M, et al. Updated method guideline for systematic reviews in the cochrane back and neck group. Spine 2015; 40: 1660-73.
    1. Guzman J, Hurwitz EL, Carroll LJ, Haldeman S, Cote P, Carragee EJ, et al. A new conceptual model of neck pain: Linking onset, course, and care: The bone and joint decade 2000-2010 task force on neck pain and its associated disorders. Spine 2008; 33: 14-23.
    1. Bronfort G, Haas M, Evans RL, Bouter LM. Efficacy of spinal manipulation and mobilization for low back pain and neck pain: A systematic review and best evidence synthesis. Spine J 2004; 4: 335-56.
    1. Cleland JA, Fritz JM, Kulig K, Davenport TE, Eberhart S, Magel J, et al. Comparison of the effectiveness of three manual physical therapy techniques in a subgroup of patients with low back pain who satisfy a clinical prediction rule: A randomized clinical trial. Spine 2009; 34: 2720-9.
    1. Di Fabio RP. Efficacy of manual therapy. Phys Ther 1992; 72: 853-64.
    1. Bronfort G. Spinal manipulation: Current state of research and its indications. Neurol Clin 1999; 17: 91-111.
    1. Mulligan B. “Nags”, “Snags”, “MWMS” etc. 4 ed. Welligton, New Zealand: Plane View Services Ltd; 1999.
    1. Hing W, Hall T, Rivett D, Vicenzino B, Mulligan B. The mulligan concept of manual therapy. Elsevier, Australia 2015; 1-489.
    1. Demoulin C, Depas Y, Vanderthommen M, Henrotin Y, Wolfs S, Cagnie B, Hidalgo B. Orthopaedic manual therapy: Definition, characteristics and update on the situation in Belgium. Rev Med Liège 2017; 72: 126-31.
    1. Niemisto L, Lahtinen-Suopanki T, Rissanen P, Lindgren KA, Sarna S, Hurri H. A randomized trial of combined manipulation, stabilizing exercises, and physician consultation compared to physician consultation alone for chronic low back pain. Spine 2003; 28: 2185-91.
    1. Kent P, Mjosund HL, Petersen DH. Does targeting manual therapy and/or exercise improve patient outcomes in nonspecific low back pain? A systematic review. BMC Med 2010; 8(22): 1-15.
    1. Waddell G, Phillips RB. The back pain revolution. In: Churchill Livingstone Edinburgh 2000; 1-480.
    1. Puentedura EJ, Landers MR, Cleland JA, Mintken PE, Huijbregts P, Fernandez-de-Las-Penas C. Thoracic spine thrust manipulation versus cervical spine thrust manipulation in patients with acute neck pain: A randomized clinical trial. J Orthop Sports Phys Ther 2011; 41: 208-20.
    1. Gonzalez-Iglesias J, Fernandez-de-las-Penas C, Cleland JA, Gutierrez-Vega R. Thoracic spine manipulation for the management of patients with neck pain: A randomized clinical trial. J Orthop Sports Phys Ther 2009; 39: 20-7.
    1. Blikstad A, Gemmell H. Immediate effect of activator trigger point therapy and myofascial band therapy on non-specific neck pain in patients with upper trapezius trigger points compared to sham ultrasound: A randomised controlled trial. Clinical Chiropractic 2008; 11: 23-29.
    1. Gemmell H, Miller P, Nordstrom H. Immediate effect of ischaemic compression and trigger point pressure release on neck pain and upper trapezius trigger points: A randomised controlled trial. Clinical Chiropractic 2008; 11: 30-36.
    1. Bronfort G, Evans R, Anderson AV, Svendsen KH, Bracha Y, Grimm RH. Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: A randomized trial. Ann Intern Med 2012; 156: 1-10.
    1. Cherkin DC, Deyo RA, Street JH, Hunt M, Barlow W. Pitfalls of patient education. Limited success of a pogam fo back pain in primary care. Spine 1996; 21: 345-55.
