IDENTIFY: The investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer: A multicentre cohort study

Sinan Khadhouri, Kevin M Gallagher, Kenneth MacKenzie, Taimur T Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Graeme MacLennan, John S McGrath, Veeru Kasivisvanathan, IDENTIFY Protocol Collaborators Group, Hashim Ahmed, Jon Deeks, Mark Emberton, Jeevan Kumaradeevan, Susan Mallett, Yemisi Takwoingi, Steve Morris, Allen Knight, Chris Blick, James Catto, Daniel Cohen, James Green, John Kelly, Hugh Mostafid, Sinan Khadhouri, Kevin M Gallagher, Kenneth MacKenzie, Taimur T Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Graeme MacLennan, John S McGrath, Veeru Kasivisvanathan, IDENTIFY Protocol Collaborators Group, Hashim Ahmed, Jon Deeks, Mark Emberton, Jeevan Kumaradeevan, Susan Mallett, Yemisi Takwoingi, Steve Morris, Allen Knight, Chris Blick, James Catto, Daniel Cohen, James Green, John Kelly, Hugh Mostafid

Abstract

•IDENTIFY study: The largest prospective cohort study of haematuria in secondary care.•Contemporary urinary cancer detection rates and diagnostic strategies.•The effectiveness of diagnostic tests, e.g. ultrasound, in detecting urinary cancer.•Novel patient risk factors associated with bladder and upper tract urinary cancers.

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

© 2020 The Authors.

Figures

Fig. 1
Fig. 1
Typical pathway for a patient referred with suspected urinary tract cancer.

References

    1. Antoni S., Ferlay J., Soerjomataram I., Znaor A., Jemal A., Bray F. Bladder cancer incidence and mortality: a global overview and recent trends. Eur. Urol. 2017;71:96–108. doi: 10.1016/j.eururo.2016.06.010.
    1. Bladder cancer survival statistics | Cancer Research UK, (n.d.). (accessed November 19, 2019).
    1. Babjuk M., Böhle A., Burger M., Capoun O., Cohen D., Compérat E.M., Hernández V., Kaasinen E., Palou J., Rouprêt M., van Rhijn B.W.G., Shariat S.F., Soukup V., Sylvester R.J., Zigeuner R. EAU guidelines on non–muscle-invasive urothelial carcinoma of the bladder: Update. Eur. Urol. 2016;71(2017):447–461. doi: 10.1016/j.eururo.2016.05.041.
    1. Chang S.S., Boorjian S.A., Chou R., Clark P.E., Daneshmand S., Konety B.R., Pruthi R., Quale D.Z., Ritch C.R., Seigne J.D., Skinner E.C., Smith N.D., McKiernan J.M. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO guideline. J. Urol. 2016;196:1021–1029. doi: 10.1016/j.juro.2016.06.049.
    1. Edwards T.J., Dickinson A.J., Natale S., Gosling J., McGrath J.S. A prospective analysis of the diagnostic yield resulting from the attendance of 4020 patients at a protocol-driven haematuria clinic. BJU Int. 2006;97:301–305. doi: 10.1111/j.1464-410X.2006.05976.x.
    1. Khadra M.H., Pickard R.S., Charlton M., Powell P.H., Neal D.E. A prospective analysis of 1,930 patients with hematuria to evaluate current diagnostic practice. J. Urol. 2000;163:524–527. doi: 10.1016/S0022-5347(05)67916-5.
    1. Yecies T., Bandari J., Fam M., Macleod L., Jacobs B., Davies B. Risk of radiation from computerized tomography urography in the evaluation of asymptomatic microscopic hematuria. J. Urol. 2018;200:967–972. doi: 10.1016/j.juro.2018.05.118.
    1. Wheelan P W.D., Taylor M. Economic burden of bladder cancer in the UK. BJU Int. 2008;101(35) doi: 10.1111/j.1464-410X.2008.07685.x.
    1. Suspected cancer: recognition and referral | NICE Guidance [NG12], NICE, London, 2015. (accessed September 3, 2019).
    1. Davis R., Jones J.S., Barocas D.A., Castle E.P., Lang E.K., Leveillee R.J., Messing E.M., Miller S.D., Peterson A.C., Turk T.M.T., Weitzel W. Diagnosis, evaluation and follow-up of asymptomatic microhematuria (AMH) in adults: AUA guideline. J. Urol. 2012;188:2473–2481. doi: 10.1016/j.juro.2012.09.078.
    1. Rodgers M.A., Hempel S., Aho T., Kelly J.D., Kleijnen J., Westwood M. Diagnostic tests used in the investigation of adult haematuria: A systematic review. BJU Int. 2006;98:1154–1160. doi: 10.1111/j.1464-410X.2006.06406.x.
    1. Blick C.G.T., Nazir S.A., Mallett S., Turney B.W., Onwu N.N., Roberts I.S.D., Crew J.P., Cowan N.C. Evaluation of diagnostic strategies for bladder cancer using computed tomography (CT) urography, flexible cystoscopy and voided urine cytology: Results for 778 patients from a hospital haematuria clinic. BJU Int. 2012;110:84–94. doi: 10.1111/j.1464-410X.2011.10664.x.
    1. Georgieva M.V., Wheeler S.B., Erim D., Smith-Bindman R., Loo R., Ng C., Garg T., Raynor M., Nielsen M.E. Comparison of the Harms, advantages, and costs associated with alternative guidelines for the evaluation of hematuria. JAMA Intern. Med. 2019 doi: 10.1001/jamainternmed.2019.2280.
    1. Harris P.A., Taylor R., Minor B.L., Elliott V., Fernandez M., O’Neal L., McLeod L., Delacqua G., Delacqua F., Kirby J., Duda S.N., REDCap Consortium The REDCap consortium: Building an international community of software platform partners. J. Biomed. Inform. 2019;95 doi: 10.1016/j.jbi.2019.103208.
    1. Harris P.A., Taylor R., Thielke R., Payne J., Gonzalez N., Conde J.G. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J. Biomed. Inform. 2009;42:377–381. doi: 10.1016/j.jbi.2008.08.010.
    1. Shinkins B., Thompson M., Mallett S., Perera R. Diagnostic accuracy studies: how to report and analyse inconclusive test results. BMJ. 2013;346:1–11. doi: 10.1136/bmj.f2778.

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