Effect of Preemptive Flurbiprofen Axetil and Tramadol on Transurethral Resection of the Prostate under Spinal Anesthesia

Abstract

Objective. To investigate the efficacy of preoperative intravenous flurbiprofen axetil and tramadol on spinal anesthesia for transurethral resection of the prostate (TURP). Methodology. In this prospective clinical study, we enrolled 60 patients undergoing TURP under spinal anesthesia with small-dose bupivacaine and sufentanil. Patients were randomly divided in two: group flurbiprofen axetil and tramadol (Group FT) intravenously received 1 mg/kg flurbiprofen axetil and 1 mg/kg tramadol 20 min prior to the surgical procedures and group control (Group C) was given normal saline. The characteristics of spinal anesthesia, blood pressure, heart rate, analgesic requirement, visual analogue scale (VAS), and overall satisfaction degree were collected. Results. Time to the first analgesic requirement was significantly longer in Group FT. Patients who needed postoperative analgesics were fewer in Group FT. VAS scores were lower in Group FT at postoperative time points of 1, 2, 6, and 12 h. The patients in Group FT were more satisfied than in Group C. Conclusions. Preoperative flurbiprofen axetil and tramadol can reduce and delay postoperative pain and then decrease analgesic consumption for TURP under spinal anesthesia without an increase of side effects.

Figures

Figure 1

MBP at each time point (T1, basic mean blood pressure, 10 min after arriving at the operating room; T2, 5 min after spinal anesthesia; T3, 10 min after spinal anesthesia; T4, 5 min after drug administration; T5, 10 min after drug administration; T6, 30 min after drug administration; T7, 60 min after drug administration). MBP: mean blood pressure; Group FT: the flurbiprofen axetil and tramadol group; Group C: the control group.

Figure 2

HR at each time point (T1, basic heart rate, 10 min after arriving at the operating room; T2, 5 min after spinal anesthesia; T3, 10 min after spinal anesthesia; T4, 5 min after drug administration; T5, 10 min after drug administration; T6, 30 min after drug administration; T7, 60 min after drug administration). HR: heart rate; Group FT: the flurbiprofen axetil and tramadol group; Group C: the control group.

Figure 3

VAS scores at various time points postoperatively. Box plots of postoperative visual analogue scale scores. Results are expressed in median. The top and bottom of each box indicate 75th and 25th percentiles and the error bars minimum and maximum. ∗p < 0.05 between Group FT and Group C. VAS: visual analogue scale; Group FT: the flurbiprofen axetil and tramadol group; Group C: the control group.