    1. Masaracchio M, Cleland JA, Hellman M, Hagins M. Short-term combined effects of thoracic spine thrust manipulation and cervical spine nonthrust manipulation in individuals with mechanical neck pain: A randomized clinical trial. J Orthop Sports Phys Ther 2013; 43: 118-27.
    1. Izquierdo Perez H, Alonso Perez JL, Gil Martinez A, La Touche R, Lerma-Lara S, Commeaux Gonzalez N, et al. Is one better than another? A randomized clinical trial of manual therapy for patients with chronic neck pain. Man Ther 2014; 19: 215-21.
    1. Lopez-Lopez A, Alonso Perez JL, Gonzalez Gutierez JL, La Touche R, Lerma Lara S, Izquierdo H, et al. Mobilization versus manipulations versus sustain appophyseal natural glide techniques and interaction with psychological factors for patients with chronic neck pain: Randomized control Trial. Eur J Phys Rehabil Med 2015; 51: 121-32.
    1. Saavedra-Hernandez M, Castro-Sanchez AM, Arroyo-Morales M, Cleland JA, Lara-Palomo IC, Fernandez-de-Las-Penas C. Short-term effects of kinesio taping versus cervical thrust manipulation in patients with mechanical neck pain: A randomized clinical trial. J Orthop Sports Phys Ther 2012; 42: 724-30.
    1. Martinez-Segura R, De-la-Lave-Rincon AI, Ortega-Santiago R, Cleland JA, Fernandez-de-Las-Penas C. Immediate changes in widespread pressure pain sensitivity, neck pain, and cervical range of motion after cervical or thoracic thrust manipulation in patients with bilateral chronic mechanical neck pain: A randomized clinical trial. J Orthop Sports Phys Ther 2012; 42: 806-14.
    1. Kanlayanaphotporn R, Chiradejnant A, Vachalathiti R. The immediate effects of mobilization technique on pain and range of motion in patients presenting with unilateral neck pain: A randomized controlled trial. Arch Phys Med Rehabil 2009; 90: 187-92.
    1. Schomacher J. The effect of an analgesic mobilization technique when applied at symptomatic or asymptomatic levels of the cervical spine in subjects with neck pain: A randomized controlled trial. J Man Manip Ther 2009; 17: 101-8.
    1. Evans R, Bronfort G, Schulz C, Maiers M, Bracha Y, Svendsen K, et al. Supervised exercise with and without spinal manipulation performs similarly and better than home exercise for chronic neck pain: A randomized controlled trial. Spine 2012; 37: 903-14.
    1. Gross A, Miller J, D’Sylva J, Burnie SJ, Goldsmith CH, Graham N, et al. Manipulation or mobilisation for neck pain: A Cochrane Review. Man Ther 2010; 15: 315-33.
    1. Hurwitz EL, Morgenstern H, Vassilaki M, Chiang LM. Adverse reactions to chiropractic treatment and their effects on satisfaction and clinical outcomes among patients enrolled in the UCLA Neck Pain Study. J Manipulative Physiol Ther 2004; 27: 16-25.
    1. Carnes D, Mars TS, Mullinger B, Froud R, Underwood M. Adverse events and manual therapy: A systematic review. Man Ther 2010; 15: 355-63.
    1. Cagnie B, Vinck E, Beernaert A, Cambier D. How common are side effects of spinal manipulation and can these side effects be predicted? Man Ther 2004; 9: 151-6.
    1. Paanalahti K, Holm LW, Nordin M, Asker M, Lyander J, Skillgate E. Adverse events after manual therapy among patients seeking care for neck and/or back pain: A randomized controlled trial. BMC Musculoskelet Disord 2014; 15: 77.
    1. Thomas LC, Rivett DA, Attia JR, Levi CR. Risk factors and clinical presentation of craniocervical arterial dissection: A prospective study. BMC Musculoskelet Disord 2012; 13: 164.
    1. Kerry R, Taylor AJ, Mitchell J, McCarthy C, Brew J. Manual therapy and cervical arterial dysfunction, directions for the future: A clinical perspective. J Man Manip Ther 2008; 16: 39-48.
