Dynamical systems approach to endothelial heterogeneity
Erzsébet Ravasz Regan, William C Aird, Erzsébet Ravasz Regan, William C Aird
Abstract
Endothelial cells display remarkable phenotypic heterogeneity. An important goal is to elucidate the scope and mechanisms of endothelial heterogeneity and to use this information to develop vascular bed-specific therapies. We reexamine our current understanding of the molecular basis of endothelial heterogeneity. We introduce multistability as a new explanatory framework in vascular biology. We draw on the field of nonlinear dynamics to propose a dynamical systems framework for modeling multistability and its derivative properties, including robustness, memory, and plasticity. Our perspective allows for both a conceptual and quantitative description of system-level features of endothelial regulation.
Figures
![Figure 1. Examples of endothelial heterogeneity](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0001.jpg)
![Figure 2. Conceptual frameworks for understanding endothelial…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0002.jpg)
![Figure 3. Dynamical systems perspective of endothelial…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0003.jpg)
![Figure 4. Linear and crosstalking GATA-2 signaling…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0004.jpg)
![Figure 5. Agonist-mediated signaling pathways with crosstalk](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0005.jpg)
![Figure 6. Bistability due to positive feedback](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0006.jpg)
![Figure 7. Boolean model of a caspase-mediated…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0007.jpg)
![Figure 8. A dynamical systems view of…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3400545/bin/nihms-386323-f0008.jpg)
Source: PubMed