The efficacy of combined herbal extracts gel preparation in the prevention of postsurgical hypertrophic scar formation

Apirag Chuangsuwanich, Krit Jongjamfa, Apirag Chuangsuwanich, Krit Jongjamfa

Abstract

Introduction: The objective of preventing surgical scar formation is to improve the quality of life for patients. Many medical products have been used in preventing hypertrophic scarring but an optimal treatment method has not been established yet. At the present, there are several studies demonstrating the potential of herbs in scar prevention. The purpose of this study was to evaluate the efficacy of combined herbal extracts gel (CHG) in the prevention of surgical scar formation.

Methods: All the patients who underwent bilaterally symmetric surgical procedures were selected using inclusion and exclusion criteria and were then treated with both the CHG (CHG group) and placebo gel. Each gel was applied on separate scars twice daily for 12 weeks. The scars were photographed and evaluated using Patient and Observer Scar Assessment Scale (PSAS and OSAS, respectively).

Results: The CHG-treated scars showed lower median PSAS scores than the placebo group in color, stiffness, thickness, irregularity, and overall scores, with statistically significant difference at 12 weeks. For OSAS, the scars in the CHG group showed lower median scores than the placebo group in pigmentation, thickness, and overall scores at 12 weeks. The median OSAS scores in vascularity, relief, and pliability differed from placebo group and were statistically significant at 8 weeks. No side effects were observed in either group.

Conclusion: The CHG might be effective in the prevention of surgical scarring.

Figures

Fig. 1
Fig. 1
Patient Scar Assessment Scale score comparison between combined herbal extracts gel (CHG) and placebo group at 2, 4, 8, and 12 weeks’ follow-up
Fig. 2
Fig. 2
Observer Scar Assessment Scale score comparison between combined herbal extracts gel (CHG) and placebo group at 2, 4, 8, and 12 weeks’ follow-up
Fig. 3
Fig. 3
A 30-year-old female patient underwent excision nevus at both arms. At 8 weeks’ follow-up, PSAS for CHG and placebo groups were 15 and 21, respectively, and OSAS for CHG and placebo groups were 14 and 23, respectively. At 12 weeks’ follow-up, PSAS for CHG and placebo groups were 12 and 19, respectively, and OSAS for CHG and placebo groups were 12 and 21, respectively. CHG combined herbal extracts gel, OSAS Observer Scar Assessment Scale, PSAS Patient Scar Assessment Scale
Fig. 4
Fig. 4
A 40-year-old female patient underwent bilateral breast reduction. At 4 weeks’ follow-up, PSAS scores for the CHG and placebo groups were 29 and 32, respectively, and OSAS scores for the CHG and placebo groups were 21 and 28, respectively. At 12 weeks’ follow-up, PSAS scores for the CHG and placebo groups were 21 and 21, respectively, and OSAS scores for the CHG and placebo groups were 21 and 22, respectively. CHG combined herbal extracts gel, OSAS Observer Scar Assessment Scale, PSAS Patient Scar Assessment Scale

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