    1. Cassidy JD, Bronfort G, Hartvigsen J. Should we abandon cervical spine manipulation for mechanical neck pain? No. BMJ 2012; 344: 3680.
    1. Wand BM, Heine PJ, O’Connell NE. Should we abandon cervical spine manipulation for mechanical neck pain? Yes. BMJ 2012; 344: 3679.
    1. Haldeman S, Kohlbeck FJ, McGregor M. Stroke, cerebral artery dissection, and cervical spine manipulation therapy. J Neurol 2002; 249: 1098-104.
    1. Thomas LC. Cervical arterial dissection: An overview and implications for manipulative therapy practice. Man Ther 2016. Feb; 21: 2-9.
    1. Ford JJ, Hahne AJ. Complexity in the physiotherapy management of low back disorders: Clinical and research implications. Man Ther 2013; 18: 438-42.
    1. Foster NE, Hill JC, O’Sullivan P, Hancock M. Stratified models of care. Best Pract Res Clin Rheumatol 2013; 27: 649-61.
    1. Dewitte V, Beernaert A, Vanthillo B, Barbe T, Danneels L, Cagnie B. Articular dysfunction patterns in patients with mechanical neck pain: A clinical algorithm to guide specific mobilization and manipulation techniques. Man Ther 2014; 19: 2-9.
    1. Jones M, Edwards I, Gifford L. Conceptual models for implementing biopsychosocial theory in clinical practice. Man Ther 2002; 7: 2-9.
    1. Hidalgo B. Evidence based orthopaedic manual therapy for patients with non-secific low back pain: An integrative approach. J Back Musculoskelet Rehabil 2016; 29: 231-9.
    1. Llamas-Ramos R, Pecos-Martin D, Gallego-Izquierdo T, Llamas-Ramos I, Plaza-Manzano G, Ortega-SantiagoR, et al. Comparison of the short-term outcomes between trigger point dry needling and trigger point manual therapy for the management of chronic mechanical neck pain: a randomized clinical trial. J Orthop Sports Phys Ther 2014; 44: 852-61.
    1. Madson TJ., Cieslak KR., Gay RE., Joint mobilization vs massage for chronic mechanical neck pain: a pilot study to assess recruitment strategies and estimate outcome measure variability, J Manipulative Physiol Ther 2010; 33: 644-51.
    1. Salom-Moreno J, Ortega-Santiago R, Cleland JA, Palacios-Cena M, Truyols-Dominguez S, Fernandez-de-las-Penas C. Immediate changes in neck pain intensity and widespread pressure pain sensitivity in patients with bilateral chronic mechanical neck pain: a randomized controlled trial of thoracic thrust manipulation vs non-thrust mobilization. J Manipulative Physiol Ther 2014; 37: 312-9.
    1. Leaver AM., Maher CG., Herbert RD., Latimer J., McAuley JH., Jull G., et al.A randomized controlled trial comparing manipulation with mobilization for recent onset neck pain, Arch Phys Med Rehabil 2010; 91: 1313-8.
    1. Saavedra-Hernandez M., Arroyo-Morales M., Cantarero-Villanueva I., Fernandez-Lao C., Castro-Sanchez AM., Puentedura EJ., et al.Short-term effects of spinal thrust joint manipulation in patients with chronic neck pain: a randomized clinical trial, Clin Rehabil 2013; 27: 504-12.
    1. Cleland JA, Glynn P, Whitman JM, Eberhart SL, MacDonald C, Childs JD. Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the thoracic spine in patients with neck pain: a randomized clinical trial. Phys Ther 2007; 87: 431-40.
    1. Suvarnnato T., Puntumetakul R., Kaber D., Boucaut R., Boonphakob Y., Arayawichanon P., et al.The effects of thoracic manipulation versus mobilization for chronic neck pain: a randomized controlled trial pilot study, J Phys Ther Sci 2013; 25: 865-71.
    1. Dziedzic K., Hill J., Lewis M., Sim J., Daniels J., Hay EM., Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders: a pragmatic randomized controlled trial in physical therapy clinics, Arthritis Rheum 2005; 53: 214-22.
