Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial
J P Mohr, Michael K Parides, Christian Stapf, Ellen Moquete, Claudia S Moy, Jessica R Overbey, Rustam Al-Shahi Salman, Eric Vicaut, William L Young, Emmanuel Houdart, Charlotte Cordonnier, Marco A Stefani, Andreas Hartmann, Rüdiger von Kummer, Alessandra Biondi, Joachim Berkefeld, Catharina J M Klijn, Kirsty Harkness, Richard Libman, Xavier Barreau, Alan J Moskowitz, international ARUBA investigators, J P Mohr, Alan J Moskowitz, Ellen Moquete, Claudia S Moy, Michael K Parides, Rustam Al-Shahi Salman, Christian Stapf, Eric Vicaut, William L Young, J P Mohr, S Marshall, N Ostapkovich, K Lord, C Stapf, C Buchbinder, A J Moskowitz, M K Parides, E Moquete, K McDonald, A Estevez, S Varghese, J R Overbey, E Kumbarce, J Foo, E Vicaut, A Chamam, M Courrèges-Viaud, C Dert, U Fiedler, V Jouis, S Kabla, S Marchand, A Pena, V Rochaud, Karen Furie, Barry R Davis, Michael D Hill, Charles Jungreis, Renee Martin, Duke Samson, Peter R Gilbert, Anthony Furlan, C S Moy, L S Janis, P R Gilbert, Marie-Germaine Bousser, Louis R Caplan, Charles Strother, Brice A K Weir, Hans-Martin Schneble, Aman Patel, Phil M Meyers, John Pile-Spellman, E Houdart, D Bresson, B George, J P Saint-Maurice, C Stapf, J P Lejeune, P Aguettaz, S Blond, C Cordonnier, X Leclerc, C Rossi, A Biondi, R Billon-Grand, T Moulin, X Barreau, C Marchal, V Michel, A Thévenoux, I Tedeschi, S Timsit, P Dam-Hieu, P Meriot, F M Merrien, A S Nedelec, M Nonent, F Nataf, D Calvet, E Touzé, D Trystram, R von Kummer, M Baumann, U Bodechtel, I Dzialowski, H Hentschel, J Kepplinger, V Pütz, G Schackert, K Wartenberg, A Hartmann, T Funk, A Schilling, R Wurm, J Berkefeld, H Braun, M W Lorenz, I Santos, V Seifert, R Wolff, J Meisel, E Herrmann, C Hohaus, Y Minkus, M Dichgans, H Brueckmann, A Dörr, G Fesl, A Muacevic, C Schichor, F Wollenweber, B M Wowra, A Zollver, M Schumacher, U Bergmann, C Hader, W D Niesen, C Taschner, V Velthoven-Wurster, I Wanke, S Hagedorn, O Kastrup, I Sandalcioglu, U Sure, H B van der Worp, C J M Klijn, J W Berkelbach van der Sprenkel, T H Lo, J M C van Dijk, O Eshghi, G J Luijckx, M Arnold, A Raabe, G Schroth, M Heldner, M Reinert, R Al-Shahi Salman, B Colam, S Erridge, R Sellar, J Steers, P M White, K Harkness, S Coley, T Hodgeson, E Richards, U Patel, A D Mendelow, A Gholkar, P Mitchell, B Gregson, H Nahser, M Javadpour, P Enevoldson, R White, J Molloy, D Hughes, C Sherrington, M A Stefani, M L Fagundes Chaves, A Finkelsztejn, D Roy, J Raymond, F Guilbert, T Darsaut, K Butcher, J Silva, P Klurfan, Byung-Woo Yoon, J A Kim, S Jung, Y Kim, C Kim, R Libman, D J Langer, J P Mohr, T Kitago, W L Young, M T Lawton, R Higashida, S C Johnston, L Feng, J Chen, Z Ajani, S Potrebic, E Wirkowski, J Pile-Spellman, M Brisman, J Jasen, I Kureshi, G Spiegel, I Silverman, S Koch, R L Sacco, M Chen, V Lee, S Prabhakaran, M Harrigan, J Brockington, R M Zweilfer, J I Lopez, J Biller, M Schneck, D Anderson, S Cullen, V Rao, N Moayeri, V Tse, A P Bowles Jr, K Nassr, J P Mohr, Michael K Parides, Christian Stapf, Ellen Moquete, Claudia S Moy, Jessica R Overbey, Rustam Al-Shahi Salman, Eric Vicaut, William L Young, Emmanuel Houdart, Charlotte Cordonnier, Marco A Stefani, Andreas Hartmann, Rüdiger von Kummer, Alessandra Biondi, Joachim Berkefeld, Catharina J M Klijn, Kirsty Harkness, Richard Libman, Xavier Barreau, Alan J Moskowitz, international ARUBA investigators, J P Mohr, Alan J Moskowitz, Ellen Moquete, Claudia S Moy, Michael K Parides, Rustam Al-Shahi Salman, Christian Stapf, Eric Vicaut, William L Young, J P Mohr, S Marshall, N Ostapkovich, K Lord, C Stapf, C Buchbinder, A J Moskowitz, M K Parides, E Moquete, K McDonald, A Estevez, S Varghese, J R Overbey, E Kumbarce, J Foo, E Vicaut, A Chamam, M Courrèges-Viaud, C Dert, U Fiedler, V Jouis, S Kabla, S Marchand, A Pena, V Rochaud, Karen Furie, Barry R Davis, Michael D Hill, Charles Jungreis, Renee Martin, Duke Samson, Peter R Gilbert, Anthony Furlan, C S Moy, L S Janis, P R Gilbert, Marie-Germaine Bousser, Louis R Caplan, Charles Strother, Brice A K Weir, Hans-Martin Schneble, Aman Patel, Phil M Meyers, John Pile-Spellman, E Houdart, D Bresson, B George, J P Saint-Maurice, C Stapf, J P Lejeune, P Aguettaz, S Blond, C Cordonnier, X Leclerc, C Rossi, A Biondi, R Billon-Grand, T Moulin, X Barreau, C Marchal, V Michel, A Thévenoux, I Tedeschi, S Timsit, P Dam-Hieu, P Meriot, F M Merrien, A S Nedelec, M Nonent, F Nataf, D Calvet, E Touzé, D Trystram, R von