Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
Naomi N Hunder, Herschel Wallen, Jianhong Cao, Deborah W Hendricks, John Z Reilly, Rebecca Rodmyre, Achim Jungbluth, Sacha Gnjatic, John A Thompson, Cassian Yee, Naomi N Hunder, Herschel Wallen, Jianhong Cao, Deborah W Hendricks, John Z Reilly, Rebecca Rodmyre, Achim Jungbluth, Sacha Gnjatic, John A Thompson, Cassian Yee
Abstract
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
Conflict of interest statement
No potential conflict of interest relevant to this article was reported.
2008 Massachusetts Medical Society
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Source: PubMed