    1. Saayman L., Hay C., Abrahamse H., Chiropractic manipulative therapy and low-level laser therapy in the management of cervical facet dysfunction: a randomized controlled study, J Manipulative Physiol Ther 2011; 34: 153-63.
    1. Zaproudina N., Hanninen OO., Airaksinen O., Effectiveness of traditional bone setting in chronic neck pain: randomized clinical trial, J Manipulative Physiol Ther 2007; 30: 432-7.
    1. Snodgrass SJ., Rivett DA., Sterling M., Vicenzino B., Dose optimization for spinal treatment effectiveness: a randomized controlled trial investigating the effects of high and low mobilization forces in patients with neck pain, J Orthop Sports Phys Ther 2014; 44: 141-52.
    1. Ylinen J., Kautiainen H., Wiren K., Hakkinen A., Stretching exercises vs manual therapy in treatment of chronic neck pain: a randomized, controlled cross-over trial. J Rehabil Med 2007; 39: 126-32.
    1. Lluch E., Schomacher J., Gizzi L., Petzke F., Seegar D., Falla D., Immediate effects of active cranio-cervical flexion exercise versus passive mobilisation of the upper cervical spine on pain and performance on the cranio-cervical flexion test, Man Ther 2014; 19: 25-31.
    1. Martinez-Segura R., Fernandez-de-las-Penas C, Ruiz-Saez M, Lopez-Jimenez C, Rodriguez-Blanco C. Immediate effects on neck pain and active range of motion after a single cervical high-velocity low-amplitude manipulation in subjects presenting with mechanical neck pain: a randomized controlled trial. J Manipulative Physiol Ther 2006; 29: 511-7.
    1. Vernon H., Triano JT., Soave D., Dinulos M., Ross K., Tran S., Retention of blinding at follow-up in a randomized clinical study using a sham-control cervical manipulation procedure for neck pain: secondary analyses from a randomized clinical study, J Manipulative Physiol Ther 2013; 36: 522-6.
    1. Hoving JL, de Vet HC, Koes BW, Mameren H, Deville WL, van der Windt DA, et al. Manual therapy, physical therapy, or continued care by the general practitioner for patients with neck pain: long-term results from a pragmatic randomized clinical trial. Clin J Pain 2006: 22: 370-7.
    1. Dunning JR, Cleland JA, Waldrop MA, Arnot CF, Young IA, Turner M, et al. Upper cervical and upper thoracic thrust manipulation versus nonthrust mobilization in patients with mechanical neck pain: a multicenter randomized clinical trial. J Orthop Sports Phys Ther 2012; 42: 5-18.
    1. Palmgren PJ., Sandstrom PJ., Lundqvist FJ., Heikkila H., Improvement after chiropractic care in cervicocephalic kinesthetic sensibility and subjective pain intensity in patients with nontraumatic chronic neck pain, J Manipulative Physiol Ther 2006; 29: 100-6.
    1. Martel J., Dugas C., Dubois JD., Descarreaux M., A randomised controlled trial of preventive spinal manipulation with and without a home exercise program for patients with chronic neck pain, BMC Musculoskelet Disord 2011; 12: 41.
    1. Cleland JA, Childs JD, McRae M, Palmer JA, Stowell T. Immediate effects of thoracic manipulation in patients with neck pain: a randomized clinical trial. Man Ther 2005; 10: 127-35.
    1. Escortell-Mayor E., Riesgo-Fuertes R., Garrido-Elustondo S., Asunsolo-Del Barco A., Diaz-Pulido B., Blanco-Diaz M., et al.Primary care randomized clinical trial: manual therapy effectiveness in comparison with TENS in patients with neck pain, Man Ther 2011; 16: 66-73.
    1. McReynolds TM., Sheridan BJ., Intramuscular ketorolac versus osteopathic manipulative treatment in the management of acute neck pain in the emergency department: a randomized clinical trial, J Am Osteopath Assoc 2005; 105: 57-68.