Kummer, M Baumann, U Bodechtel, I Dzialowski, H Hentschel, J Kepplinger, V Pütz, G Schackert, K Wartenberg, A Hartmann, T Funk, A Schilling, R Wurm, J Berkefeld, H Braun, M W Lorenz, I Santos, V Seifert, R Wolff, J Meisel, E Herrmann, C Hohaus, Y Minkus, M Dichgans, H Brueckmann, A Dörr, G Fesl, A Muacevic, C Schichor, F Wollenweber, B M Wowra, A Zollver, M Schumacher, U Bergmann, C Hader, W D Niesen, C Taschner, V Velthoven-Wurster, I Wanke, S Hagedorn, O Kastrup, I Sandalcioglu, U Sure, H B van der Worp, C J M Klijn, J W Berkelbach van der Sprenkel, T H Lo, J M C van Dijk, O Eshghi, G J Luijckx, M Arnold, A Raabe, G Schroth, M Heldner, M Reinert, R Al-Shahi Salman, B Colam, S Erridge, R Sellar, J Steers, P M White, K Harkness, S Coley, T Hodgeson, E Richards, U Patel, A D Mendelow, A Gholkar, P Mitchell, B Gregson, H Nahser, M Javadpour, P Enevoldson, R White, J Molloy, D Hughes, C Sherrington, M A Stefani, M L Fagundes Chaves, A Finkelsztejn, D Roy, J Raymond, F Guilbert, T Darsaut, K Butcher, J Silva, P Klurfan, Byung-Woo Yoon, J A Kim, S Jung, Y Kim, C Kim, R Libman, D J Langer, J P Mohr, T Kitago, W L Young, M T Lawton, R Higashida, S C Johnston, L Feng, J Chen, Z Ajani, S Potrebic, E Wirkowski, J Pile-Spellman, M Brisman, J Jasen, I Kureshi, G Spiegel, I Silverman, S Koch, R L Sacco, M Chen, V Lee, S Prabhakaran, M Harrigan, J Brockington, R M Zweilfer, J I Lopez, J Biller, M Schneck, D Anderson, S Cullen, V Rao, N Moayeri, V Tse, A P Bowles Jr, K Nassr
Abstract
Background: The clinical benefit of preventive eradication of unruptured brain arteriovenous malformations remains uncertain. A Randomised trial of Unruptured Brain Arteriovenous malformations (ARUBA) aims to compare the risk of death and symptomatic stroke in patients with an unruptured brain arteriovenous malformation who are allocated to either medical management alone or medical management with interventional therapy.
Methods: Adult patients (≥18 years) with an unruptured brain arteriovenous malformation were enrolled into this trial at 39 clinical sites in nine countries. Patients were randomised (by web-based system, in a 1:1 ratio, with random permuted block design [block size 2, 4, or 6], stratified by clinical site) to medical management with interventional therapy (ie, neurosurgery, embolisation, or stereotactic radiotherapy, alone or in combination) or medical management alone (ie, pharmacological therapy for neurological symptoms as needed). Patients, clinicians, and investigators are aware of treatment assignment. The primary outcome is time to the composite endpoint of death or symptomatic stroke; the primary analysis is by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00389181.
Findings: Randomisation was started on April 4, 2007, and was stopped on April 15, 2013, when a data and safety monitoring board appointed by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health recommended halting randomisation because of superiority of the medical management group (log-rank Z statistic of 4·10, exceeding the prespecified stopping boundary value of 2·87). At this point, outcome data were available for 223 patients (mean follow-up 33·3 months [SD 19·7]), 114 assigned to interventional therapy and 109 to medical management. The primary endpoint had been reached by 11 (10·1%) patients in the medical management group compared with 35 (30·7%) in the interventional therapy group. The risk of death or stroke was significantly lower in the medical management group than in the interventional therapy group (hazard ratio 0·27, 95% CI 0·14-0·54). No harms were identified, other than a higher number of strokes (45 vs 12, p<0·0001) and neurological deficits unrelated to stroke (14 vs 1, p=0·0008) in patients allocated to interventional therapy compared with medical management.
Interpretation: The ARUBA trial showed that medical management alone is superior to medical management with interventional therapy for the prevention of death or stroke in patients with unruptured brain arteriovenous malformations followed up for 33 months. The trial is continuing its observational phase to establish whether the disparities will persist over an additional 5 years of follow-up.
Funding: National Institutes of Health, National Institute of Neurological Disorders and Stroke.
Conflict of interest statement
Conflicts of interest
We declare that we have no conflicts of interest.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Figures
Source: PubMed