Overcoming the Blood-Brain Barrier with an Implantable Ultrasound Device

Abstract

Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.See related article by Idbaih et al., p. 3793.

Conflict of interest statement

The authors declare no relevant conflict of interest

©2019 American Association for Cancer Research.

Figures

Figure 1.

Next steps in development of implantable ultrasound. Boxes represent implantable ultrasound device.