Absorption, pharmacokinetics, and safety of triclosan after dermal administration
Christian Queckenberg, Jürgen Meins, Bertil Wachall, Oxana Doroshyenko, Dorota Tomalik-Scharte, Bärbel Bastian, Mona Abdel-Tawab, Uwe Fuhr, Christian Queckenberg, Jürgen Meins, Bertil Wachall, Oxana Doroshyenko, Dorota Tomalik-Scharte, Bärbel Bastian, Mona Abdel-Tawab, Uwe Fuhr
Abstract
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.
Source: PubMed