Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study
Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, Olivier Godefroy, Trevor Shields, Audrey Perrotin, Rossella Gismondi, Santiago Bullich, Aleksandar Jovalekic, Nicola Raffa, Florence Pasquier, Franck Semah, Bruno Dubois, Marie-Odile Habert, David Wallon, Mathieu Chastan, Pierre Payoux, NEUUS in AD study group, Andrew Stephens, Eric Guedj, Mathieu Ceccaldi, Eric Guedj, Mathieu Ceccaldi, Olivier Felician, Mira Didic, Claude Gueriot, Lejla Koric, Radka Kletchkova-Gantchev, Eric Guedj, Olivier Godefroy, Daniela Andriuta, Agnès Devendeville, Diane Dupuis, Ingrid Binot, Mélanie Barbay, Marc-Etienne Meyer, Véronique Moullard, Eloi Magnin, Ludivine Chamard, Sophie Haffen, Olivier Morel, Clément Drouet, Hatem Boulahdour, Philippe Goas, Solène Querellou-Lefranc, Vincent de la Sayette, Julien Cogez, Pierre Branger, Denis Agostini, Alain Manrique, Olivier Rouaud, Yannick Bejot, Agnès Jacquin-Piques, Inna Dygai-Cochet, Alina Berriolo-Riedinger, Olivier Moreaud, Mathilde Sauvee, Céline Gallazzani Crépin, Florence Pasquier, Stéphanie Bombois, Thibaud Lebouvier, Marie-Anne Mackowiak-Cordoliani, Vincent Deramecourt, Adeline Rollin-Sillaire, Pascaline Cassagnaud-Thuillet, Yaohua Chen, Franck Semah, Grégory Petyt, Pierre Krolak-Salmon, Denis Federico, Keren Liora Danaila, Yves Guilhermet, Christophe Magnier, Zaza Makaroff, Isabelle Rouch, Jing Xie, Caroline Roubaud, Marie-Hélène Coste, Kenny David, Alain Sarciron, Aziza Sediq Waissi, Christian Scheiber, Claire Houzard, Audrey Gabelle-Deloustal, Karim Bennys, Cecilia Marelli, Lynda Touati, Denis Mariano-Goulart, Delphine de Verbizier-Lonjon, Thérèse Jonveaux, Athanase Benetos, Anna Kearney-Schwartz, Christine Perret-Guillaume, Antoine Verger, Martine Vercelletto, Claire Boutoleau-Bretonniere, Hélène Pouclet-Courtemanche, Nathalie Wagemann, Amandine Pallardy, Jacques Hugon, Claire Paquet, Julien Dumurgier, Pascal Millet, Mathieu Queneau, Bruno Dubois, Stéphane Epelbaum, Marcel Levy, Marie-Odile Habert, Jean-Luc Novella, Yacine Jaidi, Dimitri Papathanassiou, David Morland, Serge Belliard, Anne Salmon, Florence Lejeune, Didier Hannequin, David Wallon, Olivier Martinaud, Aline Zarea, Mathieu Chastan, Jérémie Pariente, Claire Thalamas, Monique Galitzky-Gerber, Anne-Marie Tricoire Ricard, Fabienne Calvas, Emilie Rigal, Pierre Payoux, Anne Hitzel, Julien Delrieu, Pierre-Jean Ousset, Françoise Lala, Nathalie Sastre-Hengan, Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, Olivier Godefroy, Trevor Shields, Audrey Perrotin, Rossella Gismondi, Santiago Bullich, Aleksandar Jovalekic, Nicola Raffa, Florence Pasquier, Franck Semah, Bruno Dubois, Marie-Odile Habert, David Wallon, Mathieu Chastan, Pierre Payoux, NEUUS in AD study group, Andrew Stephens, Eric Guedj, Mathieu Ceccaldi, Eric Guedj, Mathieu Ceccaldi, Olivier Felician, Mira Didic, Claude Gueriot, Lejla Koric, Radka Kletchkova-Gantchev, Eric Guedj, Olivier Godefroy, Daniela Andriuta, Agnès Devendeville, Diane Dupuis, Ingrid Binot, Mélanie Barbay, Marc-Etienne Meyer, Véronique Moullard, Eloi Magnin, Ludivine Chamard, Sophie Haffen, Olivier Morel, Clément Drouet, Hatem Boulahdour, Philippe Goas, Solène Querellou-Lefranc, Vincent de la Sayette, Julien Cogez, Pierre Branger, Denis Agostini, Alain Manrique, Olivier Rouaud, Yannick Bejot, Agnès Jacquin-Piques, Inna Dygai-Cochet, Alina Berriolo-Riedinger, Olivier Moreaud, Mathilde Sauvee, Céline Gallazzani Crépin, Florence Pasquier, Stéphanie Bombois, Thibaud Lebouvier, Marie-Anne Mackowiak-Cordoliani, Vincent Deramecourt, Adeline Rollin-Sillaire, Pascaline Cassagnaud-Thuillet, Yaohua Chen, Franck Semah, Grégory Petyt, Pierre Krolak-Salmon, Denis Federico, Keren Liora Danaila, Yves Guilhermet, Christophe Magnier, Zaza Makaroff, Isabelle Rouch, Jing Xie, Caroline Roubaud, Marie-Hélène Coste, Kenny David, Alain Sarciron, Aziza Sediq Waissi, Christian Scheiber, Claire Houzard, Audrey Gabelle-Deloustal, Karim Bennys, Cecilia Marelli, Lynda Touati, Denis Mariano-Goulart, Delphine de Verbizier-Lonjon, Thérèse Jonveaux, Athanase Benetos, Anna Kearney-Schwartz, Christine Perret-Guillaume, Antoine Verger, Martine Vercelletto, Claire Boutoleau-Bretonniere, Hélène Pouclet-Courtemanche, Nathalie Wagemann, Amandine Pallardy, Jacques Hugon, Claire Paquet, Julien Dumurgier, Pascal Millet, Mathieu Queneau, Bruno Dubois, Stéphane Epelbaum, Marcel Levy, Marie-Odile Habert, Jean-Luc Novella, Yacine Jaidi, Dimitri Papathanassiou, David Morland, Serge Belliard, Anne Salmon, Florence Lejeune, Didier Hannequin, David Wallon, Olivier Martinaud, Aline Zarea, Mathieu Chastan, Jérémie Pariente, Claire Thalamas, Monique Galitzky-Gerber, Anne-Marie Tricoire Ricard, Fabienne Calvas, Emilie Rigal, Pierre Payoux, Anne Hitzel, Julien Delrieu, Pierre-Jean Ousset, Françoise Lala, Nathalie Sastre-Hengan
Abstract
Introduction: Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting.
Methods: This multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172).
Results: Two hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases.
Discussion: High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases.
Keywords: Alzheimer's disease; Amyloid imaging; Clinical practice; Diagnosis; Florbetaben; Patient management.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Source: PubMed