    1. Boyles RE., Walker MJ., Young BA., Strunce J., Wainner RS., The addition of cervical thrust manipulations to a manual physical therapy approach in patients treated for mechanical neck pain: a secondary analysis, J Orthop Sports Phys Ther 2010; 40: 133-40.
    1. Evans R., Bronfort G., Bittell S., Anderson AV., A pilot study for a randomized clinical trial assessing chiropractic care, medical care, and self-care education for acute and subacute neck pain patients. J Manipulative Physiol Ther 2003; 26: 403-11.
    1. Groeneweg R, Kropman H, Leopold H, van Assen L, Mulder J. van Tulder MW, et al. The effectiveness and cost-evaluation of manual therapy and physical therapy in patients with sub-acute and chronic non specific neck pain. Rationale and design of a Randomized Controlled Trial (RCT). BMC Musculoskelet Disord 2010; 11: 14.
    1. Hurwitz EL., Morgenstern H., Harber P., Kominski GF., Yu,F., Adams AH., A randomized trial of chiropractic manipulation and mobilization for patients with neck pain: clinical outcomes from the UCLA neck-pain study, Am J Public Health 2002; 92: 1634-41.
    1. Kanlayanaphotporn R., Chiradejnant A., Vachalathiti R., Immediate effects of the central posteroanterior mobilization technique on pain and range of motion in patients with mechanical neck pain, Disabil Rehabil 2010; 32: 622-8.
    1. Hoving JL, Koes BW, de Vet HC, van der Windt DA, Assendelft WJ, van Mameren H, et al. Manual therapy, physical therapy, or continued care by a general practitioner for patients with neck pain. A randomized, controlled trial. Ann Intern Med 2002; 136: 713-22.
    1. Mansilla-Ferragut P., Fernandez-de-Las Penas C, Alburquerque-Sendin F, Cleland JA, Bosca-Gandia JJ. Immediate effects of atlanto-occipital joint manipulation on active mouth opening and pressure pain sensitivity in women with mechanical neck pain. J Manipulative Physiol Ther 2009; 32: 101-6.
    1. Wood TG., Colloca CJ., Matthews R., A pilot randomized clinical trial on the relative effect of instrumental (MFMA) versus manual (HVLA) manipulation in the treatment of cervical spine dysfunction, J Manipulative Physiol Ther 2001; 24: 260-71.
    1. Strunk RG., Hondras MA., A feasibility study assessing manual therapies to different regions of the spine for patients with subacute or chronic neck pain, J Chiropr Med 2008; 7: 1-8.
    1. van Schalkwyk R., Parkin-Smith GF., A clinical trial investigating the possible effect of the supine cervical rotatory manipulation and the supine lateral break manipulation in the treatment of mechanical neck pain: a pilot study, J Manipulative Physiol Ther 2000; 23: 324-31.
    1. Walker MJ., Boyles RE., Young BA., Strunce JB., Garber MB., Whitman JM., et al.The effectiveness of manual physical therapy and exercise for mechanical neck pain: a randomized clinical trial, Spine 2008; 33: 2371-8.
    1. Hanten WP., Olson SL., Butts NL., Nowicki AL., Effectiveness of a home program of ischemic pressure followed by sustained stretch for treatment of myofascial trigger points, Phys Ther 2000; 80: 997-1003.
    1. Hakkinen A., Salo P., Tarvainen U., Wiren K., Ylinen J., Effect of manual therapy and stretching on neck muscle strength and mobility in chronic neck pain, J Rehabil Med 2007; 39: 575-9.
    1. Ali A., Shakil-ur-Rehman S., Sibtain F., The efficacy of sustained natural apophyseal glides with and without isometric exercise training in non-specific neck pain, Pak J Med Sci 2014; 30: 872-4.
    1. Beltran-Alacreu H., Lopez-de-Uralde-Villanueva I, Fernandez-Carnero J, La Touche R. Manual therapy, therapeutic patient education, and therapeutic exercise, an effective multimodal treatment of nonspecific chronic neck pain. Am J Phys Med Rehabil 2015; 10: 887-97.

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